Basic Information

Insect: Archips xylosteana
Gene Symbol: gsb-n
Assembly: GCA_947563465.1
Location: OX387358.1:11106972-11126120[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1e-70 3.2e-67 225.0 1.0 1 125 13 134 13 134 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1e-70	3.2e-67	225.0	1.0	1	125	13	134	13	134	0.99

Sequence Information

Coding Sequence: ATGGAACGCCACCAGAATGGTATGGATGTGTGGGTAGGGCAAGGACGCGTCAACCAATTAGGTGGCTTATTCATCAATGGAAGGCCGCTACCTAACCACATCCGTCTAAAGATTGTGGAGATGGCGGCGGCTGGCGTAAGACCCTGCGTCATCTCGCGGCAGCTGCGTGTCTCGCACGGATGTGTCTCCAAGATCCTCAATAGGTACCAGGAGACCGGTTCCATTAGACCGGGCGTGATTGGAGGCTCGAAACCCAGAGTAGCCACGCCCGAGGTGGAGTCCAGGATCGAGGATCTGAAGCGCCAGAACCCAGGAATATTTTCCTGGGAAATCCGAGAGAAATTAATAAAGGAAGGCGTGTCAGACCCGCCCAGCATCTCCTCGATATCGCGGCTGCTGCGAGGCGGCGCGCGCGACCCCGAGGGCAAGAAGGATTACAGCATTGACGGCATCCTAGGAGGTCGAGGATCAGACTCTTCAGACATCGAATCAGAGCCAGGATTGACGCTGAAGAGGAAGCAGCGCAGGTCCCGTACTACGTTCACAGGCGAACAGTTGGACGCTCTAGAGAGAGCTTTCCATAGGACCCAGTACCCTGATGTATATACTCGCGAGGAATTGGCGCAGCAGACTGGACTCACCGAAGCTAGGATACAGGTGTGGTTCTCAAACCGGCGAGCAAGACTCCGCAAGCACACCGGATCCAATACAGCGCCCAGCTTAGCCAGCTACTCCACACTGCCAATGCCACAGATACCATGCCCTTACCCTGCTGGCGAGATTCCATCTCTCTCACAACATCATCCACAGCATGCTGACGCTTGGCACCACCAAAAGTATTCCAACTACAATCAACTTATGGCGCAATCCCAACATCTAAACCAAGCTTTCCAAAGCGCTGCTTTTCCAAGCACTTCTGGAGCAACATTCGGCCATCTAATGGCCGGAGCGAATGGATCTCCTCATAGCCAAATACTAGATCCTGGCGTACCTAGAAATGACTACGCCAGATACGATGTCTATAATAAACCTGTCAACTACTTACCCAAAGAAACTGAAGATGATAAATTAGCGAGTGAAGAAATTATTGAGCCGAGGGAAGATACCTTTGTTAAGCCTTCGGCTGAGGAATACAATAAATCATTACCAGCTAGTGATTACAAAGTACCTGCTGATTACTCTAAGGTGCCGGGGGATCCAACTCCTACAAACTGGAGTCCTTCGCATAATTCTTTGAATATGAGCCTCGCTGGCCTCTCCGGAGAATACAAGTACATGAATGAGCCCTACGCCTTCCCCAACATACCTGATCCCCTCACTCAGCACAACTACTCCAGTCCCCCAAACGCTCCCAGCAAATACTGGATTTGA
Protein Sequence: MERHQNGMDVWVGQGRVNQLGGLFINGRPLPNHIRLKIVEMAAAGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPRVATPEVESRIEDLKRQNPGIFSWEIREKLIKEGVSDPPSISSISRLLRGGARDPEGKKDYSIDGILGGRGSDSSDIESEPGLTLKRKQRRSRTTFTGEQLDALERAFHRTQYPDVYTREELAQQTGLTEARIQVWFSNRRARLRKHTGSNTAPSLASYSTLPMPQIPCPYPAGEIPSLSQHHPQHADAWHHQKYSNYNQLMAQSQHLNQAFQSAAFPSTSGATFGHLMAGANGSPHSQILDPGVPRNDYARYDVYNKPVNYLPKETEDDKLASEEIIEPREDTFVKPSAEEYNKSLPASDYKVPADYSKVPGDPTPTNWSPSHNSLNMSLAGLSGEYKYMNEPYAFPNIPDPLTQHNYSSPPNAPSKYWI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00289579;
90% Identity: iTF_01464127;
80% Identity: iTF_00156095;