Basic Information

Gene Symbol
MBD-R2_1
Assembly
GCA_949825045.1
Location
OX463809.1:36966374-36998390[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 3.1e-08 0.001 21.4 0.1 5 34 814 843 810 849 0.89
2 3 0.37 1.2e+04 -1.3 0.0 37 54 1014 1031 1012 1047 0.82
3 3 2.3e-11 7.7e-07 31.4 0.0 6 55 1107 1156 1102 1184 0.87

Sequence Information

Coding Sequence
ATGGCGATTAAAAACTGTTGTATTGAGGACTGTTTCTCATGCTCGACAAAAGAAGAAGATGTGGGTGTGACATACCATAAGTTTCCAAAAGACACGACACTTCGAGATATCTGGACTAAAATAACACAGTTTATTGATAAGGATGTAAAATTGCCTTATGTTTGCTCGCGGCATTTCTGTAAAAGTGATTTTCAATCATTAAAGGATTCTAAATATGTGTTAAAGTCAGATGCTGTGCCATCAATTTTTCCCTGGACAATAAGGGACATTTCTGACATAAATATGGAGtcaaatgaaaaagaaaaagatgcttcaaaagaaaataatactgAACCAATGCAAGCAGAAGcaaataaaccaaaaacagtgCAACCGGATGAACCAAAACTTGATGATGTTGAGAATGCTTCAGTTGGCCTTGACACCAGCAAAGAATCTGAAGGAGAAGGCATTGAAGCCATCAGAAAGTTTATTGAGGAACAGGAAAAAGAAATACAAGAGTTACAAGCAGAAGTAAAACCACTCACACCTAGAATTGTTTCCGAAACTTATAGTAAGAAAGATGAAGAAATTAAAACTGAAAAACAGGATTCAAAAGATGAAGCAAAAGGCAGTGAAGTTGCAATCAGTGATAATAATGTCTTGGATGATTTAAGCAATGATGCTATAATCGAAGATGATAAAAGCGATAATGTAAAGAGTAAAGAAGATAGAAGTGATGATACTGAGCGTCATGaatatgtcaaaattacaaTAGAGGACAAAAGCAATGATAATAAAACCAGAGGTGGTACAAGCAATGCCAAAAAAACACAAATGAAAGACAAGAAACCTAAAAAAGATCTTGTACTAGAAGAGCAACATGATGAAAATATGTCTATGACAGTAGCCTCAGATGTGATGAACATAATACTAAGTGAATCAGAAGCTAAATTGGCTAAGCCAACAGATGGTGTAAAGACACCCAAACAGAATTTATTGTCTGGAGAAAAAGGCAGCAGTTCGATGGCGTTGTCTGTCGGCTCCAAGATCGAGGCGAAAGACTACGGAGAACACTGGCACTCGGCTAACATTGCTGAGGTGGATTATGACGAAATGGAAGTGCTTGTGCGATATGAGAATCTTTCTAAAAAACACGACGAATGGATAAGTGTAAGCAGCCCGCGGCTGCGTCCGCAGGGCAGCCCAGCCAAGGCACAAGCCGAGCTTAATCCAGAGCCAGTCGTCAAAGAAGATCCGAGGGAGGAGAAACCAAAGATGCCGTACAAAGTTGGAGACAGGTGCTTGGCGAGGTGGCGGGACAATAGGCGGTTCCAGGCCACTGTGCTTGCTGATTTCGGGGATGGCAACTACGAAGTCGTATTCGACGACGGCTTCGTCTGGCGCTGCCCGGTCGTGCGGCTCTCCAAGATGAGGGTCGGAGACAGAAAGTCTTCCCTCTCTATCCCTCTCCGGGTGAACACCGCCCTGCCCCCCGCCCCTTCCCCGCTCCCCACCCCTCCCGGGTCCACCGCCGAGCCCCCCTATCACACACACCTCTTTGACCCCGCCCGCGACTTCTTAGGTTCGAAAAGCGACCGCCGCGAGAGAAAGAGAAAGCTGAACATAAAAGAGATATTCAACATTGggcagaagaagaagaaagatgAATCCGCTTCGGCGAAGAAGGTTAAGACGGAGCCCGCGGAAAAGAAACCGAAAGTGGTTAAACAGAAAGCCGAAAGCGCGAAGGGGATACACATCAAGACTGAAGTGAAACCGGTGCTGCCTGATGCCGTGGCATGTATTATCGGCTCAGTAGCTGAGGATGTACCGATAAAGACTGAAATAAAAGAAGTGGTGATTAAACAGGAAGAACCTCAGGAGGCAACTGATGTTGAGGAAGACAAGATGCAAGTGGATGAGGTGGTCATGATCGATCCTTCACTTCCTGTTGATACTGagGTTCAAGAAGAAGAACCTAAAGATGACACTAATGCTGACTCAATCACTATAAAAAATGATGAAGAAATGCTCAAGATACTTGAAGCCTACAACAAAATAGAAGACAAATTTAGCAAACCCGTCAGCCCCATACCTGCCATCAGCAACATGAAGCCCGAACCAAAGCcccaagaaaaagaaaaatctaAACCACCGAAGGCCAAAAAGaccaaaaaattaaaacaactcCGAGATACAAAAGTCAACGAAGAGGTCCTAAAGGTCAAAATTGAACTGGAAGCCGTTAAAAGCCAGTTGGCAGCTATAAAGAAGCGAGCAGGTCTCAACCAGGATGAATGGCTGAAGGACCAGGCCGGTGGTCATCCAATACCAATGCCGGACAGTTACCTGCTGCCGGGCATGTGGTGTTGCAAGTGGCATAATGGTGAACCGGTCGGCATAAGTGAGATGGAGTTTGATTCAAAGGACGCTAAGGGGCTGCCACGGCGGTCTGTTCAGGTAGAGGACAAGCGTCTGCCCTCTGGCTGGACGAAGCACATGGTGCGCCGCAGTCTCGGCACCTCGGCTGGCAAGTGGGACGTCGTGATAGTCGCGGTTCCCTCATCGGAGGACCGTAGCCGTTCACTCACCGCGAAAGTGAAGGAAAATGTTGCTAATGAAGCTCCGAGGGACTCACTTTCATCAGTTTGCGCCGCGAGGGGGGTTTCCTTGGGTCAGAGGTCGTTTTATAGATTAGCAGAATCGAAGGTGTACGATGGTGATCTGAGTGGAGCGGTTCGGGTATTATTGTCGGACTGTTCCATTGCACCTGATAATGACGAGACCTTGAAAGCTTTGAGAGAAAAGCATCCTTCTCCTAACCGACCTTTGGACTTTCCTCCTGAGCCTGATCTTTCTTTGGAGTGCATATCTGTGGAGTGGGGTGACGTTGTGCAGACAATTGCCTCTTTTAAGAACGGCTTGGCGGGTGGGTTGAATGGTTTGCGCCCTGAGCACCTTAAGGAGTTAACTTCTGTAGGGGCTGGTGATGGTGGGGTTGCACTGTTGAGTTCTCTATGTAACTTGACAAACTACATGTTGAAGGGCGTGATTAATAGCCCGGACAACAAACGCCTACACACCAAAACAGACATGCAACACTACCTCGACGGAATAAGACACGACGACTATCGCGCGTCCCTAGAGCCCTTCGAACATGTCCTGCTAGATTTCGGCGTCCACCGCAAGATGGCGCGCCGCCTCGGCTGGGATACGAAAACTGTGGGGCCAGACGGAGATGTGAGGCCGCCGCCGCTTATTAGTACGACGTCTCCGCTGGTGAAGTTGACGAAGATGAACGTTCGGAAGGAGAAAGCTAAAATGGCGGTTTCGAAGAGGAGGAAGATGAGCCTGCCCACTGGCTGGACGAAGCACATGGTGCGCCGCAGTCTCGGCAAATCGGCTGGCAAGTGGGGCGTCATGATAGTCGCCCCGGACAACAAACGCCTACACACCAAAACAGACATGCGACACTACCTCGACGGAATAAGACACAAAGAATATCGCGCGTCCCTAGAGCCCTTCGAAGATGTCCTGCTAGATTTCGGCGTCCACCGCAAGATGGCGCGCCGCCTCGGCTGGGATACGAAAACTGTGGGGCCAGACGGAGATGTGAGGCCGCCGCCACTTATTAGTACGACGTCTCCACTGGTGAAGTTAACGAAGATGAACGTTCGGAAGGAGAAAGCTAAACTGGCGCATGCGAAGAGGAGGAAGATTAGCTCAGGAGGGTACTCTAACTCGTCATCCGTGACGTCATCGCCAGCGGATCAGGCGGTAGCTGGCGCTGTGACGCCCAGCGACACATGCTTCGAACACCCGCCGTTGGAAGACGGATACGTGTATGTTGGTTCGTTAAAAGTACAAATTATCGAGAATCTCCTCCGGTGCCCGGCCGACGCCTGCTTCAAAAACTTCCGGACACCCACACTGCTGCAAATGCACATAAAGCACTACCATAGAGAAATGCGAAAAATGATGGGCGCTACTCCCAAAGTGGCCGACCTAGCCTCAGCCAGGGCCACGCCGCTGATGCCGGACAAGATCAAGACAGAAAGCGAACCTAAAGTCCCCAAACTGAAAATAAGCAAGAAACGCGTCGAGGAAATAAAGATCGAGCCCGTAGAACCCAAGTACGAGATGAAAACGGAAACAACACCAATGACAACACCTACCAGAACCGACCCGGACAAGATACCCCGGTCCCTAGACTCCCCAAGACTCAGAAACGCGCTCGTATTCAGCTCTAAGCCTCACAAGCGGCCAAGAGTTCTCCTGCCAGTCAGAAAATCAGAAGAACCACAGGACGACGCAGATTCCTCAGACTCCACTGACTCCGAAATTAACGTATCATCCAACGTGGAGCAATTAACTGTACTGGACTTCGAATCAGCCATATCCACCCACACAGTCACAAAACCAGTTGTGTCTGAAAAAAAGAAGAAGGGAGAGAAACGCAAGAAGACCTTCGCCACGATATCCAAGGTGAAGCCAGGCAGTGATGATGAAGaatgggacgccaattccgacTACGAGACTAGATCTAGTTTCCCGCGGTCGGGTAGTCCTGACTCCAAGTTTATGGACACTTCTACCATGCCGGTGTCGTCGGAGTCCACTGAGGATCAGAAGGATCCAAATATGTACATGTTTACTGAGACCGGCGAGCGTATAAAGCTGGTGCATATGAAACGCGAAGAAATCATCAATTGTCACTGCACGGTCCGTGAAGAGGACGGTCTTATGATACAGTGCGAGCTGTGTCTGTGTTGGCAGCACGCGCTGTGTCACAACATACACAAGGAGGCTGAGGTCCCAGAAAAGTACACGTGCTCGATCTGCCTCAACCCGCGCCTGGGCCGTCGCTCGCGCCGCTTCCTGCACGACCAGGACCGCCTGTACGAGGGGCTGCTGCCCGGCGCGCGCGCCTGCCCCTCGCTGCGGCGCGCGCACGAGCTGTCGGGCAATCTGCTGGGCATACAGGACGCGCTGCATGCGCTGCGTGTGAAGAACTATGTCGCCACGTGA
