Basic Information

Insect: Anopheles stephensi
Gene Symbol: MBD-R2
Assembly: GCA_013141755.1
Location: CM023249.1:33361165-33364546[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.6e-15 6.5e-12 44.7 0.0 7 74 455 520 450 522 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.6e-15	6.5e-12	44.7	0.0	7	74	455	520	450	522	0.92

Sequence Information

Coding Sequence: ATGGGTATACGCAAGTGCATCGTGCCGGAGTGCCCGTCGTCGTCGGCCCGTCCGGAAGATCGTGGCGTTACGTACCACAAGATACCCTACCTAGAGGACATGAAGCGCTTGTGGATTGTTGCTTGCCATCTGCCGGATGATTACTTCGCCACGAAAGGCTCGAACGTATGCAGCCGTCACTTCCGGAAGGCAGACTTTCAGGAGTTTAAAGGTAAAAAGTATGTGCTCAAGTTTGGTGTGGTTCCAACCATATTTGCCTGGACGATCGCAAAACCATCGGCGGAAGATGCGGGAAAGAGCCCGCAGAAAACATCCAAAGCGAAAGAGGAAGCGGTCAAGGGACAGAAAGGAGCGGAAAAGTTTAAGGAAGAATTTACCCACGAAGTGGGTGATAATGATGAAAACATTGTGCTGAAAGAGGACGCAAAGGTTACAGCGCTGATGAAGAAAGAATCGTCCGAGAAGGAATCGCCCAAAACACCTGCTAAAAGAAAGTCTATACCTTCGTCGAAGCTCgctagtagtagcagcagtaagAAAGCGTCCGCTACGCCGGCAAAACAAGCGCGGACCGAACAACCGCCGGTTGCATCATCCACTAAAAAGCAAACATCGAAAAAAGGAGCCGCAGGGGAATCCAAGCAAGCGGTCGCCAGCGAAACACAgcctgctactgctgctgctgctgcagatgaaCCCGAGCCGGGTGGAAGCTCAGAAAAGTCAATCGATTTCACGCCGGGAACAAAGATCGAGGCACAAGATTTCAGCGGTACGTGGCATTCGGCCAAACTGGTCGAAGTCGACACCGAGGACAGGGAGGTGTTGGTACAGTTCGATAAGACGGACAAGCTTAAGTCGACCACACTGGAAGAATGGATATCGATGGACAGCGTGCGGCTGCGTCCCATCTCCAACTCAAACTACACCGTGGGCGAAAAGGTGTTTGCCCGGTGGAGCGATTCGCGAAAGTTTAAGGCCACAATTAAAAGCATCGTTGAGAACAACATGTACGAGGTGGTGTTTGACGATGGGTTTGCGAAGATCTGCAAATCGTCGCACATCAGTCGCATTAAGCGGTCCGAGGAAGCGAAGGCGGACACGGTTGAGAAGGATGCTGACGGTGGAGCGTCCGATGTGAATGCAACGATCAAGACGGAACCGGCTGAGGAAGGGACCGACGGTGGTGTAAGTGGACTGCTTTCGCTTAATCAGCTGCGTATTCCGCAGGTTGCCAAGTTGAGCGAACTGCCGGAAATTCCACAAACCGGGGAATGGTGCTGCCACTGGATGAACGACTATCCGGTCGGGGAACCGTCCGAGGTGGATCTACCGGGCGGCCGGGTGTACACCGTGATCGTGCCCGATTGGCGCATGCCGGAAGGCTGGGTGAAGCACATCTTTCAGCGCATAACAACGTACGGCAAGATGGACGTGCTGTTGATCAGCCCGTCCGGGAAGGTGCTCCGTTCCAGGCAGGAGCTGAAGACGTATCTGGCAGAAATCGGCGAAACGTACGATCCGAACATGTACGACTTTGGGCTGCACGTGAAGCGCTCGAAGCAGCTCGGGTTCTGTCACTACACGCAGGAGTACAAGGACAGCTTCCTGCCCAAACCGGCCTCGGAACCGATGCTGTTAAACACCGAGGTGAACATCGGTTCGGTGAAGGTGAAAATAATCGACAACCTGTTCCAGTGTCCCGAGGAGGATTGTTTGAAAACGTTCCGGAAGGAGAACCACCTGCAGATACACATCAAACACTACCATAAGGAGCTGGCGAAGGGGTTGGGCGACATTCCGAACATGCAAGATTTGGCCGCTCTGCGAACTCCGATCGAGCTGCTTGATTCACCGAAACCGGTCAGCCGCAAATCGCACGCCGCTTCCACGCCGAAAGCAGCAGTACCGCCCGTCGTAGTGAAGCAGGAAAAGATGGAAGAGGATGAGCAGGTTCCACCGGAAGCTGTAACGGAAGCTACGCCGACGGTAGACAGCAAACCGATTAAGGAAGATGTTTTAAAATCGCCCAAAAATGTGGAAGCTGATAAGCCAGCTGCAGATAAGCCGGATATGAAGGAGACCGCCGAACTCGGGGAAGCACAGGGCGGTGGGCAAGAAACGTCCGCCGAAGGCAGCGCACCTTCGACATCAACTCCAGCCGCAAGCGCCAAACCAAAGCCACCGAGTAAAGTGACAAAGATCAAGCTTTTCAGCCAGAAAAAGGCGTCCGGTGATATGAAAAAGATACGCCACGGTATGGTGTCGAAGAAGAAATCCTCCAAATCGAAGAAATCGAGACGATCCCGACCTGCACGACGGTCGGCAGCCGTGAATCGTACGGCACCGGCCATCCGTACGAACGATGCCAGTCTGCACGGGTCGTACCCGTACGGGAACTACAGTGGAACGTTCCACAATGAGATGAGCGGCGGATTTTATGACGATTCGATAAATGCCAGCGTCGGTGGCACCACAGCCGGGGTGGTCGATGAGAACGGGGAGGTCATAAAGATCGTACGCATGCGAAAGGAGGAGATCATCAACTGCATCTGCAAGGTAACGGAGGAGGACGGCTTGATGGTGCAGTGCGAGATGTGTCTCTGCTGGCAGCATGCCTTCTGTCAGAACATTCGCAGCAACAGCGAAGTGCCGGAAACGTACGTCTGCAGCATCTGTCGCTATCCGTACCGGGGCCGTACGTCGAAGCGGTACGCGCACGATCAGGATTGGCTGTACGAGGGAAAGCTGGCGGTGGCAAAGTATCATGCGGCCAACTCGAAGCACACGCAACGGTTCGACATACTGAAGAACTCGCACACGCTGACGGGCAATCTGCTCGAGCTGAAGCGCTTCATGCACAGCCTGCAGATGAAGATCAACATTGCGGAGAAGAAGGACCATCCGAAGATGTACCTGTGGTCGAAGAAGTGGGAGAAAAGTCCGCCGCGTGGCGACGGTAGCAGCAGTATGGTGGCGGTAGGCGAGAAGCCGCCCGGGGAAGGTGTCGGTCAGCAACAGATGCCCCAGATTCCGGTGCCGGAAGCCCCGATCGATCCGGCCGAATGTCAGGCGATTCTGCTCGATCACATCCAGAAGCAGCAGAACGATGCGATGGGACGGTTGCAGGCGATCGAGGCACAGATCATAGGACTGGAAGCTTACGATGAGAAGGCGGACCTGCTGGAATCTCCCACCGCGAAGAACTATCCCAAGACGAAGCAAACCATCCACATGCTGCTGAACGATTTGCTGAAAATGAAGAAGATTGCCGAAATTCATACGGATTTGCACAGTCTGTCGATGCAGTGA
Protein Sequence: MGIRKCIVPECPSSSARPEDRGVTYHKIPYLEDMKRLWIVACHLPDDYFATKGSNVCSRHFRKADFQEFKGKKYVLKFGVVPTIFAWTIAKPSAEDAGKSPQKTSKAKEEAVKGQKGAEKFKEEFTHEVGDNDENIVLKEDAKVTALMKKESSEKESPKTPAKRKSIPSSKLASSSSSKKASATPAKQARTEQPPVASSTKKQTSKKGAAGESKQAVASETQPATAAAAADEPEPGGSSEKSIDFTPGTKIEAQDFSGTWHSAKLVEVDTEDREVLVQFDKTDKLKSTTLEEWISMDSVRLRPISNSNYTVGEKVFARWSDSRKFKATIKSIVENNMYEVVFDDGFAKICKSSHISRIKRSEEAKADTVEKDADGGASDVNATIKTEPAEEGTDGGVSGLLSLNQLRIPQVAKLSELPEIPQTGEWCCHWMNDYPVGEPSEVDLPGGRVYTVIVPDWRMPEGWVKHIFQRITTYGKMDVLLISPSGKVLRSRQELKTYLAEIGETYDPNMYDFGLHVKRSKQLGFCHYTQEYKDSFLPKPASEPMLLNTEVNIGSVKVKIIDNLFQCPEEDCLKTFRKENHLQIHIKHYHKELAKGLGDIPNMQDLAALRTPIELLDSPKPVSRKSHAASTPKAAVPPVVVKQEKMEEDEQVPPEAVTEATPTVDSKPIKEDVLKSPKNVEADKPAADKPDMKETAELGEAQGGGQETSAEGSAPSTSTPAASAKPKPPSKVTKIKLFSQKKASGDMKKIRHGMVSKKKSSKSKKSRRSRPARRSAAVNRTAPAIRTNDASLHGSYPYGNYSGTFHNEMSGGFYDDSINASVGGTTAGVVDENGEVIKIVRMRKEEIINCICKVTEEDGLMVQCEMCLCWQHAFCQNIRSNSEVPETYVCSICRYPYRGRTSKRYAHDQDWLYEGKLAVAKYHAANSKHTQRFDILKNSHTLTGNLLELKRFMHSLQMKINIAEKKDHPKMYLWSKKWEKSPPRGDGSSSMVAVGEKPPGEGVGQQQMPQIPVPEAPIDPAECQAILLDHIQKQQNDAMGRLQAIEAQIIGLEAYDEKADLLESPTAKNYPKTKQTIHMLLNDLLKMKKIAEIHTDLHSLSMQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00108437;
90% Identity: iTF_00108437;
80% Identity: iTF_00108437;