Basic Information

Insect: Anopheles sinensis
Gene Symbol: Hr39
Assembly: GCA_000441895.2
Location: KE524975.1:91778-98076[-]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.056 4.3e+02 -0.2 1.0 121 176 89 148 15 164 0.68

2 4 1 7.9e+03 -4.3 2.5 65 131 251 266 217 300 0.39

3 4 3.3e-08 0.00025 20.3 0.0 1 20 465 484 465 490 0.93

4 4 2e-77 1.6e-73 248.3 0.0 156 408 565 827 553 827 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.056	4.3e+02	-0.2	1.0	121	176	89	148	15	164	0.68
2	4	1	7.9e+03	-4.3	2.5	65	131	251	266	217	300	0.39
3	4	3.3e-08	0.00025	20.3	0.0	1	20	465	484	465	490	0.93
4	4	2e-77	1.6e-73	248.3	0.0	156	408	565	827	553	827	0.91

Sequence Information

Coding Sequence: ATGGAGGAATCGGACGAATCCGACACGGAGCTGTCGAACATCGAGAAGACAGTGTCCGCCGTGGCACTGACCAATGGGGTGAATATGCGTGAGGAACGTAGCGCCAGCAAGGGAGCACCCCGGCCCATGTCGTGGGAGGGTGAGCTTTCGGAGCCGGAAGAACCGATGCTGGTGGACAACGAGAACAGCAGTTCGGGATCGAGCGTGAGTAAGCTGGCGAACGCACCATCGTCTTCCCCCGTGGCCATGATTGTGCCGAAGCAGGAAGAGGATCACGATCTGCCCACCAGTGGACCGGGCATTACGGAACCGCTTGCACTGACCGCGTCCAGCAGTAGCAACAGCGGTTACACTAGCGTTTCCCTGCACGGCCATAGCAGTAGTACCCACGCCGGGTTGAGAAATTCGAGCAGCTCCAGCAACTCACCACTTCCGAACCGTATGCTGATCAAACCGGAAGCAGGGCTTCCACTGATCAACCCGGGCCTGGCGTACAACGTCGCTGGCCTGGGCAATCCATCGTCCAACATTCCAACAGCAGCCGGAGGAGCTGCCTCAGCCCTCAAGAAGGGTCTTCCGGATGTGATAAACCTGAAGTACGAGCTGCCCCCCGGTGGGGTAGGTGATCCGGGTGGTGGCAGTGCGCTGCCACCGAACGCTATCCACTCGCCACTACTCGTCCGCTCCAAGACGACACTGCTGCCGGCCAATCCGAGCCCCGACTCGGCCATCCACTCGGTGTACACGCACAGCTCGCCCAGCCAGTCTCCGCTCACGTCACGCCACGCTCCGTACACGCCTTCGCTCAGCCGGAACAACAGCGATGCGTCGCACAGTAGCTGCTACTCGTACAGTTCAGAGTTCAGTCCGACGCATTCGCCCATCCAGGGACGGCACAGCATATTCGCCGGCGGTGGAAACGGCGGAGGCGTCGCGTCCTTCAATGGGTCTCCCCTGCATCANNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTCTACGACGGGGAGCATCTTCCATCACCCGGCATTTCCCGACAACAATTGATCAATAGTCCGTGTCCGATTTGTGGCGATAAAATCTCCGGTTTCCATTACGGCATCTTTTCGTGCGAGTCGTGCAAAGGTTTCTTCAAGCGCACGGTCCAGAACCGTAAGAACTACGTGTGCCTTAGGGGGGCGGCCTGCCCGGTGGCGATAGCGACGCGCAAAAAGTGTCCCGCCTGCCGGTTCGAGAAGTGCCTTCAGAAGGGGATGAAGTTGGAAGCTATTCGTGAGGATCGAACACGTGGTGGCCGTTCGACGTACCAGTGCTCGTACACTCTTCCTGGGCCGTTGGTGAATACGGCTGGCATGCAGGGAGGTGGTGAGTCGCCCGGTGTTGGTCCATTCCAGTACGGAGGATCGGTCCGATCGCCGTACGCTGCTGGCGGCGGTGGAGGCGTCGTTTCGAGCCAGCAGATGAAGGTGGAAACGAACGATGGCGCAGGTGGTATGATGATGTCAGGCGGTGGAAGTAACGGTGGACTGAACGGGATGGGCAATGGACCCAACGCCGACGGAAACGGTGGATCCAGTGGAGGTGGAAACCATATGCAACCAGGCATTCCAGTTCTGCTACAGGAAATTATGGACGTCGAACCATTGTGGCAGTACAACGCAGCGGAGCTGGCTCGGCTGAATCAACCTCCGCCGGCGGGTAACTGTACGAACATTGCGAACAATCCGCTGCTCTGCAGTGCCGGCATCTCTTCCGAGAGCAGTCCCGATCTGATTGCAAACCTCTGCAACATTGCTGACCATCGTCTGTACAAGATCGTTAAGTGGTGCAAGAGTTTGCCGCTTTTTAAGAATATTTCGATCGACGACCAGATCTGCCTACTGATCAACTCCTGGTGTGAGCTGTTACTGTTTTCATGCTGCTACCGTTCCATTGCAACACCGGGAGAGATCAAGATCTCCCTTGGGAAGTCGATCACACTGGAACAGGTTAAGAATAGTGGACTACAGACTTGCATCGAAAGAATGTTAAATCTAACGGATCATCTGCGACGATTGCGCGTCGACAAGTACGAGTACGTGGCGATGAAGGTGATCGTACTGCTTTCCTCGGACACTTCCGAGCTAAAGGAATCGGAAAAGGTTCGGGCAAGCCAGGAGAAAGCCCTGCAAGCGCTGCAAGCCTACACGTTGGCCTACTATCCGAAATCGCCGGCCAAGTTCGGGGAGCTTTTGCTGCGGATTCCAGAACTACAGCGAACATGTCAGGTCGGAAAAGAAATGCTCAACATCAAATCCAAGGACGACGAGGAACCCTCGTTCAACCTGCTGATGGAGCTGCTCCGCGGGGAGCACTGA
Protein Sequence: MEESDESDTELSNIEKTVSAVALTNGVNMREERSASKGAPRPMSWEGELSEPEEPMLVDNENSSSGSSVSKLANAPSSSPVAMIVPKQEEDHDLPTSGPGITEPLALTASSSSNSGYTSVSLHGHSSSTHAGLRNSSSSSNSPLPNRMLIKPEAGLPLINPGLAYNVAGLGNPSSNIPTAAGGAASALKKGLPDVINLKYELPPGGVGDPGGGSALPPNAIHSPLLVRSKTTLLPANPSPDSAIHSVYTHSSPSQSPLTSRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPIQGRHSIFAGGGNGGGVASFNGSPLHXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXYDGEHLPSPGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCLRGAACPVAIATRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPGPLVNTAGMQGGGESPGVGPFQYGGSVRSPYAAGGGGGVVSSQQMKVETNDGAGGMMMSGGGSNGGLNGMGNGPNADGNGGSSGGGNHMQPGIPVLLQEIMDVEPLWQYNAAELARLNQPPPAGNCTNIANNPLLCSAGISSESSPDLIANLCNIADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCYRSIATPGEIKISLGKSITLEQVKNSGLQTCIERMLNLTDHLRRLRVDKYEYVAMKVIVLLSSDTSELKESEKVRASQEKALQALQAYTLAYYPKSPAKFGELLLRIPELQRTCQVGKEMLNIKSKDDEEPSFNLLMELLRGEH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00107739;
90% Identity: iTF_00107739;
80% Identity: iTF_00107739;