Basic Information

Insect: Aphaenogaster picea
Gene Symbol: topi
Assembly: GCA_003063865.1
Location: NJRM01000451.1:11675-13999[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 16 0.0011 0.12 13.3 2.6 1 23 243 265 243 265 0.97

2 16 0.12 13 6.9 1.1 2 23 272 294 271 294 0.95

3 16 0.0033 0.37 11.8 0.2 2 21 301 320 300 321 0.92

4 16 0.0013 0.14 13.1 1.0 1 23 328 350 328 350 0.96

5 16 1e-06 0.00012 22.8 2.2 1 23 356 378 356 378 0.98

6 16 0.12 14 6.9 0.3 2 23 390 412 389 412 0.90

7 16 0.0013 0.15 13.0 5.6 1 23 428 450 428 450 0.97

8 16 3.6 4e+02 2.2 0.2 1 23 456 478 456 478 0.90

9 16 0.17 19 6.4 1.0 1 23 488 511 488 511 0.93

10 16 0.064 7.2 7.7 0.0 1 21 525 545 525 546 0.91

11 16 0.0046 0.52 11.3 0.1 1 23 551 573 551 573 0.98

12 16 2.1e-06 0.00023 21.9 3.1 1 23 579 601 579 601 0.98

13 16 0.00013 0.015 16.2 0.3 1 23 607 630 607 630 0.97

14 16 0.05 5.6 8.1 0.7 1 23 636 658 636 658 0.89

15 16 3.3e-07 3.7e-05 24.4 2.2 1 23 664 686 664 686 0.99

16 16 1.8e-05 0.0021 18.9 6.4 1 23 692 715 692 715 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	16	0.0011	0.12	13.3	2.6	1	23	243	265	243	265	0.97
2	16	0.12	13	6.9	1.1	2	23	272	294	271	294	0.95
3	16	0.0033	0.37	11.8	0.2	2	21	301	320	300	321	0.92
4	16	0.0013	0.14	13.1	1.0	1	23	328	350	328	350	0.96
5	16	1e-06	0.00012	22.8	2.2	1	23	356	378	356	378	0.98
6	16	0.12	14	6.9	0.3	2	23	390	412	389	412	0.90
7	16	0.0013	0.15	13.0	5.6	1	23	428	450	428	450	0.97
8	16	3.6	4e+02	2.2	0.2	1	23	456	478	456	478	0.90
9	16	0.17	19	6.4	1.0	1	23	488	511	488	511	0.93
10	16	0.064	7.2	7.7	0.0	1	21	525	545	525	546	0.91
11	16	0.0046	0.52	11.3	0.1	1	23	551	573	551	573	0.98
12	16	2.1e-06	0.00023	21.9	3.1	1	23	579	601	579	601	0.98
13	16	0.00013	0.015	16.2	0.3	1	23	607	630	607	630	0.97
14	16	0.05	5.6	8.1	0.7	1	23	636	658	636	658	0.89
15	16	3.3e-07	3.7e-05	24.4	2.2	1	23	664	686	664	686	0.99
16	16	1.8e-05	0.0021	18.9	6.4	1	23	692	715	692	715	0.97

