Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_031304115.1
Location
JAPWJP010003402.1:1361537-1369334[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.2 1.1e+04 -2.6 0.0 43 60 431 448 430 466 0.76
2 2 2.4e-17 2.1e-13 50.9 0.2 8 69 577 638 571 646 0.92

Sequence Information

Coding Sequence
ATGAAGCGGCGGCGTATACCGCGCTCGCGTGCCGTGGGGAGGGTATCGTCCGCCGTAACCGCGGCGGCAGCGGcgtcggcggcggcggcggcggcggcaacgGCAGCGGCTGCGGGGACGGGGACGGGGACAGGGACGGGAGCGGGGGCGATGGGAATGGCGCGCAAATGCTGCGTGCGTAGCTGCGAGGCGGACGTGCGGGAGGCGCGCGCCAAAGGGCTGCCGCTACACAAATTTCCCAAGGACGTAGCGCTGAGGGACAGGTGGTTGGCCAGCGGCGGGTTCGACGAGAGTTTCAAGCCGACGCCGGGCCAGGTCGTCTGCCACAGGCATTTCAAACGCGCCGACTACGACCATGCCGCGCGGGGCGGTCACAAGTTCCTGCTCAAGAGGGGCAGCGTGCCCACGGTTTTCGCGGACTATGACAATCATCCGGatCCAGTGATTATGTCAGTAAAATCTTCTACGTCTTATGCGCAAGAAGACTTGGATCTGATCAATTCAGAAATACTGAATTTGGAACATTCTACCTCGCCGTTATCCGAAGCAAGAACACCTAAATCCGATAGTTGCGGCGAGACATGTTATTCTAGACCTGAATCATCCATGGACTCGTTAAATCTACCTGATGGTTCAGAAGTAACGGACAACGAATGCAAAATGGCAAATTTGAAGGAAGAAATTGTGACATTAGTGAAAGACAAATTGGTTGAAAATTCGGATAGTAAAGTAAATACAGTAGCGATGCAACTTGGTATTGTTGAGGGAGCAACGATGAAGGCTGATGGTAAAGATCTAATAATAaaggaagaattaaaaaacattaaattgtcCGACGATAAGGAGTTTGATAAATCAGAAGAATTAAAACCAAAGGTTTTAAATCGCGATGGCACAAAGTTTTATCCTGGTGCCAAATTGGAAGCAAAAGACTTTAATGAAAAGTGgtaTTCTGCGAAAGTGGTAGAAACAGATTGGGATGAAAGAGaagttttaatacattttgacaAATGGAGTTCAAGATTTGACGAATGGATACCAATGGATAGCTCTAGACTCCGTGTATTGCAAACTCCCCCACACGAACAAACTTGGATCCTGCCATCTCCGGAGGCAAAGGTGCGAGAGTTTTCAGTGGGTGAAAGGGTACTGGCTACGTGGGCGGACGGTAGAAAATATCCGGCCAAAGTCAACACGGTCTTGACAAACGACAGGTACGATGTATTATTCGATGATGGATATGCGAAAATCGTCAAGTCCTCGAAAATGACCAAAATCGCCGAAAGTTCAGCCAAGCAGTTAAGTGAATTGGAAGGCTACATAGGCAGCAAACAAGAAAGAAGGGATAAGAAACGGAAACATACAGTTATGGAATTGTTTAACACTCACTCGAGAAGACGTACGAAAAATGATGCTGACAAAGCATCGAAGAAAGAGGAGACTGTCGTCAAAGAAAGTGGGGAAAGCTCCATAGAAAATAAGGTCGAAATGGATGGCACCTTATTTGGTGCCTGTTACGATCCAGGTACAGATTTACTAAGAGGCTTTGAGACTAATCCCTCAAAGATTAAATCATATTCAAAGAAAAGTAAGAAAGAAATGCCTAAAAATGATACGGATCACGAAGAAGATCCTGTTGGTCCTGAATGGATCGATGGAGAACCACAAGGAACGGAATCTTACATCGTAGATGGCAATGATGgaCCACGTCGCTCTATTATAGTACCAGATAGAAGATTACCTCCCGGTTGGGAGAAACACTTTACCCAAAGAAAAGCTGGTACATCTGCTGGAAAGTGGGATGTTCTATTTATAcaTAAGCAGACTGGGAAGAAGTTCAGATCTAGAAATGATATAAGAGTATTTATGGAGAATCAAGGACAATATGACTTTAATCCTGAAAATTTTGACTTCTGTATACATCGTCGAAAACGGAATCATGCGTCTCGCTTGAAACAAGAAGCTACaccagaaaaaaagattaaaacttTGTTACCCAAAACGAAAACATTGCCCACATCTGAGAATCCTTTACTGCAAGTGACAAATAATACAGCTGCATCGCCTAACCTCTCAACGCCTGTCACACCTGCTACGGATGGTGccGTTTTCATCGGACTTCGTGGTGGACTTCGTGTGGAAATGGAGGACAACGCCTATAAATGTCCCAAGGAaggatgtaataaaaattttcgaaaagaaaatttgctgcAAATGCACATCAAACATTATCATCCTGAATATTCCAAGTTTCTGGGTTCTACTCCAAAGGTTGAGGATTTGGCTTACGCAAGAACGATCGGAGAATCTATAGATGATATTATTCCAAAGAAATCGACGACATTCTTAgacaaaataaacaaatttgccAAGAAGAAATCTCTTCCGGAAAAATCGTCTACATTATTGCAATCAACATTAAACACCATGCAACCGACGTCTCCTTCGATACCTCATGCTGCTTCAGTTTTGCCAGAATTAGAAGAGGAAATTGATCAAGTGGAGAAATGTAATGATTCGCAGAAGGAGGAtatgaaaattgaaacaatGTCTTCGATATCTAATCACAGTATGGAGATTGACGACGATatcgagaagaaaagagaaaatacttGTGCATTGTCTCCAGGTACCCTATTTGACATGAAAGTTAAAGAAGAGAAACCACAAGGTGGAATTAAAACACTATTACCTGTAAGGCCATCTACAACATCAGAAGTGCAAAAAGTTGATAGAGTAAAATCGTTGGATGAAAATACGCACGTGGAACGTACGAAGGGCCAAAAGAAGAGACAAATCTCTGAACACAGTGTAGATTTACTGACTAAAGGAAAGAAACGACATGTTATGTCAGATCTTAATGACAGTTTCGGTGATCTAGACGACAGTGCTATGGATGCTGAAGGACCTGCAGCACTTATGTACAGATACAGTCGTAGAAAATCTGATTCAAAGAGTGATGAGAATAGTCAGAATAGTCAACTAAATGATTCTCGCATTGAAAAAGGTGATCCCTTAAAAGGGGATATAATCAaaacagatattaataatgatacagaagAAAGCGAAGGAGTGATGATGATGATCAACGGCGAAATGGTAAAGGTGGAACAACTTCGGAGAgaagagataataaattgtacatgTGGTTTTATGGAAGAAGATGGTTTAATGATACAGTGTGATCTTTGTCTCTGCTGGCAACACGGACATTGCAATGCgattgaaagagaaaaggatgttcctgaaaaatacatatgttacaTATGCCAACATCCTTATCGACAACGGCCATCTAAGAAATACTTTCACGATCAGGATTGGATTAAGGAAGGAAAACTGCCAAgtTTGTCTAATCGAACTCGGAATCAGCATACGATAAATCAGAGGACTGCGATGTTGAAGCGTTCCTACGACTTGGTTGCTGCACTTTTGCAAATACAACAACTTCTCCATAGCTTgcgtgtaaaaattaatgtggCTCAaaagaagGATCATCCCAAATTATATCTTTGGGCCAAGAATTgggaaaaaatggaaataccAAAAATAGATATAGAACCAGTACCAATAATGGAAATAGTGAAGACAGGACCGAGTTTTACAGATGTAGGTTTAGAAATTCCACGACGTGCTGAGACGAAAACGGATGTCAAATTACCTATAAAGGACGATCAAGATGAAAAATCAATCGCTTCAGATTCAgaattgatgaaaattttagaagaGGATAGCACGCATTCTGATGAATCTAagattatcaataaaaaagaaaactttgtCACCTCGAAGGATAGTCATATACTTTTGGACGCATTAACAAGCGGTAACTCGGACATAAAGGAAAGAAACGTTGCTATGTCAGACATTAAAACGGAGAATGCAGgtaataaaattatgagtgAAAATTCTACTTCTGAGAGTCTTTCTCTCAACTCGGGACCgcttattgataatattcaaCAAGAATCGAGTATAGCCGACGTTGAAAACGAAGTCTCCGCACTCCCGCAGCCTTTTATACCAGAGCCCGAAGCGCCGATTGATCCAACCGAATGTCGAATGAGATTATTGGAGCATATTGAACATTTTCAATGCCATCTTGATTCAAGATTAACGTCTATAGAAGCGCAAATTTGTgcTCTGGAGGCAATGGATCCAGATGAACTTACGTTGGATCCACACGTTCAGCCTCGTACTAAACAAACTGTACAGATGCTCCTTCGTGACTTGAGTACGGTCCGAAAGCTGGCAGCATTATGTTGA
Protein Sequence
MKRRRIPRSRAVGRVSSAVTAAAAASAAAAAAATAAAAGTGTGTGTGAGAMGMARKCCVRSCEADVREARAKGLPLHKFPKDVALRDRWLASGGFDESFKPTPGQVVCHRHFKRADYDHAARGGHKFLLKRGSVPTVFADYDNHPDPVIMSVKSSTSYAQEDLDLINSEILNLEHSTSPLSEARTPKSDSCGETCYSRPESSMDSLNLPDGSEVTDNECKMANLKEEIVTLVKDKLVENSDSKVNTVAMQLGIVEGATMKADGKDLIIKEELKNIKLSDDKEFDKSEELKPKVLNRDGTKFYPGAKLEAKDFNEKWYSAKVVETDWDEREVLIHFDKWSSRFDEWIPMDSSRLRVLQTPPHEQTWILPSPEAKVREFSVGERVLATWADGRKYPAKVNTVLTNDRYDVLFDDGYAKIVKSSKMTKIAESSAKQLSELEGYIGSKQERRDKKRKHTVMELFNTHSRRRTKNDADKASKKEETVVKESGESSIENKVEMDGTLFGACYDPGTDLLRGFETNPSKIKSYSKKSKKEMPKNDTDHEEDPVGPEWIDGEPQGTESYIVDGNDGPRRSIIVPDRRLPPGWEKHFTQRKAGTSAGKWDVLFIHKQTGKKFRSRNDIRVFMENQGQYDFNPENFDFCIHRRKRNHASRLKQEATPEKKIKTLLPKTKTLPTSENPLLQVTNNTAASPNLSTPVTPATDGAVFIGLRGGLRVEMEDNAYKCPKEGCNKNFRKENLLQMHIKHYHPEYSKFLGSTPKVEDLAYARTIGESIDDIIPKKSTTFLDKINKFAKKKSLPEKSSTLLQSTLNTMQPTSPSIPHAASVLPELEEEIDQVEKCNDSQKEDMKIETMSSISNHSMEIDDDIEKKRENTCALSPGTLFDMKVKEEKPQGGIKTLLPVRPSTTSEVQKVDRVKSLDENTHVERTKGQKKRQISEHSVDLLTKGKKRHVMSDLNDSFGDLDDSAMDAEGPAALMYRYSRRKSDSKSDENSQNSQLNDSRIEKGDPLKGDIIKTDINNDTEESEGVMMMINGEMVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYICYICQHPYRQRPSKKYFHDQDWIKEGKLPSLSNRTRNQHTINQRTAMLKRSYDLVAALLQIQQLLHSLRVKINVAQKKDHPKLYLWAKNWEKMEIPKIDIEPVPIMEIVKTGPSFTDVGLEIPRRAETKTDVKLPIKDDQDEKSIASDSELMKILEEDSTHSDESKIINKKENFVTSKDSHILLDALTSGNSDIKERNVAMSDIKTENAGNKIMSENSTSESLSLNSGPLIDNIQQESSIADVENEVSALPQPFIPEPEAPIDPTECRMRLLEHIEHFQCHLDSRLTSIEAQICALEAMDPDELTLDPHVQPRTKQTVQMLLRDLSTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00730116;
90% Identity
iTF_00867398;
80% Identity
iTF_00109883;