Amun019536.1
Basic Information
- Insect
- Anorthoa munda
- Gene Symbol
- -
- Assembly
- GCA_945859655.1
- Location
- CAMAOM010000318.1:503464-520858[-]
Transcription Factor Domain
- TF Family
- SRF
- Domain
- SRF domain
- PFAM
- PF00319
- TF Group
- Helix-turn-helix
- Description
- Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 11 2.7 1.8e+04 -3.6 0.7 14 22 95 103 94 105 0.85 2 11 0.007 47 4.7 0.0 15 29 140 154 127 158 0.86 3 11 0.007 47 4.7 0.0 15 29 174 188 161 192 0.86 4 11 0.0028 19 5.9 0.0 14 31 207 224 194 226 0.76 5 11 0.0039 26 5.5 0.1 7 29 233 256 228 260 0.74 6 11 0.0024 16 6.1 0.0 7 31 267 292 262 294 0.74 7 11 0.0028 19 5.9 0.0 14 31 309 326 296 328 0.76 8 11 0.0028 19 5.9 0.0 14 31 343 360 330 362 0.76 9 11 0.0039 26 5.5 0.1 7 29 369 392 364 396 0.74 10 11 0.0054 36 5.0 0.1 14 29 411 426 399 430 0.79 11 11 0.0013 8.7 7.0 0.0 7 31 437 462 432 464 0.76
Sequence Information
- Coding Sequence
- ATGGAAAAAACCAACAAAGCGATGAAACAAGATCTACCTTCAGCGCCGCCGCAGAGACGTCGCGGTAGACCGGCAGGGAGAAACCGGGTGCCGTTAACACCGGCAGAGCGACGCGCGCGTAACGCGCAATATGAACGAGAGCGTCGAGAAGATCTGGCTGACGCTATTCACCAGTTAGCTGTAGCTGCCGGTGTTGACCCTAACATCCCGCTTGCAGACCTATTGGCAATCGTGGCCGATAAAATAGAGAAAGCGGGAGAAGCCGAGTCGAACTCGGAGATACGGCGTCAAAATAAAATACTGAAAAAACGAAATTCAGCGCCGCCGCAGAGACGTCGCGGTAGACCGGTAGGGAGAAGCCGGGTGCCGTTAACACCGGAAGAGCGATGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGCCGCCGGTTATAACCCTAACGAAGAGCGATGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGCCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGATAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCCGAACAATTAGCTGTAGTCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGCCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGTCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGATAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCCGAACAATTAGCTGTAGTCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGATAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGTCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGCCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATTCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGCCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCGAAAGCTGCTGAACAGTTAGCTGTAGCCACCGGTTATAACCCTAACATCCCGCTTGCAGACCTCTTGGAATTAGTGGCCGATAAAATAGAGAGAGCGGGAGAAGCCGAGTCGAACTCTGAGATACGCCGCGAAAAATAA
- Protein Sequence
- MEKTNKAMKQDLPSAPPQRRRGRPAGRNRVPLTPAERRARNAQYERERREDLADAIHQLAVAAGVDPNIPLADLLAIVADKIEKAGEAESNSEIRRQNKILKKRNSAPPQRRRGRPVGRSRVPLTPEERCARNAQLERERREGLAKAAEQLAVAAGYNPNEERCARNAQLERERREGLAKAAEQLAVAAGYNPNEERRARNAQLDRERREGLAKAAEQLAVVAGYNPNEERRARNAQLERERREGLAKAAEQLAVAAGYNPNEERRARNAQLERERREGLAKAAEQLAVVAGYNPNEERRARNAQLDRERREGLAKAAEQLAVVAGYNPNEERRARNAQLDRERREGLAKAAEQLAVVAGYNPNEERRARNAQLERERREGLAKAAEQLAVAAGYNPNEERRARNSQLERERREGLAKAAEQLAVAAGYNPNEERRARNAQLERERREGLAKAAEQLAVATGYNPNIPLADLLELVADKIERAGEAESNSEIRREK
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -