Basic Information

Gene Symbol
PHF20L1
Assembly
GCA_963513935.1
Location
OY740773.1:1578116-1620964[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.2 1.1e+04 -1.6 0.1 22 39 412 427 408 432 0.74
2 2 1.8e-13 1.7e-09 39.5 0.2 9 72 468 526 464 530 0.87

Sequence Information

Coding Sequence
ATGGAGTCTGCAGGTGTTATGGGTACTTTGAGTGTTGAAAATCAAAAATACAGATCAACACAAATGGCTAAAAATCAAGAGATAATGAAGTGGGAATCTTGTGGAAGAAGATCATCAAGTGAAATGCGAAAAAATATCTCATGGGGTTCCAAGAACGATACAGATTCAGATTCTGACTCTTTAGTACTTGTGAAAATGAAGAAGTTAGGAAGACCAAGGAAGTTAGGTCCAAAGAAGGCGACTGTGACTAAAGAACTTCCACCTCAACATATGTCTGATGAGGATCTTCATTCACCAGACGAGCATAGTGATTCAAGTTTTAAGAAAAGTAGTGCTGAGGATGAAATTGATGATAAACAGTTTAGTCCTGGGAGTATTTTAGAAGTTATGGATTTCAATGAACAATGGTACCCTGTAAAGGTATTAGAAGTTGATTATGAAGAAAACGAGGTACTTGTGCATTACCAAAAATGGTCAGACCGATATGATGAATGGGTCCGAATGGACAGCAACAGGATTCGCCGTCCTAGTCCAGCCAGTTCCAGTTTACGACACAACTTCAAAGTTGGTGAGAAAGTAATGGCAACTTGGTCGTACAGTTTGAAGTTTCCAGCTGTTATAAAAGCATTGCATGATGATGATAAGGTTGATGTATTATTTTACGATGGTTTTGCAAAAACGTTGAGAAGCTGCAAACTGTCAAAAGCTAATGAACAAGATCTTAAAAATATGTCTgCTCCACGAGTTTACAAAGTTGCACCGCCTATTGGTTCTGATCCTGTTGAAACTGATCTGTGTTCAAAAGAAGAGCGAAGAGAAAGAAAGCGTAAAATTAATATTCTCGAAGTATTCCACCCACagttaaataaaaagagaaaaactgCAGGGATCCAAACAAAAGTAGAAGTGAAGAAACGAAAAAGACGGCGTTTTGCAAAACCTACGGCAACTATAAGTTTGAAGAAAGCAAGTGGAGTAGGTATTGCAGATCGTAAAGAGACAACGATAACTATAAAAGTTGAAAAACAGATTAAAGAAATTAGGAATGAAGTGAAAAATAATGACCCAGACATTAGTAAAACAAGTGTAAAACTAGAGACTCAAGAGGTAGAAGATAAAGAGCAAAAACCAGCTGTAAATGAAAACCTGCCAATCTCAAGTAATGTTGATTTTGAAGGTGATGCTGATGAGTCTACTCTGGTTATAGATGAAATACCTGAACAGGGAAGAAGAAGACGAAAAAAACGAAAGAAGaaagacATATCTTTTGTAGTTCCTCAAAAACGTAGGACACAAGATGAAGATGATCCTCGTTGGGATACTGATATTCCTGCAGGAGCAACTCCTTTCAAATTTGAAGCGTCAGATGGATCTGCAAGAGAATCTATTATAATACCTGACAAGAAGTTACCTGAAGGTTGGGCGAAACATACAATGCTTAGGAAAAACAGCTCTAAATGGGATGTTTTTCTTGTTAACCCTGAAGGTCGTAAATTTAGATCTCGAAATGAACTCCGAacttattataatgaaattaagGAGCCTTATCCAGAGgatcattttgattttgttgtggGACGAAAACAGCAGCTTATTGAAGACAGCAAAAACAAATCCAAAACCATTTCaCCATTGCCTCCTAAACCTTCAACATCGTCTACTGCTTTGCCTGCAGAAGTGAAGCGGATTAAAACTTTGTTACCAAAAAGTAAGCCTTTAGAGAATGAAGACAAAAGGGCAGTACCTCCAGCAGTTCCGGACGTTTCATCGCCATTACCCCTTCCTATGGAGTCATTACCTGTTACACCTGTACTTCCACCATTAAATATGAGTGTGTCATCACCAGGACAAGAAGGTTTTACCTGTCCTATAGATGGTTGTGGTAAAAACTTcagaaaagaaaatttgttacAGATGCATATCAAACATTACCACCAAGAATACAGTAACTTGGTCGGATCCACTCCCAATGTAGCAGATTTAGCTTATGCTCGGACTACAGGAGAACCTTTAGAAGACTCCCGAGCTGAGATGGCGTTAAATGGGACTTCATTTATAGATAGGATCAATCGTTTTGAAGCAGAACGTAAAGCTCGAGCGAGTGATGGTGTGCAAGCGTGGAATGTGTCTGCTGCCAAGAAACATGCTCTTAGAGAGTCACCAATACCGATGAACCCAAAGACTCCAGAAAGAGAAGCACTAGAAATAGCAGCACCTGAACCTCTAATGGTGGATGTTGGAGATGCTGATATTTCTTCATCAAGTATTGATTCTCCCGTTGTTGCAAGTCAAGTTTCTCCTAAGATGCCACCATCTTTGTCAACATTGTCAGTTCCGCCGCAGTCAGATGGAAATGTGTTGGATACAATTCCAAGTGAAGAACTAGCTCAACAAGTTTTTACAGAAATGTCTACCTCAACGAAAGGACATTCGACTTCAGGGAAAGAAGAGAAAAGTTCAACGATAAAAACCATATTACCTCTAAGACAACCTGTTCAAAATTCAGTTGAAATGATGGAGCTTATAATGGAAGAAGAGAGTGATGAAGATATGTTACATTATTCCACCTCCCCATCCAATAAGAGTTCTCAGAAAATACTCAAAAGTGAAGATTATCCTTCTGTAACACCAAAGAAAATGAAACCGGGTTAG
Protein Sequence
MESAGVMGTLSVENQKYRSTQMAKNQEIMKWESCGRRSSSEMRKNISWGSKNDTDSDSDSLVLVKMKKLGRPRKLGPKKATVTKELPPQHMSDEDLHSPDEHSDSSFKKSSAEDEIDDKQFSPGSILEVMDFNEQWYPVKVLEVDYEENEVLVHYQKWSDRYDEWVRMDSNRIRRPSPASSSLRHNFKVGEKVMATWSYSLKFPAVIKALHDDDKVDVLFYDGFAKTLRSCKLSKANEQDLKNMSAPRVYKVAPPIGSDPVETDLCSKEERRERKRKINILEVFHPQLNKKRKTAGIQTKVEVKKRKRRRFAKPTATISLKKASGVGIADRKETTITIKVEKQIKEIRNEVKNNDPDISKTSVKLETQEVEDKEQKPAVNENLPISSNVDFEGDADESTLVIDEIPEQGRRRRKKRKKKDISFVVPQKRRTQDEDDPRWDTDIPAGATPFKFEASDGSARESIIIPDKKLPEGWAKHTMLRKNSSKWDVFLVNPEGRKFRSRNELRTYYNEIKEPYPEDHFDFVVGRKQQLIEDSKNKSKTISPLPPKPSTSSTALPAEVKRIKTLLPKSKPLENEDKRAVPPAVPDVSSPLPLPMESLPVTPVLPPLNMSVSSPGQEGFTCPIDGCGKNFRKENLLQMHIKHYHQEYSNLVGSTPNVADLAYARTTGEPLEDSRAEMALNGTSFIDRINRFEAERKARASDGVQAWNVSAAKKHALRESPIPMNPKTPEREALEIAAPEPLMVDVGDADISSSSIDSPVVASQVSPKMPPSLSTLSVPPQSDGNVLDTIPSEELAQQVFTEMSTSTKGHSTSGKEEKSSTIKTILPLRQPVQNSVEMMELIMEEESDEDMLHYSTSPSNKSSQKILKSEDYPSVTPKKMKPG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-