Basic Information

Gene Symbol
PAX1
Assembly
GCA_905147355.1
Location
LR990298.1:21307101-21311335[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 7.4e-68 3.6e-64 216.0 0.2 3 125 28 150 26 150 0.99
2 8 0.00023 1.1 10.8 0.0 99 125 233 259 212 259 0.88
3 8 0.09 4.4e+02 2.4 0.0 104 124 353 373 327 374 0.81
4 8 0.11 5.4e+02 2.2 0.0 104 125 496 517 482 517 0.86
5 8 0.052 2.6e+02 3.2 0.0 111 125 648 662 638 662 0.88
6 8 0.24 1.2e+03 1.1 0.0 108 125 700 717 694 717 0.84
7 8 0.0062 31 6.2 0.0 99 125 778 804 760 804 0.88
8 8 0.02 99 4.5 0.0 105 125 886 906 873 906 0.88

Sequence Information

Coding Sequence
ATGCCTGATTACTTTGTATTTGTCCATGCAGATCCAAGCGGAGGGTCTCTCGGCGGCGCGGTGGGCGGGTCGCAGCAGTACGGCGAGGTGAACCAGCTCGGCGGCGTGTTCGTCAACGGGCGGCCGCTGCCGAACGCCGTGCGCTTGCGGATAGTCGAGCTGGCGCAGCTTGGGATAAGGCCCTGCGACATCAGCCGGCAGCTACGAGTGTCCCACGGCTGCGTGTCCAAGATCCTGGCGCGATACCACGAGACCGGGTCCATCCTGCCCGGCGCCATCGGCGGCTCCAAGCCGCGTGTCACCACGCCGAAGGTGGTGTCATACATAAAGCAACTGAAAGCAAAAGACCCCGGCATCTTCGCGTGGGAGATCCGCGACCGACTCCTGGCGGACGGCGTCTGCGACAAGTACAACGTGCCATCCGTGTCGTCCATATCCCGCATCCTGCGCAACAAGCTGGGCGGCGCGCTGTACCCCGTGCCGCCGCTGTACCCCGTGCCGCCGCAGCGCTGCTGGCCGCTGCACCAGCCCTACGACTACTACGTCTATCTACAGGTTGGTACAGTACAGCAAGCACAACGTGCCCTCCGTGTCGTCCATATCCCGCATCCTGCGCAACAAGCTGGGCGGCGCGCAGTACCCCGTGCCGCCGCTGTACCCCGTGCCGCCGCAGCGCTGCTGGCCGCTGCACCAGCCCTACGACTACTACTTCTATCTACAGGTTGGTACAGCAAGCACAACGTGCCCTCCGTGTCGTCCATATCCCGCATCCTGCGCAACAAGCTGGGCGGCGCGCAGTACCCCGTGCCGCCGCTGTACCCCGTGCCGCCGCTGTACCCCGTGCCGCCGCAGCGCTGCTGGCCGCTGCACCAGCCCTACGACTACTACGTCTATCTACAGGTTGGTACAGTACAGCAAGCACAACGTGCCCTCTGTGTCGTCCATATCCCGCATCCTGCGCAACAAGCTGGGCGGCGCGCTGTACCCCGTGCCGCCGCTGTATCCCGTGCCGCCGCAGCGCTGCTGGCCGCTGCACCACCCCTACGACTGCTACGTCTATCTACAGGTTGCTACAGCACGCACAACGTGCCCTCCGAGTCGTCCATATCCCGCATCCCACGCAACAAGCTGGGTGGCGCGTTGTACCCCGTGCCGCCGCAGCGCTGCTGGGCGCTGCACCAACCCTACGACTACTACGTCTATCTACAGGTTGGTACAGCAAGCACAACGTGTCCTCCGAGTCGTCCATATCCCGCATCCTACGCAACAAGCTGGGTGGCGCGTTGTACCCCGTGCCGCCGCAGCGCTGCTGGGCGCTGCACCAGCCCTACGACTACTACTTCTATCTACAGGTTGGTACAGCAAGCACAACGCTCCCTCCGAGTCGTCCATATCCCGCATCCTACGCAACAAGCTGGGCGGAGCGCTGTACCCCGTGCCGCCGCAGCGCTGCTGGCCGCTGCACCAGTCCTACGACTGCTACGTCTATCTACAGGTTGGTACAGCAAGCACAACGTGTCCTCCGAGTCGTCCATATCCCGCATCCTACGCAACAAGCTGGGTGGCGCGTTGTACCCCGTGCCGCCGCAGCGCTGCTGGGCACTGCACCAGCCCTACGACTACTACGTCTATCTACAGGTTGGTACAGCAAGCGCAACGTGTCCTCCGAGTCGTCCATATCCCGCATCCTACGCAACAAGCTGGGTGGCGCGTTGTACCCCGTGCCGCCGCAGCGCTGCTGGGCGCTGCACCAGCCCTACGACTACTACGTCTATCTACAGGTTGGTACAGCAAGCACAACGTGTCCTCCGAGTCGTCCATATCCCGCATCCTACGCAACAAGCTGGGTGGCGCTTTGTACCCCGTGCCGCCGCAGCGCTGCTGGGCGCTGCACCATCCCTACGACTACTACATCTATCTACAGGTTGGTACAGTACAGCAAGCACAAACGTGCCCTCCGAGTCGTCCATATCACGCATCCTACGCAACAAGCTGGGCGGCGCGTTGTACCCCGTGCCGCCGCTGTACCCCGTGCCGCCGCAGCGCTGCTGGCCGCTGCACCAGCCCTACGACTACTACGTCTATCTACAGGTTGGTTGGTACAGCAAGCACAACGTGTCCTCCGAGTCGTCCATATCCCGCATCCTACGCAATAAGCTGGGCGGCGCGCTGTACCCCGTGCCGCCACTGTACCCCGTGCCGCCGCAGCGCTGCTGGCCGCTGCACCAGCCCTACGACTACTACGTCTATCTACAGGCTGGGCGGCGCGCTGTACCCCGTGCCGCCACTGTACCCCGTGCCGCCGCAGCGCTGCTGGCCACTGCACCAGCCCTACGACTACTACTTCTATCTACAGGTTGGTACAGCAAGCACAACGCTCCCTCCGAGTCGTCCATATCCCGCATCCTACGCAACAAGCTGGGCGGAGCGCTGTACCCCGTGCCGCCGCAGCGCTGCTGGCCGCTGCACCAGTCCTACGACTGCTACGTCTATCTACAGGTTGGTACAGCAAGCACAACGTGCCCTCCGAGTCGTCCATATCCCGCATCCTACGCAACAAGCTGGGTGGCGCGCTGTACCCCGTGCCGCCACTGTACCCCGTGCCGCCGCAACGCTGCTGGCCGCTGCACCAGCCCTACGACTACTATGTCTATATCTACAGGTTGGTACAGCAAGCGCAACGTGCCCTCCGAGTCGTCCATATCTCGCATTCTACGCAACAAGCTGGGCGGCGCGCTGTACCCCGTGCCGCCGCTGTACCCCGTGCAGCCCAACAGCCCTACGACTACTACGTCTATCTACAGATGTTTGAAGGCACCGAAAATTCACGTGTGTCCTCCACAGGGGCGGCAGCACGCAGGCGGGGCGCCGCACGGCCTCCACCCGCACCagcagcccgcgccgccgcatcacgcgcacgcgcacgcgctcTGA
Protein Sequence
MPDYFVFVHADPSGGSLGGAVGGSQQYGEVNQLGGVFVNGRPLPNAVRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYHETGSILPGAIGGSKPRVTTPKVVSYIKQLKAKDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKLGGALYPVPPLYPVPPQRCWPLHQPYDYYVYLQVGTVQQAQRALRVVHIPHPAQQAGRRAVPRAAAVPRAAAALLAAAPALRLLLLSTGWYSKHNVPSVSSISRILRNKLGGAQYPVPPLYPVPPLYPVPPQRCWPLHQPYDYYVYLQVGTVQQAQRALCVVHIPHPAQQAGRRAVPRAAAVSRAAAALLAAAPPLRLLRLSTGCYSTHNVPSESSISRIPRNKLGGALYPVPPQRCWALHQPYDYYVYLQVGTASTTCPPSRPYPASYATSWVARCTPCRRSAAGRCTSPTTTTSIYRLVQQAQRSLRVVHIPHPTQQAGRSAVPRAAAALLAAAPVLRLLRLSTGWYSKHNVSSESSISRILRNKLGGALYPVPPQRCWALHQPYDYYVYLQVGTASATCPPSRPYPASYATSWVARCTPCRRSAAGRCTSPTTTTSIYRLVQQAQRVLRVVHIPHPTQQAGWRFVPRAAAALLGAAPSLRLLHLSTGWYSTASTNVPSESSISRILRNKLGGALYPVPPLYPVPPQRCWPLHQPYDYYVYLQVGWYSKHNVSSESSISRILRNKLGGALYPVPPLYPVPPQRCWPLHQPYDYYVYLQAGRRAVPRAATVPRAAAALLATAPALRLLLLSTGWYSKHNAPSESSISRILRNKLGGALYPVPPQRCWPLHQSYDCYVYLQVGTASTTCPPSRPYPASYATSWVARCTPCRHCTPCRRNAAGRCTSPTTTMSISTGWYSKRNVPSESSISRILRNKLGGALYPVPPLYPVQPNSPTTTTSIYRCLKAPKIHVCPPQGRQHAGGAPHGLHPHQQPAPPHHAHAHAL*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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