Basic Information

Insect: Anopheles minimus
Gene Symbol: gsb-n
Assembly: GCA_000349025.1
Location: KB663755.1:979949-1000427[+]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 2.6e-65 3.4e-62 207.5 0.4 1 110 22 131 22 139 0.97

2 2 0.012 16 5.0 0.0 106 125 151 167 148 167 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	2.6e-65	3.4e-62	207.5	0.4	1	110	22	131	22	139	0.97
2	2	0.012	16	5.0	0.0	106	125	151	167	148	167	0.84

Sequence Information

Coding Sequence: atggatatGTCAGGTTCGAATTCGCTAAACATGAGACCACTGTTTAGCGGATATCCTTTTCAAGGTCAAGGACGTGTGAACCAGTTGGGGGGAGTGTTTATCAATGGACGACCATTGCCAAATCACATTCGGCTGAAAATAGTCGAGATGGCCGCATCTGGGGTGAGGCCCTGCGTGATTTCACGCCAGCTGCGTGTTTCCCATGGATGTGTATCGAAAATCCTAAACCGCTACCAAGAAACCGGTTCGATTCGTCCCGGCGTAATAGGTGGCTCGAAACCCAAAGTAGCGACACCGGAAGTGGAAGCTAGAATCgaagagatgaagaaaatgaatccCGGAATTTTTAGCTGGGAAATACGGGAAAAGTTGATTAAGACGGCCGGCTCGGATGACCCCAGCGATAATAGACATTCTGGTCAACTAGGACCTGATGTGGGCTATCGGCAGGAAGGAGTAACGGATCCCCCCAGCGTATCATCTATAAGCCGACTTCTGAGAGGTGGCGGTGCAGAGCCAGGACGGAAAGATGACGACGGTCGGAAGGATTACAGCATACACGGTATTCTCGGAGGACGCGGATCGGACTCGAGTGACACCGAATCGGAACCGGGAATACTACTGAAGCGGAAACAACGTCGATCGAGGACCACCTTCACGGGTGAGCAGCTGGAAGCATTGGAAAAGGCCTTCCAGCGTACGCAGTATCCGGATGTTTACACCCGCGAAGAGTTAGCCTCCACCACCAACCTGACCGAAGCGCGCATACAGGTATGGTTTAGTAATCGTCGTGCCCGGCTTCGTAAGCATGCCGGAGCGCAAATGACCACGCCGCTGAGCAGCTTGGGCACTCTGCCAATGTCGCAGTATCACCCGGGAGTTGCGTCTAACGATTCGTACCAAATGGCGGCAGCGGCCAACTATGAGTTCGTTGCGCAAAACCCCTCCACCTTTTCCTCCGGCCATTTCCAGCATGGCCACTTTGGGGGACAAAACTTTACAACCAATCATCACATGGGCTTCCACCAAAACAATCAAGAATTCCTTCCTTCCGAATACACCAAAATGATGAGCGAAGAGTACATTAAGCCGGCGCatgaaaattccatcaaaCTAAGCCCTTCAACAACGCAGGCAGAAAACTACGTTAAAGTACCGCCTGCCCCTCCGGCAGCGGCGCCCATCGTCACGCAGGAAACCCCTTGGAGTCAGTCCTATCCGCCCCATCATCCGGGTCAGGCTTACGCCACCAACTTGGTTGGCTGTCCACCACCGGTTACGACCGCTACTGCAGCAGAGTATCATTCGATGCAACAGGCGGCCACCTCCTATCCTAACAAATATTGGTCCTGA
Protein Sequence: MDMSGSNSLNMRPLFSGYPFQGQGRVNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIGGSKPKVATPEVEARIEEMKKMNPGIFSWEIREKLIKTAGSDDPSDNRHSGQLGPDVGYRQEGVTDPPSVSSISRLLRGGGAEPGRKDDDGRKDYSIHGILGGRGSDSSDTESEPGILLKRKQRRSRTTFTGEQLEALEKAFQRTQYPDVYTREELASTTNLTEARIQVWFSNRRARLRKHAGAQMTTPLSSLGTLPMSQYHPGVASNDSYQMAAAANYEFVAQNPSTFSSGHFQHGHFGGQNFTTNHHMGFHQNNQEFLPSEYTKMMSEEYIKPAHENSIKLSPSTTQAENYVKVPPAPPAAAPIVTQETPWSQSYPPHHPGQAYATNLVGCPPPVTTATAAEYHSMQQAATSYPNKYWS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00101629;
90% Identity: iTF_00093409;
80% Identity: iTF_00104994;