Basic Information

Gene Symbol
egg
Assembly
GCA_963966075.1
Location
OZ014514.1:4170271-4225120[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 0.39 4.9e+03 -1.3 0.0 31 43 1528 1540 1493 1544 0.77
2 3 5.2e-13 6.5e-09 36.7 0.0 5 71 1569 1628 1565 1633 0.89
3 3 1.7 2.1e+04 -3.4 0.2 13 27 1895 1909 1894 1915 0.79

Sequence Information

Coding Sequence
ATGTCTGAATCTATGGAAGTTGATTCAGATCCAATTCAGATCGCGAAAAAAAAGAAGACCGACAATACACCATGCGACATAGTGATATTAGATGACGACGATGCCGAGCTAGAGTGCGACTTCATAGATTTGGTCAAAACTGGTTTAACGGCGAATACGAAATGCATAAACTACGCGTGCAAGAGCGGCACGAACATGCTCGAACCACCCGGCTTCTGCTTGTCGTACTATCGCATAAAAAACAAGGTGAAAAAGCGGCAACAAGTTTGTTTGGAATGTTACGAGGAAGCTATAGAGCATTACGATGCATTAGCCGCAGCGGCAAAGAGCGATCGCCCCCTTATGGCAATGCAAGTTGCTTTTCGGAATGACGTTGTTGAAATTGATGATTCGGATTCGGATACTGAGGAAGAAAATGTTGCTGTGGACGTTTCTACTGTTAAATTATTCGAGACCGAGTTTGATAACACGGTTTCCGATGTTTTGCGGAAGTATAATTTCAATGATCAAGTCCGCGAGAGCTGTCAGATCTTGTCGAAAGAGACGGAAGCTATTGCAGATTCTTTTAAGGAGGTGAAAACTATGTTTGAAAGTATACGCTCGGAGTCAGATCAAATGATCTTTGAACTGTCGAATATCATGCGGTCCGATAATATGGAACTACCACCGTTAAATATCATGGACAGGAGGACCCCCGTTAGAAGACAACCATATAAACATACCGCATCTAAAGTTATACCACCAGCAAaaccaGTGGCGTTAAATTCACCGCAGTCTGGCTTGCTGAAGACTGCTTTGCAGAAACCTGGAATATCAAACGTTCCTATTATTGCGTCCCCCGCAAAGGGGGCCACGCCTCCAGTCATTAGGCCAATTGCAGCTGCTAATATGTCGGCCGCTAGTACGTCGGTTGCTTCGACACCAGTCGTTCCGATGCCTCGTGAAGCTAACCCAGACTCTATCGTAGGCCTGACTGGAGATATAGTGATAATTCCGGCAGATTTGCCACCTTTAGGGATAATTGAGAAACCGCCTTTGAAGATCGTTTGTGTTTACATTCCGGAGCGTGCTATGGAGACATGGCGTTTTGTTGAACGTTTTGATTTGGACGACCGTGAAGCTTCCACATTATGCGTTGATGGCTTGCAGCATTTGCAGTCGAGGGGGGTGGACGGCTTATGtagtgtattaaatattttccaTAACAACATCCGAAGTGTGCAAAAGAACTATGATGAGCTATTATTGTTGCTGTCGAGTAGTACAGTTGCATTTCAGGTTATTGTCCTGACGGAGACTTGGTGTATTCGTAATGTTGATAATTTAGGAATTGATGGCTATGACGCTTTTTATAGCGATGGAAAGTTTAACCAGAATGACGGGGTTATGATTTATGTAGATTCAAAGCTGACCTCAGATGTGaatcatatcaaaatacatGAAGTTACGTTTACATGCTTAAAGCTAAATATTGGCGGATTAATAGTTGTTGTAATCGCAGTGTATAGACCACCAGCCACGGACATTGTGTTGTTTCTGGACGATTTGGGCGCCACACTTGATAGTTTGGACCCTGCTGATGTGCATGTGTTTTTGGGggatattaatttaaatattataaattcagGTGACAATTCGGTGCAAGAGTATTTGAGTATATTAAGTGCACACggttttttgtcaaaaattaacACTCCAACACGAGTGTGCAACTCCTCGGAGACCTGTATTGACCACATATTTGTGAGACAGTCTAGAGCGAAAAATGTACAGAGTATCTCAGCTGTTGTGAGAACAGCTTTAACGGACCATTATAGCTCGGTCATCAGATTGTTCGGTGCGGATCCCATGGTAGGAGCTACGAAGAATGATTCCGGCTTAGTGCGAAGCATCTTGCAGTACTCTAAGTTGACCGAAGAGCTTCACGGCGAGAGCTGGCAACAAGTTTATGGTGCACAAAACGCAAGCACTGCCACTGAAGAATTTATTCTGAGATTAACGAGTGCAATAAGTAAGTGTAGTAAAACCAAAAGAACAGGTCAAAGAAGAAATAAAAGGAGAAAACCTTGGATGACAGAAGAACTAGTCAATCTCATTTGTGAGAGAGATACCTTAAAAATAACCGTCGCGATGAATCCTGATAATGAGGCGTACAGGACCGATTACCGGAGTTTTAGAAATCGGGTGACGAGTCAGATACGTAAGACAAGGCAGGATTATTACAGGGCTCAGCTTGATGATGCGGGAACAGATATGAGAAAGATTTGGCAGCTGATTGGTGATGTTACAAATGAGACCAGGTCATCCAACGCAGTGCGACAGATTCGAGATATCGATGGGCAAACTATTACAGATAAAGTAGAGATGTGTGAATTGTTTAATAACTACTATTGTAGTTTGGGACAGAATATGGCGGCCAGTATTGTCGGAGGGATGGTGAACAGCGATGCGTGTGGAGTAGATGCGAGACCTAACAGCCTCTACCTATGTCCAGTAAGCAAATCGGAACTTACCAATATAATATCTTCACTAAGGAATGGGAGTTCTACGGGACAAGATGGTATAAGCTCAATAACATTAAAAGTTGCTCACAACTATCTTCTTGATCCACTGGAACATATAATAAACAACTGTTTTGTCGAGGGAACTTTCCCGAGCATTTTTAAAACAGCCAAAGTGGTCCCAATATATAAAGGCGGACATTTCAGTATGGGTCTTCGGCGTGGTCTTTCAACTGTTGATGCCATGTATGCTCTTGTCCATAATATTTACGAAAGCCTGAATCGTGGGAGGAGGCCAGTggtgatttttattgatttggcAAGAGCTTTCGATACGGTTTCACATGATATACTGATGGAGAAAATGGAAGCGTATGGAATAAGAGGTACTGCGGCGGGCTGGTTTAGAGAATACTTGTCGAAGCGGTCTCAGTATGTTGTGATTGACAATCAGGCCAGCAGCAAACGGGAGATTAATTATGGGGTCCCACAGGGTTCTGTACTCGGCCCAGTGTTATTCCAACTGTATATAAATGATCTTCTCGAATTGGACATAGGTGGCAAAATATATTCATATGCGGATGACACGGCGCTGTTCTTTGATGACGTGGAGTGGACTTTGGTCAAGAAGAAAGCAGAGATCGGTTTGTGCAAAGTACGCAGTTGGCTAACTAAAAATCTGCTGACCCTCAACGCAAAAAAGACAACATTTTTGGCTTTCTCTTTGAATGCTGCAAGCGAGGCAAAATTTGATAAGGTGGTCCTTCATAAATGTGTATATGGGCTCGATTGCTCGTGCACAGAGTCAGTTGGTAGATCGAAGTCTGTCAGATACTTGGGTCTGTATATTGACCAATATTTACGGTGGGACGTCCATGTGCAGTCGGTTGCTGGAAGGGTGCGCAAGTTGCTACATAAGTTCTACCTTCTTAGAGATGTGCTCGGTCGTGCCTTGTTGTTGAGAGTGTATGGGGCTTTGGTTGAGTCAGTAATTACATATGGGATGGTCATTTGGGGGGGTGCGGCTGCAACTATTCTGGAGCCGGTTAATATTGTTCATCGTCACGTGTTGAGAATCTTGGATAGAAGACCGGCTCGCTTCTCGACTAGGGAACTATTCTTGTCTGTTGGGGTTCTGGATATCAGAAGTGATATGTACTACGCAAATCGATCGGAAATGATCGGCTCGTGGATCAAGGTGCAACTGACGGACGTAGTGCTGTCGGGAACGAAAAAAGACGGTCAGATTTTTACGCAAAGCCTCTTTGAGATTTCCATCGAGAATAAACAGAAGGCGGTGCAGAAAAAGTACGTCTCCGGAAAGGAAATTGCGTATTCTACCCTGCCGGGCGTACAGCTGGACGTCGGAACTCGAGTGATTGCGGTTTTTAGAGAAACTACACCAGCGGGagagattaaaaagaacaaaaaggatTCATACTATCCTGGAATTGTGGCGGAACCTTTACAGCCGGCGAATAAATATAGGTACCTAATATTTTTCGACGACGGTTACGCGCAATATGTATCTCATACTAATGTTCACCTCATCTACGAGGCGAACATGAATGTCTGGGAAGACGTAAACGTAAATTCTCGAGCGTTCGTCAAGAAATATCTGGAAAATTACGAGACCAGAGCCATGGTCCGTTTCCTAAAAGATCAAACAGTACGAACCGAGTACaacgggAAATGGTGGGTTACGACGGTTATAAACGTAGATTGTTCCCTGGTCCAAGTATTTTTTGACGATATCAGCAGAATAGAGTGGATCTACCGCGGTTCAACTCGCTTTAGTCCGATGTTCGAACAGGAGCAAGCTGCGGCGAACAGACAACAGAAACAGAGGTTTACAAGGAAGCCaaatATGTCTGGTCCGTACGTAGAATTCACGAGATCTGACGGATCAGCAACAAGTGGGGTTCCCGCCGGCGGCAACTTGGAGACTCAACAgcaacagcagcagcagcaacagCAGAGATCGGTGGCCAGAAAAAGTACTTCGAAACCGCAGGTCGTCAATAATAGTATCACGTCGAATATGAATCCGTTTTTGCCTGCGGACTTAGAAGCACCTGCTACTAAGATTGTGTATTATACCCCGCGCCGACAGAAGCCGAAGACGAACAATTACGAGACACATAACTGCGCCCCAAGTTGCAGGGATTATCTCTACTGCCAGCTAAACAGGATGAAAGGTTACAGTCCGTTGGCCAAACCACTTCTCTGCGGTTTCTACCGTTTGCTATACAAGGTGAAGCATAAGAAGATCGTTGTCTACAGAGCTCCGTGCGGAAGAACATTGAGGAACATGGCCGAGGTCCACAGATATCTGCGGCTTACGAAATCGGACCTTACGGTCGATCTGTTTGACTTTAACGTGTTTGTGAGGTGCCTCGCGGAATTCATGGTTGAGGCGAAGAGTATCATCTTGAAGGATCTCTCAGAGGGTAAGGAAGAATGTCCGATCACCGTCGTCAACTACGTCGACACCAAATCACTGGACTTCTGCAACTATTCAACAAGGAGGCAACCCATGGAAGGTGTCATGCTGAACCTAGAGTCCGATTTCCTCGTCGGATGCGATTGTACCGACGATTGCTCGGACCGAAGCAAATGTTCATGTTGGCAGCTAACACTCGAATCTCTCAAGTACATGGACAAAGATACAGACCCTGAATCAGTGGGATATCAATACCGTAGACTCCCCGAACCTATATTCTCCGGGATATTTGAGTGCAATCAGCGGTGTAAATGTGCCGCAACTTGTCTCAATCGTGTCGTTCAGAATCCGATGCAGCACAAGCTTCAGGTGTTCAAGACTGATTCCCGAGGATGGGGGATCCGCTGCCTCAACGATATTCCGCAGGGCTCCTTCATCTGTATATACGCCGGCAGCCTGTTAACCGAGGATATCGCAAATATGGACGGCAAATCGTACGGCGACGAATACCTAGCGGAATTGGACTTTATCGAAACCGCGGAACGCGCCAAGGAAGATTACGAGGACGACCCTTACCACGAGGAACTAGCGAAGGACGAAAAAACTCCCGAACCAAGCGAAGAGGAGGACGCCGCCGAAGAGGACGACAACGACCTGGATAGCACGCGGGATCGCCAGGAAGATTTCGATTTCGTCCCGAGCATGTTCATCCCGAAAGATACTCAGCAGAAGGAAGAGACAGGTTATCGATCGCGACTCAGGCAGAGGAAGAGCAGCGCTAAACAATTGCAAGAGAAAAAGGCAGACAAGGCTGAAAAGGCAGAGAAAGCGGAGAAAGCTGAAAAAGTGGAGAAGGCCAAGGCAAAGCCTCCGCCGCCTGTTGTCGAAGATGATGATACGGTTATGATTAGCGACGATGAAGATTATGTTCCCAGAGAACCCAGTAGTTTTATACCGAAAGATGAACCTGCCGATGAGGATCGGAGAAAGTACAGCTCAGTACGAGAGATGTTTGGATCAGAAGAAGACGTATACATCATGGACGCAAAGAGCACAGGAAATATTGGAAGATTTTTGAACCATTCATGTTCACCAAATATTTTCGTCCAGAACGTCTTTGTGGACACCCATGACCCCCGTTTTCCGTGGGTGGCGTTTTTCACGATGAGTTACGTAAGGGCGGGAACGGAGCTCACTTGGAACTACAATTACGACATCGGAAGTGTGCCAGATAAGGTTTTGTACTGTTACTGCGGTTCCAGTGAGTGCAAAGGTCGTCTTTTGTAA
