Basic Information

Gene Symbol
Zfa
Assembly
None
Location
AY:34324-63442[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.074 3.5 8.0 4.6 1 23 261 283 261 283 0.98
2 11 0.38 18 5.8 1.3 1 23 290 312 290 312 0.95
3 11 0.038 1.8 8.9 0.4 1 23 316 339 316 339 0.94
4 11 3.6e-06 0.00017 21.6 1.6 1 20 346 365 346 369 0.96
5 11 9.6e-05 0.0045 17.1 2.8 2 23 376 398 375 398 0.97
6 11 0.0017 0.082 13.1 2.1 2 23 412 433 411 433 0.96
7 11 3.2e-05 0.0015 18.6 0.7 1 22 439 460 439 464 0.94
8 11 9.9e-05 0.0047 17.0 2.1 2 23 473 495 472 495 0.95
9 11 0.00013 0.006 16.7 0.4 1 23 501 524 501 524 0.97
10 11 9.5e-06 0.00045 20.3 2.0 1 23 533 555 533 555 0.99
11 11 0.0003 0.014 15.5 0.1 1 23 561 584 561 584 0.96

Sequence Information

Coding Sequence
ATGGAGAACGTTGTGGATATTACTAAAATATGCTACGGATGTTTAAAAAATGAAAATGAAAGTAAATTGTGCAAATTTATTGTTGAAGATGGACCTCTACAGAGCGTTTTCCAGGTTAATATGATTAATCTATGCTACTTGTGTAAGAGATCAGCAGAGAAAGTATCAACATTCATTCAAAATGTTCAGAGTAATCAATTGTTGTTGGAAAATATTCATGTTCTTATGGATTCAACATTCCAAACAATGAAGGCTCAAGTCAACCCACTGTCAAATCTCAACCAAGTTACATTAGACTATATAGAGTTGTTGGATGCTGGTAATGATTCTGTTGAATCATTTACTGTATTTGGGATAGGATATAAAGAAACAAGAATTAAGACTGAAATGAAGGAGGAATATGCGGAACACCTGGATCAAACGGACAAGGAATTTAGCAATGATGAAGACGAATATCCTGATAAATATCTCAAAGAGGAGGATAGGTTTCCGTTAGCCGAACTACTGGAAACAGATGTGAAAGTAAAGGATATTGGCCTGATGAGCCTTAAGGATTTACTGAAGCAAAGTAAACCAATAGCAAAAGCTCTGAATGAGGATTTGGGACAAACGAATAATACTGAGTTACATGAGGATTCATATGTTAAAGATTTCCAAAGGGCCTGTGAAACGACTGACGTCCTTGAGGAACCACAGATAGAAAAAATCTTTTTAACGACCAAGCAGTGTATGGAGGAACGTGATAAACTAATACTGGACCAGAAGTACCAAGAGTTCACGTTTAAATGTAGATATTGCATCAAAGGATTTGAAAACAAACTATGCTACGAAAGACATATGGATAAACACAGTGAGGGCGCCGGTAACTTTATTTGTGAGATCTGTAACATGAGAAAAGACACGTCGTTCAAATTGGCACGACATCGGAGTTATCATATTATACGATATAAATGTACAGAATGCGGTTTAATAAGAAACAATAGGGCCACTATAAAAGAGCATTATAATGCTTATCATGCACACGGGTACCATCAGTATAACTGTCCGCATTGCCCTAAGAATTTCAAGCGTCAAGTGTCATTGAAGAAGCATATATGGTACGCGCATAAGACGAAGGGCAAAGTGACGTGCGCGTACTGTCACAAGACTTACGCTCACAAGGAAGTGCTCAAAGTTCACATGATGACAAGACATGCGGAGAATGTATCGGCGGTTGAGAAACCGAAGCGATGGGTCTGTCAGGAGTGCGGTGCCGGGTTCAAATGCCCATCGCATCTGAAAAAGCACAGCCTCACGCATATACACAGCAAGGACTTCTACTGCGTCGAATGTGATAAAAATTTCAAATCGGATTCAACGTTAAAACAGCACCTAAAGACTGCTCTAGCTCACGTGAACTATGTCCAATTACCACTTTCTTGCGAACACTGTAACAAACGTTTCGCTATCAAAAGAGACCTCGAGAGGCACACGAACAGGATACATTTGAACGTGAAGCCGTTTCAGTGCGACCGCTGTGAAAAGGCTTATGTGAACTCTTGGTCTCTGACAGAACATAAACGTCTAATACATGAAGGTTATAAGAGGCCGCTGAAATACCCGTGTCCGATGTGCGATAAAGCGTTCCATCGTAACCACATTCTAAAGGCCCATATAAGAACCCATACTGGTGAAAGACCATATCAGTGCACCAAATGCCCAGCCCAGTTCAGCCAAGCGAGTGTTCTGGCGACCCACGTGAAGTTGATACACTTAAAGCTGACCAGAGATGGAAGACCCAAGGCTTTGGCTATAAAATAA
Protein Sequence
MENVVDITKICYGCLKNENESKLCKFIVEDGPLQSVFQVNMINLCYLCKRSAEKVSTFIQNVQSNQLLLENIHVLMDSTFQTMKAQVNPLSNLNQVTLDYIELLDAGNDSVESFTVFGIGYKETRIKTEMKEEYAEHLDQTDKEFSNDEDEYPDKYLKEEDRFPLAELLETDVKVKDIGLMSLKDLLKQSKPIAKALNEDLGQTNNTELHEDSYVKDFQRACETTDVLEEPQIEKIFLTTKQCMEERDKLILDQKYQEFTFKCRYCIKGFENKLCYERHMDKHSEGAGNFICEICNMRKDTSFKLARHRSYHIIRYKCTECGLIRNNRATIKEHYNAYHAHGYHQYNCPHCPKNFKRQVSLKKHIWYAHKTKGKVTCAYCHKTYAHKEVLKVHMMTRHAENVSAVEKPKRWVCQECGAGFKCPSHLKKHSLTHIHSKDFYCVECDKNFKSDSTLKQHLKTALAHVNYVQLPLSCEHCNKRFAIKRDLERHTNRIHLNVKPFQCDRCEKAYVNSWSLTEHKRLIHEGYKRPLKYPCPMCDKAFHRNHILKAHIRTHTGERPYQCTKCPAQFSQASVLATHVKLIHLKLTRDGRPKALAIK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01317568;
90% Identity
iTF_00113536;
80% Identity
-