Basic Information

Transcription Factor Domain

TF Family: zf-LITAF-like
Domain: zf-LITAF-like domain
PFAM: PF10601
TF Group: Zinc-Coordinating Group
Description: Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 4.7e-07 0.0015 19.4 1.2 2 32 89 119 88 121 0.92

2 2 1e-23 3.3e-20 72.8 12.2 2 69 189 256 188 257 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	4.7e-07	0.0015	19.4	1.2	2	32	89	119	88	121	0.92
2	2	1e-23	3.3e-20	72.8	12.2	2	69	189	256	188	257	0.93

Coding Sequence: ATGGACACAGAAAACAGCAAAAGCAGGGCGCAACCTCCACCATATACTGTTGAATTAGCTGGGCAGACAACAGCTCCAGGTCCAAGTACACACTTCAATCCACCGTACCCACAACAAAATGTATTTCCTGGAACCCACCCAGAAGGTACACACATCGATCCACCATACCAACCACCAAATGTATTTCCTGGATCACACCCAGTAACTGTACAACCAGGACCATCGGTTCACGTCGTGGTCGATGTTCCCTCGCAATTCGGTACCAAAAGCCAGTTTGTTAGATGCCAGAACTGTGGTGCCCAAACTTTCACAAAAACGGAATCGAAAGTGACAGCGACGACACACATAATTGCTGTGATGGATACAGAAAACACCAAACAGAGGGCGCCACCGCCACCATACACGGCTGAAGCATTACCTGAGCACTCAGCGGCCCCAGGTCCAAGTACACACTTCAATCCACCGTATCCACAACCAAATGTATTTCCTGGATCGCAACCAATTACTGTACAACCTGCAGCTACAAtgCACATCGTCCAGAATGTTCCCATGCAATTTGGCACCAAAAGCCAGTTTGTTAGATGCCAGAATTGTGGTGCTGAAACTATGACAAAAACCGAATCAAAACCCACAACGACTACACACTTGATCGCAATGGTATTGTGCTGCTTGATCTTATGGCCAATTGCATGGCTTCCATATGTTTGCAAGTCCTGCCAGAGCACACACCATTATTGTTCAAACTGCAATCAGTTCTTAGGCGAACGGCACGTTTAG
Protein Sequence: MDTENSKSRAQPPPYTVELAGQTTAPGPSTHFNPPYPQQNVFPGTHPEGTHIDPPYQPPNVFPGSHPVTVQPGPSVHVVVDVPSQFGTKSQFVRCQNCGAQTFTKTESKVTATTHIIAVMDTENTKQRAPPPPYTAEALPEHSAAPGPSTHFNPPYPQPNVFPGSQPITVQPAATMHIVQNVPMQFGTKSQFVRCQNCGAETMTKTESKPTTTTHLIAMVLCCLILWPIAWLPYVCKSCQSTHHYCSNCNQFLGERHV

Sequence clustering based on sequence similarity using MMseqs2