Basic Information

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 7.9 8.2e+03 -2.8 0.0 35 54 50 69 42 85 0.67

2 3 1.7e-16 1.8e-13 50.6 1.0 1 48 160 205 160 207 0.94

3 3 0.095 99 3.4 0.0 69 84 205 220 202 224 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	7.9	8.2e+03	-2.8	0.0	35	54	50	69	42	85	0.67
2	3	1.7e-16	1.8e-13	50.6	1.0	1	48	160	205	160	207	0.94
3	3	0.095	99	3.4	0.0	69	84	205	220	202	224	0.81

Coding Sequence: ATGCATATTACATCGGGGCTGTCACCAGTGTCCGGCGAGATGCTGGACACATCAGCGTTGAACTTCTACGGGGATGCGGGCGATTGTGGGGCAACGTACTTCGCAATCGACCACGCAGTCCCTGAATCCTCCCATACTGTTGAAATCGAGTATGTCTATGAACAACCAGAAAGCCACACCGAGTATCAAAATGACATAGACATTGATATATCAGAAACCGGCACCCTAATAGAAGTAGAAGTAACAGCTCAGGCAAAAGACGATCACGTTGAAGACGAACAAGACTTGACGAACCTAACGTGGCTGCAAAATATAACAAACATAATGTCAGTACCGGAGTTCCCACTCGCGCCGATGTCACCAAATCCACAAAAAGTCTCGCCGCAGAACACGAGGCTTCAGAAATTCAACCAGACGATAGCGAAATGCCAGAACGATTTCATGGAGAACAAAGGGGAATACCAGACGAACAGCGAGAAGAAACCTCCTTACTCATACAGCACTCTCATTTGTATGGCTATGAGATATAACAATGATAAAATGACGCTATCTGCGATATATTCATGGATAAGGGAGAACTTCAAATACTACAGGAAGGCGGACCCCACTTGGCAGGAGCCGGGGAAGGGAGGGTTTTGGAAACTGGACTTGGCTCACTTAGAAGGCACCAAACGTATATCAAATAGACCACACAAGAAAAAGAAGAACTCTTCTGAAACAAAACAAGCGACGAATTCGAAAGAAGGGAGCGTCGCTGTGTCAAACATACCGCAAGTGGATTTCGACGGTATAACTAATGACATCAATCAAGCTGTGACACTCCACTTACCAGATTTCAATTTAAGCTCCATTCAACCAATGCATAATATGGAATCGGAGACGAGTATTGGTGCGAACGTAATCGTGGAGCCAGTAATACCTCCGCCGCTAATCCCTGAGGATGACTTGACAAACCTACTCCTAAACCCTACGGAGTGGGATGATCTACAACTGGATATGCTCGACAACTACCTGGACTCATGTTTCAAGTAA
Protein Sequence: MHITSGLSPVSGEMLDTSALNFYGDAGDCGATYFAIDHAVPESSHTVEIEYVYEQPESHTEYQNDIDIDISETGTLIEVEVTAQAKDDHVEDEQDLTNLTWLQNITNIMSVPEFPLAPMSPNPQKVSPQNTRLQKFNQTIAKCQNDFMENKGEYQTNSEKKPPYSYSTLICMAMRYNNDKMTLSAIYSWIRENFKYYRKADPTWQEPGKGGFWKLDLAHLEGTKRISNRPHKKKKNSSETKQATNSKEGSVAVSNIPQVDFDGITNDINQAVTLHLPDFNLSSIQPMHNMESETSIGANVIVEPVIPPPLIPEDDLTNLLLNPTEWDDLQLDMLDNYLDSCFK

Sequence clustering based on sequence similarity using MMseqs2