Basic Information

Gene Symbol
-
Assembly
GCA_947563465.1
Location
OX387371.1:821486-839662[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 7.5e-06 0.00055 21.0 1.6 1 23 200 222 200 222 0.98
2 12 0.59 43 5.6 2.3 1 23 272 295 272 295 0.93
3 12 0.0086 0.63 11.4 0.6 2 21 302 321 301 325 0.90
4 12 0.7 51 5.4 3.3 1 23 329 351 329 351 0.86
5 12 0.00013 0.0096 17.1 0.7 1 23 356 379 356 379 0.96
6 12 0.00076 0.055 14.7 0.1 3 23 386 407 385 407 0.96
7 12 0.00012 0.0087 17.2 0.1 1 20 417 436 417 438 0.95
8 12 0.00019 0.014 16.6 0.5 2 23 477 499 477 499 0.94
9 12 0.0032 0.23 12.7 0.3 2 23 516 537 515 537 0.95
10 12 7.8e-06 0.00056 21.0 6.2 1 23 543 565 543 565 0.99
11 12 0.00011 0.0079 17.4 0.2 1 23 571 594 571 594 0.97
12 12 8.5 6.2e+02 2.0 0.0 2 9 600 607 599 621 0.85

Sequence Information

Coding Sequence
ATGCCTCTAATTAAAACTGAAAATAATGAAAATTCACACGAAGAAGCTAAGTGCGCCGAAGTGTATATAGAAAGCGAAAATTATGTAAAAAAAGATGCTAGCGACGTAGACAAGTGTACTTTAGAATTGCCAATAGAAAAAAGAGAAAGATCTGGAAGCAAGGTAGTCAAATCGAGAACGAAAAATACTGAATGTATCAAAGTCGAAGTTGAAATTGAAAATGATAACGCACATTCAGAATTAGATGATTGCATTGGATCTGAAGTGGGAAATGATACCAGTGACGTTGACACGGACGCATCGGAAGAAACACTTGCTGCAGTCAGAAATCGTAAAAGAACAAAAATAACTTTGACAAAAAATAATACGGCTAAACGTCCAAAAAAACCTAGAAACTTACTAACTGAAGATAAACATCCAACTGAAATAAATACCGATACATCTGAAGCAACAACTGGGTTAAACAAAACGGTTGGAATTAAATCTGTAGGTGCGGAAACAGCGTTCGAGAAGAAAAATAATCGTAACACAAAAGCTTTGGATACAGACGTAAAGAAACCAAAGTTACAGAAGAGGAAAAGGAGGAACAAGTCCATATACAGCTGCGACTTGTGCGGGAAGGAGTACAAGAGTGAAAGTAATTTGAAGACACATAAGAGTCGTCATGACCCGAATATGTCGAAAGAAACAATAGCTACATTAAAAAAAGATGCCGATTTAGAGTTTGAGAAAAAGTATAACTTTGAAATAAAACTGTTGAGTAAAGAAGAACAGAAACAGAGGATAGAAGAGAGGAAAAAGAACATGTCTGCGCACAGCTGCGACGTCTGCGGGAAGGACCACAACAAGGAAAGTACTTTAGCAGCGCACAAGACTTCTTACCACGACCCGAGTCTGCCGGTGGAGTGCGACGTGTGCTTCTACCGGTTCCGGAGCCGCCAGGTGTTGCGGAAGCACCAGCTCGAGGACCGCCACCGGGCCACCTTCACGTGCAACGAATGCGGCCATGTCACCCGGAGCAGAATGTATGCGAAAGACCATTGTCTCATGCACCGAGGCAAAACCTTCGCTTGCCCCTACTGCGACATGAAGTATGATCGCCAGAGCTCGTACTACGGACACATGCGACTGCAGCATCCCGGGGAGAACGAGGCGTGCGACGAGTGCGGCGAGACCTTCACCGGGAAGGTGGGGTTGTTGGTGCACAAGCGGCTGCGGCATAAGACTAACGACAATCCAAATGGAAACTTCAAATGTTCAGTTTGCGAAGTCAAGTTTTCGAGCCCCGAAGCGCTGCAAAGGCACTTGGAGCTGAGTGTCGGCGTGCCGCATGCGGCGCTGTGGCCCTGTGCCGCATGCGGCGACACTTGTGGCAGCGAGCCCGCGCTCGCCGCACATGCCGCAGAGAAACACCCGCCCGATCAGCGTTACTGTAAAGAGTGCAACAAGACGTTCGCGGACGCTTCCTCGTTCGCGCTCCACGTGGACAGGAAACACAAGAACCGGCGCGCGGCGTACGTGGTGCGCGTGCGGCGCGGCCGCATCGTCTGCGAGATATGCGGCAAGGTGTTCATGTGCCTGGCGACTCTGCAGTACCACATGAACGGGCACTTGGGTCTCAGGCCGTTCCAGTGCTCGCACTGTTCCAAGGCATTCACTCACAAAACAAAACTTATGTTACATATGCGTGTGCATACGGGCGAGAAGCCCTATCAGTGCGAACAGTGCCCGCTGGCTTTCTCTGCGCGAGGGAACTTCACGAGGCACGTGAAAAACGTACATTTGCGGGTGCAGGTGGAGTGCGAGACGTGTGGCAAGACGATGGGCGCGGGTTCGCTCCCGGCGCACGTCCGCGCCGTGCACATGAACCAGCCGTACGTGCGTCGGAAACGGGACCGCACCGGCAAGACCCAAACCCGCATTAGAGAATCGTAA
Protein Sequence
MPLIKTENNENSHEEAKCAEVYIESENYVKKDASDVDKCTLELPIEKRERSGSKVVKSRTKNTECIKVEVEIENDNAHSELDDCIGSEVGNDTSDVDTDASEETLAAVRNRKRTKITLTKNNTAKRPKKPRNLLTEDKHPTEINTDTSEATTGLNKTVGIKSVGAETAFEKKNNRNTKALDTDVKKPKLQKRKRRNKSIYSCDLCGKEYKSESNLKTHKSRHDPNMSKETIATLKKDADLEFEKKYNFEIKLLSKEEQKQRIEERKKNMSAHSCDVCGKDHNKESTLAAHKTSYHDPSLPVECDVCFYRFRSRQVLRKHQLEDRHRATFTCNECGHVTRSRMYAKDHCLMHRGKTFACPYCDMKYDRQSSYYGHMRLQHPGENEACDECGETFTGKVGLLVHKRLRHKTNDNPNGNFKCSVCEVKFSSPEALQRHLELSVGVPHAALWPCAACGDTCGSEPALAAHAAEKHPPDQRYCKECNKTFADASSFALHVDRKHKNRRAAYVVRVRRGRIVCEICGKVFMCLATLQYHMNGHLGLRPFQCSHCSKAFTHKTKLMLHMRVHTGEKPYQCEQCPLAFSARGNFTRHVKNVHLRVQVECETCGKTMGAGSLPAHVRAVHMNQPYVRRKRDRTGKTQTRIRES

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00155698;
90% Identity
iTF_00155698; iTF_00156570;
80% Identity
-