Basic Information

Gene Symbol
IBTK
Assembly
GCA_033884665.1
Location
CM066623.1:4525598-4540307[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 7.7e-18 3.1e-15 56.9 0.0 5 80 550 623 546 629 0.92
2 3 1.1e-10 4.5e-08 33.9 0.1 9 107 739 841 735 844 0.81
3 3 3.7 1.5e+03 0.0 0.1 79 107 845 873 841 876 0.87

Sequence Information

Coding Sequence
ATGAATAAGACTATTGAAGTAGATTGTACTAGACGTTGTAAGTCAAGGATTCATGGGCAGGTTTTGACTAGTGCCATAACCAAGAGATCTATTAGTGATGAATCTCTCGCCAGTTTTATTAAATCAACTTGTGCTAATTTTGCCAAGGCATTTGATTTTGAGGGTCGAACTGCTTTGCATATGACTGCATCTAGAGGCAGAAATGATTTAATGGAATGGCTTGTACGTCATTCCTCTGACGCATTCATAAATGCTCGCGATCGAGAATCGGGTTATACTCCATTGCATAGAAGTATTTTCTATGGGCAAATACATTCTGCAGTTACTCTTATGAAACttgGTGTCAACACGGACATCCAAGATAAAGATGACTATAAAGCAATAGAGCATGCGATGCTCGATAAGCATTatatgtacaaacaaacaggcTCAGAGCCCTGCGACGCGTATGTATGGGGAAGTAACACGAACTATACGTTGGGTACGGGATCCCAACAGCCGAAGAACATTCCTGATCTGCTTGGTTGCTTCAGCCGTGCGAATGCTAATCTTAGACAGGTATGTCTCGGTAAATTCCATAGCGTATGGGTTTGTGGTTCTAACGATAATGGGGAAGTGTGGTGTGCCGGCCAACCGGCTCGTGCGGGCGGTCCTCATACCACCGCCCTTCGTCCAACACCGCTTAAACTACCTGAGCCATGTCTGCAAGTTGCTATCACATTGACGTCGACTGTCTTCTTACTACAAAGTGGAGCGGTGATCCAATACACATTAAACAACACGGAGAATCCAAGTCCCTCATCAGTTAAGAGCCCTTCGACAATAAAGCTGGCATCAGTCAAACCGCTTATAAAATTATCCCAACCGTTGGGCGTTAGTGCGGGACGCTCCCACGCTGTAGTCTGGAACAAGAACGCGGTGTACACCTGGGGACTAAACTTGGGCCAGTTGGGACATCCTCAGGAGGAGAAAGTTATTCAAGCTCCGAAAAGGGTTGGTATATCTCTAAACAACAAAGAAGAATCCAGCCTCCAACTAGTGGACGCGACGGACGCCGCCACCGTCATAACGACCAGTCGCGGGGATGTGTACCTTCTGCATAGATATCTGTGCAAAAAGATTGCTGTTAAGCAAATCAATCTTAAACAAGTGTGTGTAGAGGCAAAGGTAAATGAACAAGGGTCATATTCGAGAGTAACTGTCTTACTACTGACCAACGTTGGTCAACTCATGCTTTGGCAAGACACTACAAACAAACTGACtagATGCGTCTTCGGCTTAAATCACCAAACTATAATAACTCATGTAGCATTAACTCACGACGCTCTTTACTTTACGACTAAATACGGCGAGGCGTTCATTGGCAATATATCGCGCAAAGCCACGTCCCCTCCCGTTCAACCAATCAGGAAAGAGAGGGAAAGAGACAACAAATCTGCCCTAGTGAAGTTTCTAGAAAAGGACGACTGCACGTCTGTAAGGATCACCAAAATACCAAATGTACATAGGGCGGTGGAAATTGCAGTTGATAGTGAAGGACTCAATTTTGCATGTCTTCAGACGAAACCAACGTGTGGTTTGACACCTTTACCAGATTTATCGGCATCCTGTCTTACCAAACATATGGAATCTCTTTTTGAGACTGCCGCTGAGGACGATATCTTACATGATGTTATATTCAAGgTTGGTCAAAAACAATATCCCGCCCATATATTCATAATCGCCTCAAGTAGTGACTACCTCTACAAATTGTACCAAGAAAACAGCACAAATACGCACAAACCGACAATAAGTCTAGATAACGTTCACCCAGAGGTCTTTGAAAGGATCCTAAGATATATGTACACAGGTACTTGTGACGTCACTGAGTTAGGCCCCTGTGGCTTAAAAATAAGGAGGGAGGATTTAATTGGTGCGAAGAAAGAGAATATCGACACTGAAGATGTCATAGataATCCAACAGAGATATCAGCATTCGAAGTGTACAAAAACCAAGACAAAAAGAAAGGCCGTCGTCGTAACACTGAGACACCTCCACGTGTGAATATGTATTGCAACCCAATCAAGTTAGTTCAAGCTTCGGCTAAGAGATTGCATGTAATGGGCTTGCATAAACTTCTCGACAAATTCTTttACAAGGATGGCGCGGTGTGTCTCAAAGAAAGTGCAACATATACAAAGAATATTCTCACATGGGACCGGGATATGTTTCCGGAGTTAGTTGATACCAACGTCTGTTCAAAGGATGGTATGCTGATATCGGCTCATAAATGTGTATTGGCGGCCAGGCTTGAGTACTTTCAAGGAATGTTCATGCACTCTTGGACTGAGAGTAAGGTTCTATCAAAAGTCACACTACCAATAAACTATGGAATACTACTACCAGTCATTAACTTCCTATACACGGATACCTGTCCAGAAGTTGAGAGATCAGACAGCATTGACTTTATATGCAGCATGCTCATAGTATCCGACCAGCTCTTCATCAGCAGATTGAGGGAAATGTGCGAAATAGCATTATCTAATCTGATCACATTGAAAAATTGCACAGAACTGTGCCAATTTGCACACACATACAATGCTAATCAACTGAAACAATGTTGTATggaatatatatctttaaacttATCCAGCATCCTTGAGAACAGATCCTTGGACCTCTTAGAAGACACTTTACTGCAAGATATAACTAAGTATTACTGCAAATTCAACCCCATAATGTCTTCAAGAATTGTCACTCCATTTTTCAACTCGCCCACTGATGAAATTATCGATGAATGCGTTAAAAACTTGCCAGTAGATCTAGAGGTAATTGACGAAGATGTCAAAAGAGATGACAGTATCATAGAGATAAGTAAAAAGAAGAAACAGAAGAAGATAGAGTATACAGAGAGTGAGAAGGCGAGGATGAGATATGAATCAGTCAGTTCGGTGACCTCATTAGACTTGTCAAACGATACGTCCGGTGACGTCACGTTGTCCCTTACCGCGATTCCAAAGAGTGGGGAAAAGAAAACCCGTGAAACAGAAAAATGGACAGAAGTACCAACATCTCAACAAAAACAGCAGAAAGTTGTTCAAGCTCGCCTCAAAGCCATATCTATAGCCAAGGATATATTAAATGAGCCACCTACAAATTCTTTcacaaaactaattaaaaataactctttTAATACCAATAATCAAGAACCCATTATACCAACAACCTCTCGTCAAATGTCAGTGTCTCCTAAGGAATCTGAATTTTGTTGGGGTCAAAGTAATCTGGTTATTAGCCATGTTGGCCCAAAACTATCTCAGAAACAGCGGAAGAAATTAGCATCAGAGAGTGAAAAGAGTCCCCAAACTTTGGATAGCTATCTATCCAATAAACTTAACATTGGTAGTCCACCGGACAAACCAAAAAATCCATGGAAAATCTGTGAAGCACCCATAGCTCAAAGTAGcccaaataaacaaaatgccATGGAGTTTAATAAGATTTTGGCCGATCAAAAAAAGCAAAAGGATGATTCTTCAAGGATAATGACTAAATCTCTTACTTTGACTCAGctCGAAGATAAAGCGATTGAGGAATTGGAGCGGTTTTACAATGTACATGAAGCTGATGATGAATTGATAACAGTAAGGCGCATAGAATTGCAAGTGTCCTCTCCCCAATGGATCAACACTGCCCCTAAGTGA
Protein Sequence
MNKTIEVDCTRRCKSRIHGQVLTSAITKRSISDESLASFIKSTCANFAKAFDFEGRTALHMTASRGRNDLMEWLVRHSSDAFINARDRESGYTPLHRSIFYGQIHSAVTLMKLGVNTDIQDKDDYKAIEHAMLDKHYMYKQTGSEPCDAYVWGSNTNYTLGTGSQQPKNIPDLLGCFSRANANLRQVCLGKFHSVWVCGSNDNGEVWCAGQPARAGGPHTTALRPTPLKLPEPCLQVAITLTSTVFLLQSGAVIQYTLNNTENPSPSSVKSPSTIKLASVKPLIKLSQPLGVSAGRSHAVVWNKNAVYTWGLNLGQLGHPQEEKVIQAPKRVGISLNNKEESSLQLVDATDAATVITTSRGDVYLLHRYLCKKIAVKQINLKQVCVEAKVNEQGSYSRVTVLLLTNVGQLMLWQDTTNKLTRCVFGLNHQTIITHVALTHDALYFTTKYGEAFIGNISRKATSPPVQPIRKERERDNKSALVKFLEKDDCTSVRITKIPNVHRAVEIAVDSEGLNFACLQTKPTCGLTPLPDLSASCLTKHMESLFETAAEDDILHDVIFKVGQKQYPAHIFIIASSSDYLYKLYQENSTNTHKPTISLDNVHPEVFERILRYMYTGTCDVTELGPCGLKIRREDLIGAKKENIDTEDVIDNPTEISAFEVYKNQDKKKGRRRNTETPPRVNMYCNPIKLVQASAKRLHVMGLHKLLDKFFYKDGAVCLKESATYTKNILTWDRDMFPELVDTNVCSKDGMLISAHKCVLAARLEYFQGMFMHSWTESKVLSKVTLPINYGILLPVINFLYTDTCPEVERSDSIDFICSMLIVSDQLFISRLREMCEIALSNLITLKNCTELCQFAHTYNANQLKQCCMEYISLNLSSILENRSLDLLEDTLLQDITKYYCKFNPIMSSRIVTPFFNSPTDEIIDECVKNLPVDLEVIDEDVKRDDSIIEISKKKKQKKIEYTESEKARMRYESVSSVTSLDLSNDTSGDVTLSLTAIPKSGEKKTRETEKWTEVPTSQQKQQKVVQARLKAISIAKDILNEPPTNSFTKLIKNNSFNTNNQEPIIPTTSRQMSVSPKESEFCWGQSNLVISHVGPKLSQKQRKKLASESEKSPQTLDSYLSNKLNIGSPPDKPKNPWKICEAPIAQSSPNKQNAMEFNKILADQKKQKDDSSRIMTKSLTLTQLEDKAIEELERFYNVHEADDELITVRRIELQVSSPQWINTAPK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01507342;
90% Identity
iTF_00213660;
80% Identity
-