Basic Information

Gene Symbol
-
Assembly
GCA_947859365.1
Location
OX402072.1:175249-179541[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.15 10 7.4 2.3 1 23 117 137 117 137 0.91
2 18 4.4e-05 0.003 18.5 2.3 1 23 156 178 156 178 0.98
3 18 1.7e-05 0.0012 19.8 0.2 1 23 205 227 205 227 0.96
4 18 0.04 2.7 9.2 0.0 2 21 234 253 233 254 0.94
5 18 0.064 4.3 8.6 0.2 1 20 327 346 327 348 0.93
6 18 9.4e-05 0.0063 17.5 1.0 2 23 355 376 354 376 0.96
7 18 0.0002 0.014 16.5 1.8 1 23 382 405 382 405 0.97
8 18 0.25 17 6.7 6.4 1 23 411 433 411 433 0.96
9 18 0.028 1.9 9.7 3.4 1 23 442 464 442 464 0.96
10 18 0.0002 0.013 16.5 0.4 1 23 470 492 470 492 0.98
11 18 2.9e-05 0.002 19.1 0.7 1 23 498 520 498 520 0.98
12 18 2e-05 0.0013 19.6 3.0 1 23 526 548 526 548 0.99
13 18 2.5e-05 0.0017 19.3 1.8 1 23 554 576 554 576 0.97
14 18 0.00033 0.022 15.8 0.4 1 23 582 604 582 604 0.97
15 18 9.8e-05 0.0066 17.4 0.7 5 23 613 631 611 631 0.96
16 18 4.4e-06 0.0003 21.7 1.7 1 23 637 659 637 659 0.97
17 18 0.00012 0.0081 17.2 2.2 1 23 665 687 665 687 0.98
18 18 0.00014 0.0097 16.9 0.0 2 23 694 715 693 715 0.96

Sequence Information

Coding Sequence
ATGTCGGAATGCGTCCGAGTGAAAGAGGAGCCGGCATGGGAGGCCGAGGGCGCTGGGCCGCTGTGGGCCGCACTCACCGCACTGGGCGCCCCCGCGGCGCTGAAGCGGGAGCTCGGGCTCGGCGACGGTGCATACGCTGAGGACGTAGACTTCGCGTTACCAGATGCAAGTTATCCAGAAACCGACACCAGCTCTGAACCAGACACAAAAGACGTAAAGGCAGCCGCTGCAGCCTCACACTCCGACCCTGGAGACACAGGTAAAGAGCGCGAAAGCCCAGACCTCCACAAACCTATTGACATTAAGCCTTGCTTCACCAAACTAGGACGCAAAAACCAAGTGAAAACTTTCGACTGCCCCATCTGCCACAAGCGCACGAAGAGAGAAATTAAGCGACACATCCTCACTCATACTCAGGAGGAAATCGACAGCATCAAAACTGTCAAGAAGACTGGGAAAGGAAAATTTAAATGCCATATCTGCGGCGCGAGACTAGCACGCCGTTTCAGTTTGAAGAAGCATCTAAAAATCCATGCTAGAGTATCTAAACTGGATCCTTTTCAGCAGCAACTGTATAGGAAACGTCCTAAGAAGAAATATGTGAAGAGCGTCTTTGAATGCGACGTGTGTGGGAAGCAAACGACTAGGAAAGAGAGCCTGGCGAGGCATCTGGAAGGGCATGCCGACGACGAACCTGTTGTCTGTGGACGCTGCAATGAACCATTCAAGTATACGTGGGAACTTGTGAATCATATAAAGCTTGCAATTTGCACAGAAAATGTTAGAGTCGCTCAAAATGTTAAGAAAATTCCGGAGGTTCAGTTGAAACAGTGTGTTATAAGACTTCAACGTTTAGACGACAATGACAATAATGCTTTGAAAAGCATCGGTAAAGTTCCTGAAGTTAGCAGTGAAAATTTAAGCGATGAAGATGTAGCGTTAGATGACACAGGTGCTCTAGAGACCGAGGAAGAAACGTACTACTGCGGCGTTTGCGAGGAACAGTTCGAGACTTTGTCCTCGTTAGGTGACCATGTCTGCGGACGGCCAAAGAAACCAGTGTCGTGCGAGATTTGCAAGAAAAAGTTTAAATTCCGAGCTGATTTGGTCACACACACCCGTCTACACACAGGTGAGAAACCATTCACTTGTGACGTGTGTAAGAAGACATTTCGGTTGAAGCAAAGCATGAAATTGCATATTACGACAGTACATTTGGGCGAGAATCCCTTCTCCTGCAAGATTTGCAAGAAGAAGTTCCGTTGCTCTCAAACACAGCAAAAACACGTCCGCGAACATACGGGGGAGAAGGAGAAGAAGCTGTACTCGTGCAAAGTGTGCAAGAAGAAGTTTAAGTTTGAGAGCGAATGCATCGAGCACGGCCGAGTGCACACAGGGGAGAAACCGTTCACCTGTACTGTGTGCAATATGAGATTCCGAGTGGCAGTTGCTTTGCGCACCCACAGTCGGGTCCACACAGGTGAGAAGCCGTATTCGTGCGACGTGTGTAAACGATCGTTTCGTATTTGGCAAACGTTGAACGCTCACAAACGCGTGCACACCGGAGAAAAACCGTTCCAATGCGACGTCTGCGACAAACGGTTTAGGACGTTGCATGCTGTGAAGATTCATAAAAGGACACATACTGGAGAAAGGCCGTTCGCTTGCGAGTTCTGCCCGAAGCGCTTCATACAGTCAGGCCACTTGTACACGCATCAGAAAGTGCACACTGGCGAGAAACCCTTCGCCTGCACGGTTTGTGACAAAAGGTTTGCGGAGAGGAGTAAAATGGTTGCCCATAGCCGGTCCCATAGCGAGGAGAAACCTTTCTCATGCATTTGCGGGAAAGCTTTTAAAACTGCAAGCGCTCTCAAGACGCACAGGAAGCTCCATACGGGGGACAAGCCGTTCGCTTGTGAGGTGTGTAAGAAGGCTTTCGTACGGAAGAGTCATGTGAAGGATCATATGCAGAGCCATACCAAGGAGTGGCCGTTTGAGTGTGAGCTCTGCCAGCGGAGGTTCCAGAGGCGGGATTACCTCCGGCTGCATAGGAAAGTGCATGGCGGCGCTCCATGTCTCGTGTGTGACGTTTGCGGGGCCAAGTTTGGGGACTCCGGGGAGTTGAGGGTGCATTTACGCGGTCACGATGTTGAgtga
Protein Sequence
MSECVRVKEEPAWEAEGAGPLWAALTALGAPAALKRELGLGDGAYAEDVDFALPDASYPETDTSSEPDTKDVKAAAAASHSDPGDTGKERESPDLHKPIDIKPCFTKLGRKNQVKTFDCPICHKRTKREIKRHILTHTQEEIDSIKTVKKTGKGKFKCHICGARLARRFSLKKHLKIHARVSKLDPFQQQLYRKRPKKKYVKSVFECDVCGKQTTRKESLARHLEGHADDEPVVCGRCNEPFKYTWELVNHIKLAICTENVRVAQNVKKIPEVQLKQCVIRLQRLDDNDNNALKSIGKVPEVSSENLSDEDVALDDTGALETEEETYYCGVCEEQFETLSSLGDHVCGRPKKPVSCEICKKKFKFRADLVTHTRLHTGEKPFTCDVCKKTFRLKQSMKLHITTVHLGENPFSCKICKKKFRCSQTQQKHVREHTGEKEKKLYSCKVCKKKFKFESECIEHGRVHTGEKPFTCTVCNMRFRVAVALRTHSRVHTGEKPYSCDVCKRSFRIWQTLNAHKRVHTGEKPFQCDVCDKRFRTLHAVKIHKRTHTGERPFACEFCPKRFIQSGHLYTHQKVHTGEKPFACTVCDKRFAERSKMVAHSRSHSEEKPFSCICGKAFKTASALKTHRKLHTGDKPFACEVCKKAFVRKSHVKDHMQSHTKEWPFECELCQRRFQRRDYLRLHRKVHGGAPCLVCDVCGAKFGDSGELRVHLRGHDVE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00156459;
90% Identity
iTF_00156459;
80% Identity
-