Protein Sequence
MAIKNCCIEDCFSCSTKEEDVGVTYHKFPKDTTLRDIWTKITQFIDKDVKLPYVCSRHFCKSDFQSLKDSKYVLKSDAVPSIFPWTIRDISDINMESNEKEKDASKENNTEPMQAEANKPKTVQPDEPKLDDVENASVGLDTSKESEGEGIEAIRKFIEEQEKEIQELQAEVKPLTPRIVSETYSKKDEEIKTEKQDSKDEAKGSEVAISDNNVLDDLSNDAIIEDDKSDNVKSKEDRSDDTERHEYVKITIEDKSNDNKTRGGTSNAKKTQMKDKKPKKDLVLEEQHDENMSMTVASDVMNIILSESEAKLAKPTDGVKTPKQNLLSGEKGSSSMALSVGSKIEAKDYGEHWHSANIAEVDYDEMEVLVRYENLSKKHDEWISVSSPRLRPQGSPAKAQAELNPEPVVKEDPREEKPKMPYKVGDRCLARWRDNRRFQATVLADFGDGNYEVVFDDGFVWRCPVVRLSKMRVGDRKSSLSIPLRVNTALPPAPSPLPTPPGSTAEPPYHTHLFDPARDFLGSKSDRRERKRKLNIKEIFNIGQKKKKDESASAKKVKTEPAEKKPKVVKQKAESAKGIHIKTEVKPVLPDAVACIIGSVAEDVPIKTEIKEVVIKQEEPQEATDVEEDKMQVDEVVMIDPSLPVDTEVQEEEPKDDTNADSITIKNDEEMLKILEAYNKIEDKFSKPVSPIPAISNMKPEPKPQEKEKSKPPKAKKTKKLKQLRDTKVNEEVLKVKIELEAVKSQLAAIKKRAGLNQDEWLKDQAGGHPIPMPDSYLLPGMWCCKWHNGEPVGISEMEFDSKDAKGLPRRSVQVEDKRLPSGWTKHMVRRSLGTSAGKWDVVIVAVPSSEDRSRSLTAKVKENVANEAPRDSLSSVCAARGVSLGQRSFYRLAESKVYDGDLSGAVRVLLSDCSIAPDNDETLKALREKHPSPNRPLDFPPEPDLSLECISVEWGDVVQTIASFKNGLAGGLNGLRPEHLKELTSVGAGDGGVALLSSLCNLTNYMLKGVINSPDNKRLHTKTDMQHYLDGIRHDDYRASLEPFEHVLLDFGVHRKMARRLGWDTKTVGPDGDVRPPPLISTTSPLVKLTKMNVRKEKAKMAVSKRRKMSLPTGWTKHMVRRSLGKSAGKWGVMIVAPDNKRLHTKTDMRHYLDGIRHKEYRASLEPFEDVLLDFGVHRKMARRLGWDTKTVGPDGDVRPPPLISTTSPLVKLTKMNVRKEKAKLAHAKRRKISSGGYSNSSSVTSSPADQAVAGAVTPSDTCFEHPPLEDGYVYVGSLKVQIIENLLRCPADACFKNFRTPTLLQMHIKHYHREMRKMMGATPKVADLASARATPLMPDKIKTESEPKVPKLKISKKRVEEIKIEPVEPKYEMKTETTPMTTPTRTDPDKIPRSLDSPRLRNALVFSSKPHKRPRVLLPVRKSEEPQDDADSSDSTDSEINVSSNVEQLTVLDFESAISTHTVTKPVVSEKKKKGEKRKKTFATISKVKPGSDDEEWDANSDYETRSSFPRSGSPDSKFMDTSTMPVSSESTEDQKDPNMYMFTETGERIKLVHMKREEIINCHCTVREEDGLMIQCELCLCWQHALCHNIHKEAEVPEKYTCSICLNPRLGRRSRRFLHDQDRLYEGLLPGARACPSLRRAHELSGNLLGIQDALHALRVKNYVAT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00162936;
90% Identity
iTF_00162936;
80% Identity
iTF_00162936;