Protein Sequence
MSESMEVDSDPIQIAKKKKTDNTPCDIVILDDDDAELECDFIDLVKTGLTANTKCINYACKSGTNMLEPPGFCLSYYRIKNKVKKRQQVCLECYEEAIEHYDALAAAAKSDRPLMAMQVAFRNDVVEIDDSDSDTEEENVAVDVSTVKLFETEFDNTVSDVLRKYNFNDQVRESCQILSKETEAIADSFKEVKTMFESIRSESDQMIFELSNIMRSDNMELPPLNIMDRRTPVRRQPYKHTASKVIPPAKPVALNSPQSGLLKTALQKPGISNVPIIASPAKGATPPVIRPIAAANMSAASTSVASTPVVPMPREANPDSIVGLTGDIVIIPADLPPLGIIEKPPLKIVCVYIPERAMETWRFVERFDLDDREASTLCVDGLQHLQSRGVDGLCSVLNIFHNNIRSVQKNYDELLLLLSSSTVAFQVIVLTETWCIRNVDNLGIDGYDAFYSDGKFNQNDGVMIYVDSKLTSDVNHIKIHEVTFTCLKLNIGGLIVVVIAVYRPPATDIVLFLDDLGATLDSLDPADVHVFLGDINLNIINSGDNSVQEYLSILSAHGFLSKINTPTRVCNSSETCIDHIFVRQSRAKNVQSISAVVRTALTDHYSSVIRLFGADPMVGATKNDSGLVRSILQYSKLTEELHGESWQQVYGAQNASTATEEFILRLTSAISKCSKTKRTGQRRNKRRKPWMTEELVNLICERDTLKITVAMNPDNEAYRTDYRSFRNRVTSQIRKTRQDYYRAQLDDAGTDMRKIWQLIGDVTNETRSSNAVRQIRDIDGQTITDKVEMCELFNNYYCSLGQNMAASIVGGMVNSDACGVDARPNSLYLCPVSKSELTNIISSLRNGSSTGQDGISSITLKVAHNYLLDPLEHIINNCFVEGTFPSIFKTAKVVPIYKGGHFSMGLRRGLSTVDAMYALVHNIYESLNRGRRPVVIFIDLARAFDTVSHDILMEKMEAYGIRGTAAGWFREYLSKRSQYVVIDNQASSKREINYGVPQGSVLGPVLFQLYINDLLELDIGGKIYSYADDTALFFDDVEWTLVKKKAEIGLCKVRSWLTKNLLTLNAKKTTFLAFSLNAASEAKFDKVVLHKCVYGLDCSCTESVGRSKSVRYLGLYIDQYLRWDVHVQSVAGRVRKLLHKFYLLRDVLGRALLLRVYGALVESVITYGMVIWGGAAATILEPVNIVHRHVLRILDRRPARFSTRELFLSVGVLDIRSDMYYANRSEMIGSWIKVQLTDVVLSGTKKDGQIFTQSLFEISIENKQKAVQKKYVSGKEIAYSTLPGVQLDVGTRVIAVFRETTPAGEIKKNKKDSYYPGIVAEPLQPANKYRYLIFFDDGYAQYVSHTNVHLIYEANMNVWEDVNVNSRAFVKKYLENYETRAMVRFLKDQTVRTEYNGKWWVTTVINVDCSLVQVFFDDISRIEWIYRGSTRFSPMFEQEQAAANRQQKQRFTRKPNMSGPYVEFTRSDGSATSGVPAGGNLETQQQQQQQQQQRSVARKSTSKPQVVNNSITSNMNPFLPADLEAPATKIVYYTPRRQKPKTNNYETHNCAPSCRDYLYCQLNRMKGYSPLAKPLLCGFYRLLYKVKHKKIVVYRAPCGRTLRNMAEVHRYLRLTKSDLTVDLFDFNVFVRCLAEFMVEAKSIILKDLSEGKEECPITVVNYVDTKSLDFCNYSTRRQPMEGVMLNLESDFLVGCDCTDDCSDRSKCSCWQLTLESLKYMDKDTDPESVGYQYRRLPEPIFSGIFECNQRCKCAATCLNRVVQNPMQHKLQVFKTDSRGWGIRCLNDIPQGSFICIYAGSLLTEDIANMDGKSYGDEYLAELDFIETAERAKEDYEDDPYHEELAKDEKTPEPSEEEDAAEEDDNDLDSTRDRQEDFDFVPSMFIPKDTQQKEETGYRSRLRQRKSSAKQLQEKKADKAEKAEKAEKAEKVEKAKAKPPPPVVEDDDTVMISDDEDYVPREPSSFIPKDEPADEDRRKYSSVREMFGSEEDVYIMDAKSTGNIGRFLNHSCSPNIFVQNVFVDTHDPRFPWVAFFTMSYVRAGTELTWNYNYDIGSVPDKVLYCYCGSSECKGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-