Amun019557.1
Basic Information
- Insect
- Anorthoa munda
- Gene Symbol
- -
- Assembly
- GCA_945859655.1
- Location
- CAMAOM010000318.1:880996-885346[+]
Transcription Factor Domain
- TF Family
- SRF
- Domain
- SRF domain
- PFAM
- PF00319
- TF Group
- Helix-turn-helix
- Description
- Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 9 0.0041 28 5.4 0.1 14 29 40 55 28 59 0.74 2 9 0.0036 24 5.6 0.1 6 29 135 159 131 163 0.74 3 9 0.0023 16 6.2 0.0 7 31 170 195 165 197 0.74 4 9 0.0023 16 6.2 0.0 7 31 204 229 199 231 0.74 5 9 0.0023 16 6.2 0.0 7 31 238 263 233 265 0.74 6 9 0.00094 6.4 7.4 0.0 3 31 268 297 266 299 0.83 7 9 0.0023 16 6.2 0.0 7 31 306 331 301 333 0.74 8 9 0.0021 14 6.3 0.0 6 31 339 365 335 367 0.75 9 9 0.0027 18 6.0 0.0 14 31 382 399 369 401 0.76
Sequence Information
- Coding Sequence
- ATGAAAAAATATCCAGATTCAGCGCCGCCGCAGAGACGTCGCGGTAGACCGGTAGGGAGAAACCGGGTGCCGTTAACACCGGAAGAGCGACGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGCCGCCGGTTATAACCCTAACATCCCGCTTGCAGACCTCTTGGAATTAGTGGCCGATAAAATAGAGAGAGCGGGAGAAGCCGAGTCGAACTCGGAGATACGCCGGAAAAATAAAAGACTGAAAAAACGAAGTATGTACCCTTTCTATAGTGACTTATCCAAATTCTCCTTACATTTTACAGTATTGTTAAATTTATTTATGAATACTTATTTGGCTTGTTTTTGTTCACAGGAAGAGCGACGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGCCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGTCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGTCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGTCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGTGCAATTAGATAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGTCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGTCGCCGGTTATAACCCTAACGAAGAGCAACGCGCGCGTAATGCGCAATTAGAAAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGTCGCCGGTTATAACCCTAACGAAGAGCGACGCGCGCGTAATGCGCAATTAGACAGAGAGCGTCGGGAGGGGCTGGCAAAAGCTGCTGAACAATTAGCTGTAGTCGCCGGTTATAACCCTAACATCCCGCTTGCAGACCTCTTGGAATTAGTGGCCGATAAAATAGAGAGAGCGGGAGAAGCCGAGTCGAACTCTGAGATACGCCGGAAAAATAAAAGACTGAAAAAACGAAAGAACCGTGTTCAGTGGACGCAGACATTGAAGTCACACAGTGTCAACACCTGCATTGACCGACTGACTACATACACTGTGTCTGTGGATTGGAACATCCAAAAAAAGACCCTTTTCAGGGCCGCATATGACTCAATATAA
- Protein Sequence
- MKKYPDSAPPQRRRGRPVGRNRVPLTPEERRARNAQLERERREGLAKAAEQLAVAAGYNPNIPLADLLELVADKIERAGEAESNSEIRRKNKRLKKRSMYPFYSDLSKFSLHFTVLLNLFMNTYLACFCSQEERRARNAQLERERREGLAKAAEQLAVAAGYNPNEERRARNAQLERERREGLAKAAEQLAVVAGYNPNEERRARNAQLERERREGLAKAAEQLAVVAGYNPNEERRARNAQLERERREGLAKAAEQLAVVAGYNPNEERRARNVQLDRERREGLAKAAEQLAVVAGYNPNEERRARNAQLERERREGLAKAAEQLAVVAGYNPNEEQRARNAQLERERREGLAKAAEQLAVVAGYNPNEERRARNAQLDRERREGLAKAAEQLAVVAGYNPNIPLADLLELVADKIERAGEAESNSEIRRKNKRLKKRKNRVQWTQTLKSHSVNTCIDRLTTYTVSVDWNIQKKTLFRAAYDSI
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- -
- 90% Identity
- -
- 80% Identity
- -