Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.001 12 7.8 0.0 23 44 93 114 80 118 0.87

2 8 0.021 2.4e+02 3.6 0.2 21 44 119 142 117 146 0.88

3 8 0.00088 10 8.0 0.1 21 47 147 173 142 178 0.85

4 8 0.0015 17 7.3 0.0 21 45 175 199 172 205 0.89

5 8 4.4 5.2e+04 -3.9 0.3 26 30 208 212 207 214 0.86

6 8 0.017 2e+02 3.9 0.1 21 44 231 254 223 258 0.88

7 8 0.00082 9.6 8.1 0.0 21 44 259 282 255 291 0.83

8 8 0.11 1.3e+03 1.2 0.1 21 52 287 317 285 318 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.001	12	7.8	0.0	23	44	93	114	80	118	0.87
2	8	0.021	2.4e+02	3.6	0.2	21	44	119	142	117	146	0.88
3	8	0.00088	10	8.0	0.1	21	47	147	173	142	178	0.85
4	8	0.0015	17	7.3	0.0	21	45	175	199	172	205	0.89
5	8	4.4	5.2e+04	-3.9	0.3	26	30	208	212	207	214	0.86
6	8	0.017	2e+02	3.9	0.1	21	44	231	254	223	258	0.88
7	8	0.00082	9.6	8.1	0.0	21	44	259	282	255	291	0.83
8	8	0.11	1.3e+03	1.2	0.1	21	52	287	317	285	318	0.83

Coding Sequence: ATGAAGGAGGAGGTACCAAGCGAAGAGGAACCTAAGTGGACGAACAGCGCAGACTCAAGTGGGGGATCACAGCCCGTTGGATCCACGACATGTCATGGCTCATTAAAGAAAGCAAAAGGCGGGCAGCCAGTTACACCAACCACATCTACAGCACGCAAGCGGAAACTACGGAAACCAGTACCCACCATCGACAAGCCACATGTCTGCGAGTTCTGTAAAAAAGAGTTCAAGCTGTTAGGTACTTTAAGGACACACCAGAGAATCCACACAGGAATAAAACCATACGATTGCGATATATGCAAAAAGGAATTCACGCAATCGACCTCTTTGAAGCGACATATTCTTATACACACAGGAGAGAAGCCACACAAATGTGAAATATGTCGAAAACAGTTTACGCAGTTCAGTCATTTTAAAAGACATAAGCGAATACATACGGGAGAGAGACCTTATTCTTGTAATATATGCGATAGGGTATTTTCCGAATCGAGCACTTTGAATAAACATAAATTACTTCACACTGGTGAGAAACCTTATACATGTGGAACATGTAAGAGGATCTTCACTCAGCTAGGCAATCTGAAGACGCATCAACGAATTCACAACGAAGGGAAAATATACACTTGTGAAATTTGTTTGGAAAAGTTTACTGTTTTCTTGGAGTTTAAATCACACAAGAGAGTTCACGCCGGAGAAAGGCCTTATTCCTGTGATTTGTGTAAAAAGAGTTTTCCGAAACTGGCTAATTTGAGGGAACATATTAGAActcactcgggagaaaagccgtttAGTTGCGATATATGTCATAAGAAGTTTACACAATCGGGCGCTATGAAAAAACATAAACTGATTCATACGGGGGAGAAGCCATTCTCGTGCTGTTTGTGTCTGAAACGGTTCACTGAAAAGGGCAGCATGATGCGGCACGTGCTGACTCATACCAAAAAACCGACGTGA
Protein Sequence: MKEEVPSEEEPKWTNSADSSGGSQPVGSTTCHGSLKKAKGGQPVTPTTSTARKRKLRKPVPTIDKPHVCEFCKKEFKLLGTLRTHQRIHTGIKPYDCDICKKEFTQSTSLKRHILIHTGEKPHKCEICRKQFTQFSHFKRHKRIHTGERPYSCNICDRVFSESSTLNKHKLLHTGEKPYTCGTCKRIFTQLGNLKTHQRIHNEGKIYTCEICLEKFTVFLEFKSHKRVHAGERPYSCDLCKKSFPKLANLREHIRTHSGEKPFSCDICHKKFTQSGAMKKHKLIHTGEKPFSCCLCLKRFTEKGSMMRHVLTHTKKPT*

Sequence clustering based on sequence similarity using MMseqs2