Amel006493.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles melas
Gene Symbol
-
Assembly
GCA_000473525.2
Location
AXCO02018927.1:2-3460[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.0011 0.062 13.6 6.4 1 23 190 212 190 212 0.98
2 14 2.2e-07 1.2e-05 25.3 0.2 1 23 245 267 245 267 0.98
3 14 4.7e-07 2.5e-05 24.3 0.8 1 23 273 295 273 295 0.98
4 14 1.1e-06 5.7e-05 23.2 3.5 1 23 301 323 301 323 0.98
5 14 0.00022 0.012 15.9 0.7 1 19 329 347 329 350 0.95
6 14 1.6e-05 0.00087 19.4 0.8 1 23 356 378 356 378 0.98
7 14 1.8e-07 9.8e-06 25.6 1.1 1 23 387 409 387 409 0.99
8 14 9.9e-07 5.3e-05 23.2 0.7 1 23 415 437 415 437 0.99
9 14 0.02 1.1 9.7 0.3 1 19 444 462 444 463 0.95
10 14 0.00025 0.013 15.7 1.1 1 23 570 592 570 592 0.98
11 14 4.2e-07 2.3e-05 24.4 1.1 1 23 668 690 668 690 0.97
12 14 2.9e-05 0.0016 18.6 0.6 1 23 696 718 696 718 0.93
13 14 3.5e-05 0.0019 18.4 2.2 1 23 726 748 726 748 0.98
14 14 6.1e-08 3.3e-06 27.1 0.6 1 23 754 776 754 776 0.99

Sequence Information

Coding Sequence
ATCTTCTTTCCCCCGCCTCCCCTCAAGATTATCTACGAGCGCAACCTGCCAATGTTTGTGTGCAAACTGTGCGCCAACAAGCTGGACGAGTACGTGCGATTTCGGGACCGGTGCATCGCGAACGACGAGTTCCTGCGCAATGCGCTGGCCGCCTTCGATGCGAACGGTGGGGGCAGCTGTCCCGGTGCGATAAAAATGGAACCGGACGACACTACCCACCCCGCCGTACCACCTCAACCGCCAGCCAGCGCCAAGTTTGCCCAATGCCTTGCGGTAACACCGCTCGAGCTTAACTGTGCCCTGGTGGCGGCTGCTGCAGCCGCCGCCGGCAAGCGGGAACCGCCCGACATCGAGGAGGAAGACGAGGAGCGGGGCTATGGGCACGGGTCCGGAGCTCCGTCTCCCGATCGGTCCGCCTGTGGCCGGGTGGACGAGCTTACGGTCAAACGGCCGCACAGCGACGAACCCCACTATCGCAGTGGCGACGAAGACGACGAACTGCTAGCGGACGATGGGTACGACGGTGAACCCAACCAAACGCCGGCGGGCCACGCCGACCAGCAGCAGTACGTGTGTGAGGTGTGCTCGAAATCGTTCAAAATCCGGCACCATCTGCTGGTGCACCGGCACACGCACGTGGACAGCCACGCGCCAACGGCGGACGTGCTGCACGAGCGGGGCGACTTTAACGGTACTTCGCCCGGTGCCGGTGGGGCCGGCGGCAAACCGTCGTACAGCTGCCCCAAGTGCCCGAAAGCGTTCGTCAACAAGGGCAACCTGCTGAACCATCTCGAGACGCACACGCACGAGAAGAGCTACGCGTGCGACATCTGCACGAAAACGTTCAAGTACAACGTGCAGCTGCGGCTGCATATGCGCATCCATACCGGCGAGCGGCCGCACAAGTGCGAGATCTGCAATCGCGGCTTTTCCCAGCTGTCGAACCTGCGATCGCACCGGAAAACGCACTCCAAAGTCAAACCGTACAAATGCCACCTTTGCCTCAAAAGCTTCACCATGCTGGACAACCTGACCGCGCACAGCGCCAAGTGTCTGAAGGACAAGTTCCGCTGCACGCTCTGCTCGAAATCGTTCGCGAAGGAGGGCAACCTGCTGTCCCATCTGCAGTCGCACAGCGACGGCATCGTGGAGAAGATGTTCAAGTGCGAGATGTGCCCGAAAAGCTTCAAGAACAAGGAGGACTGGAAGCGGCACGTCCGCGTGCACACGGGCGAAAAGCCGTACACGTGCGACATCTGCTCGAAGGGGTTCGCGCAGAAGGCGAACCTGCTGTCCCACCGGAAGACACACCTCAAGCCAAACGTTACGTACAGCTGCGACCGGTGCGCCCGGACGTTCCGCTCGCAGAAGGTGCTGCAAATGCACGTGCCAAAGTGTACCGGTGGGGCGGGACCGATCGAGGGTGCGAGTGTGCCACCCTCGGCACCGGTAACCCCCGTGTCCGAATCAATCCCGGACTCGCCCAGCCCCGGTGCGGGCGTGTCGCTGACGACGACATCTTCTTCGGCAGTGGACGCGTCCGCCAACAGTACACCGCCGACCCTGTCCGAAGCGCTGTCCGATCTGTTGCGGTACGAGATTGCACTGCGGGCACCGCTCGAGCTGCAGCAGATGCTGCTGGGGCACATCGACCGGAAGGGCAAACCGGCGCAGGCCGGTCCGGGTGGTAAGGCGGCCGGGCGGCGGTACCGGTGTGACGTCTGCTTCAAGGGCTACTCGCAGTACCCGTCGCTGATCAAGCACCGCAAGCTACACTTCAAGGTACCTCCGCTGGTAAAGGTCCTGGCAGGGAAGGCGGGCCACCATCACCAGCAGGACTACGAGGACGGGGAGATGGAAGAGCCGAGCGACGGTCTCGTGCAGCCACCGGGGGAGCTCCACTGTCGGGGAGTTGGAGGGATCGGAGATGCACCACCACAACCACTACCACCACTACCACCACCACACCACCAACCGACTGGCGAACCGATCGAGCGGCCGTACAGCTGTGATATATGCGGTAAGACCTTTAAATACAATCGTAACCTGAAGGTGCACGCCAAGCTGCACGTCAGAGCGAACCGTTTTAAGTGTGACAAGTGTACCACCACCTTTGCGCAGGCGGAAGATTTGCGGCGGCATCTGCCCACCCACCCGACCGCTGCCGGCAGGAGCTTCAGCTGCGACTACTGTGCGAACCGGTTCCGGTCGAGCGAGGACCTGAAGCGGCACCGCCGGTCGCACACCGGCGAGCGGCCGTACCGGTGCACCCGCTGTCCGAAGGCGTTTACGCAGCAGTCGAACTTGCGGGCCCACGCGAGGATCCACGACCGATAG
Protein Sequence
IFFPPPPLKIIYERNLPMFVCKLCANKLDEYVRFRDRCIANDEFLRNALAAFDANGGGSCPGAIKMEPDDTTHPAVPPQPPASAKFAQCLAVTPLELNCALVAAAAAAAGKREPPDIEEEDEERGYGHGSGAPSPDRSACGRVDELTVKRPHSDEPHYRSGDEDDELLADDGYDGEPNQTPAGHADQQQYVCEVCSKSFKIRHHLLVHRHTHVDSHAPTADVLHERGDFNGTSPGAGGAGGKPSYSCPKCPKAFVNKGNLLNHLETHTHEKSYACDICTKTFKYNVQLRLHMRIHTGERPHKCEICNRGFSQLSNLRSHRKTHSKVKPYKCHLCLKSFTMLDNLTAHSAKCLKDKFRCTLCSKSFAKEGNLLSHLQSHSDGIVEKMFKCEMCPKSFKNKEDWKRHVRVHTGEKPYTCDICSKGFAQKANLLSHRKTHLKPNVTYSCDRCARTFRSQKVLQMHVPKCTGGAGPIEGASVPPSAPVTPVSESIPDSPSPGAGVSLTTTSSSAVDASANSTPPTLSEALSDLLRYEIALRAPLELQQMLLGHIDRKGKPAQAGPGGKAAGRRYRCDVCFKGYSQYPSLIKHRKLHFKVPPLVKVLAGKAGHHHQQDYEDGEMEEPSDGLVQPPGELHCRGVGGIGDAPPQPLPPLPPPHHQPTGEPIERPYSCDICGKTFKYNRNLKVHAKLHVRANRFKCDKCTTTFAQAEDLRRHLPTHPTAAGRSFSCDYCANRFRSSEDLKRHRRSHTGERPYRCTRCPKAFTQQSNLRAHARIHDR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00101096;
90% Identity
iTF_00107129;
80% Identity
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