Basic Information

Gene Symbol
-
Assembly
GCA_945859755.1
Location
CAMAOQ010000031.1:1281903-1313661[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 0.022 24 5.7 0.0 18 68 372 422 366 459 0.87
2 3 0.0014 1.5 9.5 0.0 17 85 484 552 471 567 0.82
3 3 9.7e-05 0.11 13.3 0.0 12 85 972 1045 962 1060 0.82

Sequence Information

Coding Sequence
ATGAGGTGCTGTGTAGAGACCTGCTTCAATGATGATTcgaagaaaacaaataaaatcctTGGATTAACATTTCATAAGTTACCGAGGGATCCAGACCATTCTGCGGCATGGTTAGCAGCTTTAGCTGTACTGGGTGGTCGAATGAATAAGTGTCTTGTAGTATGCTCTGAACATTTTCTACCTGAAGACTTTGATAATACACGGCATAATCAGCGAAGGGTCAAAAGTGGAGCCGTTCCTACCATAGCAACAGTGTGCAGAGTATGCCTGGCTTCAGATGTCAAAATGTACAATATGAAGGATTTTAGACTGGGtgaaatgtttcaaaatatcACAGGAATATCGGCTATCGACAAAAAAGGCAGTCTACAACAGAGGGTTTGTTGGGAGTGCGCTGCGCGCCTCACAGCAGCTGCAGCATTCAGAGAAAAAGCGCTGCTCACCGAAACATTGCTGAAAAACCAAGTACACATCAAAGAAAGTGACATtgcattattaaaacaaaattacaattcTTTAAAATCACCTCTATCCGTTAAAACAGCGGTTACTTCATATGATATTGAATGCGAACATACTATATctgaaaataaagaagtaaaaataATACGAAATGATGAGACAGATATCCAAGACAGAAAACTTGGAATAAGAGTTGTtattgaagaagaaaaagagATAGGATACGACCAGTACGAGTCTTGGATAGATGTTCCTGTAAAAACTGAAATAGAAACTGATCCCATAGCTGATAATAATGTGCGATTTCAAGATCGAAAAGGCGATACTTTCTCAGAACAAACACATTTCAATGATACACCTTCCAGCGAAGATAGTGAAGGTGAATTGACAATTGATACCGAAGGACAAATGCATAATAATGATAGTATTATAAGAGAAGATATCCCAAAACAAATCCCGTACATAAATGACGCTGGTAACATCATTTTAGTTGATAAAGAGAAAAAATTGAAGCCTGGTGTATTCGGTAATACTGTGGACGAGTGCTCGAGTGATGAAGAAGTACCAAGTACAGCAGTATCTGGCAATACGTCTAAAGAAACGATGAGCAGTGAGGAGGCTTCGAATAAAAGAGTAAGGCGTAGGTACATGCTTAACGAcaggataaaagaaaaaataattgcgTTGAAGAGTAGCGGTCTCCCAGTTTCCGCAATATCTAAAGAAACTGGATTGTCGacATCATCTATAAACTGTTGGTGGAGACGCTACCGAATGAGCGGTAACACATACCGTAGATCTATTACTCCAGGATTCCAGACTATCTCAAAACAGAATTACTTTTACAACGCTGCAGAACCTGGCAAGGAGATGGAGCCTTGTCCTACAATAGTGAGGCAGAGATTGTGTGAAGCTGGCCTTGAACACATACTCATGAAGAAGCCTGAAAGAACTGTGAATACGGGGGTGAAAACTAGtacGCGTCAAGCGCTCCACGAGGATTTAAAACAGCGAATAATAGCGCTGAAGCAGGAAGGAATGTCCAATAGCCGGATAGCTTACCTGTTAAATACTGCACGAAACACAGTTCAAAAGTGGTGGACTCGCTGGTGCAATGAAGGGCATATGCAAAACCTCAAACAGCCCGGAAGGAAAAGAAAAACTACGCCTCAAGAAGACCAACTCTTAATAGAACGGGTGACTCAGGAACAAACAGTGCATACACCCACCCTGGCTAAGGAATTTGGCATTTCTTTGAAGTTACCGAGGGATCCGGACCATTCTGCAGCATGGTTAACAGCCTTAACTGAACTGGGGTACCAAATGAATAAGTGTCTTGTAGTATGCTCTGAACATTTTCTACCTGAAGACTTTGATGACACTCGACCCAATCAGCGAAGAGTCAAAAGTGGAGCAGTTCCTACCATAGTTATCAACAAAAAAGGCAGTCTACTACAGCGGGTTTGTTGGGAGTGCGCTGCGCGCCTTACAGCGGCTGCAGCATTCAGAGAAAAAGCGCTGCTCACCGATGCATTGCTGAAAAACCAAGTACACATCAAAGAAAGTGACATTGCAttactaaaacaaaattacagttATCTAAAATCACCTCTATCTTGTATAACAGCAGTTGCTTCACATAATATTGAATGCGAACATACTATCTCTGAAAATGAAATAGACGACATATTTATACCCAGTGATAATACAGCTATACAGGAGAAAAAATCTGAAATAAGAATAAATGAGAAAGGTATAGAATTTGATGAGGGAGAGCCTTGGATAGATGTTCCTGTAAAAACTGAGGTCGAAACTGACCCTATAGCTTATAATAACATGCGATTTCAAGATCAAAAAAGCGTTCAACTTTTCGAACATTCCAATGATACATCTCCCAGAAAAGACAATGAAGATGAAACGAGGAATACTGAagcacaaattaataataatgataatattttaagagaaaatAAAGTCGCGGTCTTAAGTGATATCAACATCGCTTTCGTAGAACACAATGATGATGTAGATAAGAAACCACAGCTTGATGTTTTCGGTAATATTGTGTATGATGATTCAAGTGAAGACAACAGACATTCAGAAGAAGTATCTTTCAAGAAGTATAAGCAAAATATGAGCAGCAAGGTTGGGATTAAGAAGGAAAGAACACATACTAAGATCAACGACTgtttaaaggaaaaaataattgCATTGAAGAAAATGGGTCATTCTGTTCCCGCTATAGCTCAAGAAACTGGAGCGTCGataacTTCCATTTACAGGTTACTTCGCTATAACCTTGATTCAGAACAGAATGACTATCATAACGCTGAAGCGGGTAAAGAAATAGCGGCTTGTTCTGCGACAGTCAGGCTACGAATGCGGCAAGCTGGCCTTGAACACATACTCATGAAGAAGCCTGAAATAGTAAATATGAATATGGGGCAGAATGTAAGCAAGAATAAAGCGCTTCATGACCATTTAAAACAGCGAATAATAGCGCTGAAGCAAAAAGGAATGACTAATCACCGGATAGCTTACCTGTTGGATACTACACGACATACGGTTCGCAAATGGTGGAATCGCTGGTGCAATGAGGGCCATATGAACAACTATAAAAGTACGGGAAACAAGAGGAAGACGACGCCTCAGGAAGACCAGCTCTTAATAGAGCGGGTTGCTCAAGAGCAAACTGTTCACACGCCATCCCTGGCTAAGGAACTAGGCGTTTCTGTAAagtaa
Protein Sequence
MRCCVETCFNDDSKKTNKILGLTFHKLPRDPDHSAAWLAALAVLGGRMNKCLVVCSEHFLPEDFDNTRHNQRRVKSGAVPTIATVCRVCLASDVKMYNMKDFRLGEMFQNITGISAIDKKGSLQQRVCWECAARLTAAAAFREKALLTETLLKNQVHIKESDIALLKQNYNSLKSPLSVKTAVTSYDIECEHTISENKEVKIIRNDETDIQDRKLGIRVVIEEEKEIGYDQYESWIDVPVKTEIETDPIADNNVRFQDRKGDTFSEQTHFNDTPSSEDSEGELTIDTEGQMHNNDSIIREDIPKQIPYINDAGNIILVDKEKKLKPGVFGNTVDECSSDEEVPSTAVSGNTSKETMSSEEASNKRVRRRYMLNDRIKEKIIALKSSGLPVSAISKETGLSTSSINCWWRRYRMSGNTYRRSITPGFQTISKQNYFYNAAEPGKEMEPCPTIVRQRLCEAGLEHILMKKPERTVNTGVKTSTRQALHEDLKQRIIALKQEGMSNSRIAYLLNTARNTVQKWWTRWCNEGHMQNLKQPGRKRKTTPQEDQLLIERVTQEQTVHTPTLAKEFGISLKLPRDPDHSAAWLTALTELGYQMNKCLVVCSEHFLPEDFDDTRPNQRRVKSGAVPTIVINKKGSLLQRVCWECAARLTAAAAFREKALLTDALLKNQVHIKESDIALLKQNYSYLKSPLSCITAVASHNIECEHTISENEIDDIFIPSDNTAIQEKKSEIRINEKGIEFDEGEPWIDVPVKTEVETDPIAYNNMRFQDQKSVQLFEHSNDTSPRKDNEDETRNTEAQINNNDNILRENKVAVLSDINIAFVEHNDDVDKKPQLDVFGNIVYDDSSEDNRHSEEVSFKKYKQNMSSKVGIKKERTHTKINDCLKEKIIALKKMGHSVPAIAQETGASITSIYRLLRYNLDSEQNDYHNAEAGKEIAACSATVRLRMRQAGLEHILMKKPEIVNMNMGQNVSKNKALHDHLKQRIIALKQKGMTNHRIAYLLDTTRHTVRKWWNRWCNEGHMNNYKSTGNKRKTTPQEDQLLIERVAQEQTVHTPSLAKELGVSVK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00124335;
90% Identity
iTF_00124335;
80% Identity
iTF_00124335;