Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.00098 9.8 7.8 0.1 20 52 20 52 13 53 0.83

2 9 0.00014 1.4 10.5 0.4 22 45 50 73 47 82 0.84

3 9 0.11 1.1e+03 1.2 0.2 21 44 79 102 73 105 0.83

4 9 0.025 2.5e+02 3.3 0.3 21 45 107 131 103 138 0.76

5 9 0.0085 85 4.8 0.2 22 45 136 159 131 162 0.87

6 9 0.002 20 6.9 0.0 21 44 163 186 159 194 0.80

7 9 0.0039 39 5.9 0.1 21 44 191 214 188 219 0.79

8 9 5.9e-05 0.59 11.7 0.3 21 45 219 243 214 246 0.90

9 9 0.013 1.3e+02 4.2 0.2 21 48 247 274 242 277 0.78

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.00098	9.8	7.8	0.1	20	52	20	52	13	53	0.83
2	9	0.00014	1.4	10.5	0.4	22	45	50	73	47	82	0.84
3	9	0.11	1.1e+03	1.2	0.2	21	44	79	102	73	105	0.83
4	9	0.025	2.5e+02	3.3	0.3	21	45	107	131	103	138	0.76
5	9	0.0085	85	4.8	0.2	22	45	136	159	131	162	0.87
6	9	0.002	20	6.9	0.0	21	44	163	186	159	194	0.80
7	9	0.0039	39	5.9	0.1	21	44	191	214	188	219	0.79
8	9	5.9e-05	0.59	11.7	0.3	21	45	219	243	214	246	0.90
9	9	0.013	1.3e+02	4.2	0.2	21	48	247	274	242	277	0.78

Coding Sequence: ATGTGCCAGTATGCTGCTTTAACATCGTCCAATCTTAAAGAACATATGCGAAAacatacaggagagaagccATATAAGTGCACTATCTGCGATTATGCTGCTTCAACTTCCTCCAGTCTTAAACAACATATGCCACTACATACAGGGAAGAAGCCCCATAAGTGCACTGTATGTGATTTTGCTACGATACAATCATGTAATCTGAAAAGACATATGCGACAACATTCATATGATTATGAGAAGCCCTATCAATGCAGTTTGTGTGATTATTCTGCTTCAACATCATCCCATCTTAAACAACACATGCCACAACATACAGGGGAGAGGCCCTATAAGTGCACTATGTGTGATTATGCTGGTGCACGTTCGACTTATCTTGAACGACATATGCGACAGCATACAGGACAGAGGCCCTATAAGTGCACTATGTGTGATTATGTTTCTGTACAATCGATATCTCTGAAACATCACATGCAAAAGCATACAGGGGAGAAGCCCAATAAGTGCACCATATGTGATTATGCCTCAGTGGAATTAAGCAATCTTAAACAACATATGCTAACCCATACCGGGGAGAAGCCCTTTAAGTGCACCATCTGTGATTATGCTGCTGCGCGATTGAGTTATCTTGAACGACATATGCGACAACATACAGGGGAGAAACCCTATAAGTGCACTATGTGTGATTATGTTTGTGTGCAATCAACATCTCTTAAACGTCATATACAAAAGCATACAGGGGAGAAGCCCTATAAGTGCGCTATGTGCGAATATGCTGCTGTACAATCGTCCCTCGTTAAAAACCATATGCGACAACAACATACAATATGCAGCAAAGCTGTATGA
Protein Sequence: MCQYAALTSSNLKEHMRKHTGEKPYKCTICDYAASTSSSLKQHMPLHTGKKPHKCTVCDFATIQSCNLKRHMRQHSYDYEKPYQCSLCDYSASTSSHLKQHMPQHTGERPYKCTMCDYAGARSTYLERHMRQHTGQRPYKCTMCDYVSVQSISLKHHMQKHTGEKPNKCTICDYASVELSNLKQHMLTHTGEKPFKCTICDYAAARLSYLERHMRQHTGEKPYKCTMCDYVCVQSTSLKRHIQKHTGEKPYKCAMCEYAAVQSSLVKNHMRQQHTICSKAV

Sequence clustering based on sequence similarity using MMseqs2