Sequence Information

Coding Sequence: ATGTTACAGGCAGAGTCAATTAGTACACTAAGTGACCATGAAGATGATATTGATGATTTGGATGGTTCTACAATATGTTCCCAAGAGGAACCACTTTCTTCCAACGAAATATTGGAATTATCGGCGCaagatgaaaaagaaaacaGTTTATCTGCTTTTTGTCGATTGTGTGCTGGTCAAACTGCTAATCCAATATATATCTATTCTGAATTCGGAGAATCAATGAAATTGGCACGGAAAATAAATACATGTCTAAGCATTaagATTAAGAAGACAGACCCATTACCGAAGCAGCTTTGTTTGACCTGCGTTGAGAAAGTGAACTGGTGTGACAAATTTGACACACAGTGCATTAAAGCAGAGGAAACCCTGTCAGTGATGCTAAAAGAGAAGCAACCTTTTAATATTTCCAATCGATTCTTTTCTGATCAACAATCCTGTCCCTTATGCATAAAAGGCTTCATGAATACGTGCGAAGAGACATTCCAGAATACGAAGGATATGGAATTATACGAGAATAACATAATTCTAGAAAGCAGTGACGAggaaaacatatttaataacgCGAAGGTGAATAAGGAGAGCGGGAATCGTTCTATCACATTACAATGCTTGGGGACTGGGCAGCAATATCTAAAATGTGGAGCGTGCATGAACCTTTATCACACCGAGGAGACATTAGACGGTCACAAGTGTAAACCCAGTATACAGAACACAACAAAGCCGTACAAGTGTCTCATATGTGACAAGACATTTACCTTCGAGGAACGATTGAACTTTCACATGCGATTTCACAAAGGCGCGAAAGCATTATACTGCGAGGTCTGTAAGATAACGTTCGGTAAAGAGCTGAAACTGTTCTACCACTATAAGAGACAACATTCTAAGGATATTAGCGTCTCATGTCTGCAATGTGGAAAGTTATTCGAGAATCAAGAGGCACTCCGAGTGCACGTTTGCGTCGACGGTAAAAATCGGCCTCACATTTGCGAGGTGTGCAGCAAAGGCTTTTTCGACGGCTACACCCTGAAGCGTCACGTAGTGACGCACCTGCCCGAGAAGCCTTACAAGTGCTCGGAGTGCTCGAAGAGTTTTACACAGAAGTCGAGATTGAACAAACACGTCGCGAGCCACTGCATAGTTATCGAGAATAGCCAGACGGTCTGGAAATGCATCCAGTGCGGTGAAGTGTTCACCTCTTGCGACGACGCAGATATTCATTACAAGATAATGCACGAGGACAAGGTCACGCTAATCGAGGAGCTACCGACATCAAAGCTGTATCATTGTGAATTTTGCAACAGCCATTTTACCAACGCGGACAATCTGAAGACTCATCAAAGCCAGCATGTCGTCGAAAGACCCTACACGTGTAATACATGCATGGCCACTTACAAATCGTTCGCGGAAGCTGTTTTACATTGGAAGGAACATCCCAGACTGTTCAAGGTTCTCGTCGTCTTCCTATGCGACGTCTGCAACAAGGACATGAAGGAATTATCCCTGCTATACAAGCACAGGCAAAACAGGCACGACCGTGCATCCAGATCATCCGAATCGGGCGACGCGAAGTTCATCTGCGAACTCTGCGGGAATGTGTTCGACAAAAGCGAGGATATACAGGATCACGGACGGGATCAATGTTCCAAGTTTCCCTGCGACATTTGCGGCAGTCTGCTGCCCACGGCGAACTCGTTAAACGCCCACAAAAGGCGGCACAACGGTTTGAGGCCGTACGTCTGTAACATTTGCGGAAAGAGTTACACCCAGTCCAGTCACATGTGGACCCACAAGAGATTCCATATGGGCATCAAACCTTACGCGTGCGAATATTGTGATCAGCGATTCACGATAAAGCCGGACCTGGCGGATCACGTTAGGAAGAAGCATACGAGGGAGAGACCGTTCAAGTGCGACGTGTGCAATAAGGCTTTCCTGACCGGGTCCGTGTTCTACCAGCACAGATTAATACACCGTGGCGATCGCAGGTACAAGTGCCATTACTGCGAGAAGGCCTTCACCAGGACGGAGGCTTTGAACAATCACATCAAAATACACACCGGGGAGAAGCCGCACTCGTGCGACGTATGTGGTAGATGCTTCAGGCAGAAAGGAGACATGAGGAAGCACAAACGCACCAAGCACGCTTCCGAGCAAAACAAATCTTGA
Protein Sequence: MLQAESISTLSDHEDDIDDLDGSTICSQEEPLSSNEILELSAQDEKENSLSAFCRLCAGQTANPIYIYSEFGESMKLARKINTCLSIKIKKTDPLPKQLCLTCVEKVNWCDKFDTQCIKAEETLSVMLKEKQPFNISNRFFSDQQSCPLCIKGFMNTCEETFQNTKDMELYENNIILESSDEENIFNNAKVNKESGNRSITLQCLGTGQQYLKCGACMNLYHTEETLDGHKCKPSIQNTTKPYKCLICDKTFTFEERLNFHMRFHKGAKALYCEVCKITFGKELKLFYHYKRQHSKDISVSCLQCGKLFENQEALRVHVCVDGKNRPHICEVCSKGFFDGYTLKRHVVTHLPEKPYKCSECSKSFTQKSRLNKHVASHCIVIENSQTVWKCIQCGEVFTSCDDADIHYKIMHEDKVTLIEELPTSKLYHCEFCNSHFTNADNLKTHQSQHVVERPYTCNTCMATYKSFAEAVLHWKEHPRLFKVLVVFLCDVCNKDMKELSLLYKHRQNRHDRASRSSESGDAKFICELCGNVFDKSEDIQDHGRDQCSKFPCDICGSLLPTANSLNAHKRRHNGLRPYVCNICGKSYTQSSHMWTHKRFHMGIKPYACEYCDQRFTIKPDLADHVRKKHTRERPFKCDVCNKAFLTGSVFYQHRLIHRGDRRYKCHYCEKAFTRTEALNNHIKIHTGEKPHSCDVCGRCFRQKGDMRKHKRTKHASEQNKS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01354793;
90% Identity: iTF_00765849;
80% Identity: iTF_00126925;