Basic Information

Gene Symbol
-
Assembly
GCA_000349065.1
Location
KB667065.1:1534943-1538599[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.18 8.7 6.5 1.6 1 23 205 227 205 227 0.97
2 12 0.0018 0.086 12.8 0.4 1 19 231 249 231 252 0.94
3 12 0.00039 0.019 14.9 1.5 1 23 256 278 256 278 0.98
4 12 3.9e-06 0.00019 21.2 2.0 2 22 287 307 286 307 0.94
5 12 5.2e-05 0.0025 17.6 0.6 2 23 351 373 350 373 0.93
6 12 0.059 2.9 8.0 1.9 1 23 381 403 381 403 0.91
7 12 0.00015 0.0075 16.1 0.8 2 23 421 443 420 443 0.92
8 12 0.00064 0.031 14.2 5.1 1 23 450 473 450 473 0.93
9 12 0.00097 0.047 13.6 3.2 1 23 480 502 480 502 0.97
10 12 2e-05 0.00096 19.0 2.5 1 23 508 530 508 530 0.97
11 12 3.1e-05 0.0015 18.3 1.0 1 23 536 558 536 558 0.97
12 12 4e-05 0.002 18.0 0.3 1 23 564 587 564 587 0.97

Sequence Information

Coding Sequence
ATGGACGTACGTAAGCCAGATAGGCAATACAAGCGAATACACATGCAAGCCGATGGGGCGGGTGGTAGTAGTAAAAAGAAATTGTCCAAGACAGAGGAGAGCAACGTCAACTCTGGCTACGTCATCGAGGGAATGGTGATAGAGAAAACGGAAGTGGAGATACTGCCACCGGACATGTTGCTGAAGGCAGAGGCTGGAACTGAACAGTGTGGCGCCGTCATCAAACAAGAAGAGAACGAAGAGGAGGACCATCTGGTGGAGGAGCTGGTGTACGAGGAGCTGGACGAAACGGAACTCGACGAGGGTGAGATCATAGAAGAGGACAAGGATACGCTGGAGGGTGAACATGAGGGCGAAATGGTAGAGGAACACATCATGGAACATGAGGAAGACGTGATTGCGGCAGGGGACGAATCGGACGACCAAATTGAGCACCAGCTGTATGAGATTGCAGACAGTGAGGATGGGGATCATAAACAGCAGCAGGAGCAACAGCAGGATGACTGTTATTACGACGAAACGGTCAGCCGGTGCTACATCTGCATGGAAACGCTGGAATCGGAGAGCGTACTGCAAGAGCACCTGGGTGCGGTGCATCTTAAATTGCTCCCATTTCACTGCGACAAATGTTTGCAGTACTATCGCACAATTGACGAGGTAAATCAGCATCTGATCTCGCACGAGTATCCGTTCGTTTGCATGTACTGCCCGCGCAAGTACAGCTCCGAGCGGCAGCTGGAGAACCACAACAAAGACTGCAACACCTACCGGTGCCTGTACTGCCCGGCGGAGTTCGAGGTGCTGTCCCACCTGAACACACACAAGCGGCAACATGCGGCCCAGCTGCGGGGCAAGCTAAAGTGCAAGGCTTGCGGACGTCAGTTCACACAGTCGTCCCATCTGAAGCGCCATCTGCGGTCGGGGAGCTGTGCCGGCGTCAAGGAACGCGGACCAAAGCGCAAGTACATGCGTAGACAGGGGCAAGAAATTCCGACCTCCCCTAGAGGCGGCGACCATTGCAGCAAGGAGCCGCAGAACAAAAATCTACTCTACTGTCAGGTGTGCGATCGGAAGTTTGTCAGCAACTCCTATCTGGCGCGGCACTTCGAGCGGGACCATTCCGAGCTCCGGTTTCCCCTGTTTCCCTGTGACGTCTGTACGAAGAAGTTTACCTCGTTCGAAAAGTCCGTCCTGCACCGACGGTATCACCGCCGGCAGCCAGCGATCAAACCGAAGGAGCTAAAGAAACCGAAGGAAACGGTGTGCAAAATCTGCGGCAAAGAGTTCCGCGTCGACCATCAGCTGCTGCGCCATCTGACGGAGGAGCATTCACTCGCGCTCGAGCTGTTCCAGTGCGACCAGTGTCCGCGCAAGTTTTCCACCGAGTTCAAGCTGCGCAAGCACCATTACAACAGCCACCGGGAGAACAAGACGCTGTACGTTTGCTCGCACTGTGGGCAGAAGTTCGAGAAGAAGCTGACGCTGAAGGACCACGAAACGAAGCACCTGGGTATGCCGGCCTATCGGTGCGCGGTGTGCGACAAGACGTTCATTCACAAGCACAGCCTGGACCGGCACGCGCTCGTGCATAGTGACGAGAAGCAGTTCGCGTGCGAGTTTTGCGCGAAAACGTTCAAGCGCAACACCACGCTGGTGATCCACCGGCGGATACACACCGGGGAGAAGCCGTACCAGTGCGAACCGTGCGGTATGCGGTTCATCGATTCCAGCACGCTGATCAAACACCGGCAGCGGGCGCACATGAAAGCGGAGTGCATGCCGTTGAAACAGGAACAAAGGCAGTAG
Protein Sequence
MDVRKPDRQYKRIHMQADGAGGSSKKKLSKTEESNVNSGYVIEGMVIEKTEVEILPPDMLLKAEAGTEQCGAVIKQEENEEEDHLVEELVYEELDETELDEGEIIEEDKDTLEGEHEGEMVEEHIMEHEEDVIAAGDESDDQIEHQLYEIADSEDGDHKQQQEQQQDDCYYDETVSRCYICMETLESESVLQEHLGAVHLKLLPFHCDKCLQYYRTIDEVNQHLISHEYPFVCMYCPRKYSSERQLENHNKDCNTYRCLYCPAEFEVLSHLNTHKRQHAAQLRGKLKCKACGRQFTQSSHLKRHLRSGSCAGVKERGPKRKYMRRQGQEIPTSPRGGDHCSKEPQNKNLLYCQVCDRKFVSNSYLARHFERDHSELRFPLFPCDVCTKKFTSFEKSVLHRRYHRRQPAIKPKELKKPKETVCKICGKEFRVDHQLLRHLTEEHSLALELFQCDQCPRKFSTEFKLRKHHYNSHRENKTLYVCSHCGQKFEKKLTLKDHETKHLGMPAYRCAVCDKTFIHKHSLDRHALVHSDEKQFACEFCAKTFKRNTTLVIHRRIHTGEKPYQCEPCGMRFIDSSTLIKHRQRAHMKAECMPLKQEQRQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00095800;
90% Identity
iTF_00095800;
80% Identity
-