Afon006937.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles fontenillei
Gene Symbol
-
Assembly
GCA_008817895.1
Location
VTWG01007606.1:19196-23613[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.0011 0.062 13.5 6.4 1 23 242 264 242 264 0.98
2 14 2.1e-07 1.2e-05 25.2 0.2 1 23 298 320 298 320 0.98
3 14 4.5e-07 2.5e-05 24.2 0.8 1 23 326 348 326 348 0.98
4 14 1e-06 5.7e-05 23.1 3.5 1 23 354 376 354 376 0.98
5 14 0.00021 0.012 15.8 0.7 1 19 382 400 382 403 0.95
6 14 1.5e-05 0.00088 19.3 0.8 1 23 409 431 409 431 0.98
7 14 1.7e-07 9.8e-06 25.5 1.1 1 23 440 462 440 462 0.99
8 14 9.5e-07 5.4e-05 23.1 0.7 1 23 468 490 468 490 0.99
9 14 0.019 1.1 9.6 0.3 1 19 497 515 497 516 0.95
10 14 0.00023 0.013 15.6 1.1 1 23 623 645 623 645 0.98
11 14 4e-07 2.3e-05 24.3 1.1 1 23 717 739 717 739 0.97
12 14 2.8e-05 0.0016 18.5 0.6 1 23 745 767 745 767 0.93
13 14 3.3e-05 0.0019 18.3 2.2 1 23 775 797 775 797 0.98
14 14 5.8e-08 3.3e-06 27.0 0.6 1 23 803 825 803 825 0.99

Sequence Information

Coding Sequence
atggCAGAAGATTTATcgatcaataaaaataagatTTTTACCCAACGGTACGGCAACAGTAATAACGACATCTGTCGGCTTTGTCTAAAAAATGAAGCCCACATGGAGCCATTGTTCTACGCGAACCTGTTCCCAAACATTTTACTCACGAAAAAGATATACGATTGCACCTCGATACAGATTATCTACGAGCGCAACCTGccaatgtttgtgtgcaaacTGTGCGCCAACAAGCTGGACGAGTACGTGCGATTTCGGGACCGGTGCATCGCGAACGACGAGTTCCTGCGCAATGCGCTGGCCGCCTTCGATGCGAACGGCGGGGGCAACTGTCCCGGTGCGATAAAAATGGAACCGGACGACACTGTCCACCCCGCCGTACCACCTCAACCAGCAGCCAGCGCCAAGTTTGCCCAATGCCTTGCGGTAACACCGCTCGAGCTTAACTGTGCCCTGgtggcggctgctgcagccgccgccggCAAGCGGGAACCGCCCGACATCGAGGAGGAAGACGAGGAGCGGGGCTATGGGCACGGGTCCGGAGCACCGTCTCCCGATCGGTCCGCCTGTGGCCGGGTGGACGAGCTTACGGTCAAACGGCCGCACAGCGACAGCGAACCCCACTATCGCAGtggcgacgaagacgacgagcTGCTAGCGGACGATGGGTACGACGGTGAACCCAACCAAACGCCGGCGGAGCACgccgaccagcagcagtacgtgTGCGAGGTGTGCTCGAAATCGTTCAAAATCCGGCACCATCTGCTGGTGCACCGGCACACGCACGTGGACAGCCACGCGCCAACGGCGGACATGCTGCACGAGCGGGCCGACTTTAACGGTACTACGCCCGGTGCCGGTGGGGCCGGTGGCGGCAAACCGTCGTACAGCTGCCCCAAGTGCCCGAAAGCGTTCGTCAACAAGGGCAACCTGCTGAACCATCTCGAGACGCACACGCACGAGAAGAGCTACGCGTGCGACATCTGCACGAAAACGTTCAAGTACAACGTGCAGCTGCGGTTGCACATGCGCATCCATACCGGCGAGCGGCCGCACAAGTGCGAGATCTGCAATCGCGGCTTTTCCCAGCTGTCGAACCTGCGATCGCACCGGAAAACGCACTCCAAAGTCAAACCGTACAAATGCCACCTTTGCCTCAAAAGCTTCACCATGCTGGACAACCTGACCGCGCACAGCGCCAAGTGTCTGAAGGACAAGTTCCGCTGCACGCTCTGCTCGAAATCGTTCGCGAAGGAGGGCAACCTGCTGTCCCATCTGCAGTCGCACAGCGACGGCATCGTAGAGAAGATGTTCAAGTGCGAGATGTGCCCGAAAAGCTTCAAGAACAAGGAGGACTGGAAGCGGCACGTCCGCGTGCACACGGGCGAAAAACCGTACACGTGCGACATCTGCTCGAAGGGGTTCGCGCAGAAGGCGAACCTGCTGTCCCACCGAAAGACACACCTCAAGCCAAACGTTACGTACAGCTGCGACCGGTGCGCCCGGACGTTCCGCTCGCAGAAGGTGCTGCAAATGCACGTGCCAAAGTGTACCGGTGGGGCGGGACCGATCGAGGGTGCGAGTGTGCCGCCCTCGGCACCGGTAACCCCCGTGTCCGAATCAATCCCGGATTCGCCCAGCCCCGGTGCGGGCGTGTCGCTGACGACGACATCTTCTTCGGCGGTGGACGCGGCCGCTAACAGTACACCGCCGACCCTGTCCGAAGCGCTGTCTGATCTGTTGCGGTACGAGATTGCACTACGGGCACCGCTCGAGCTGCAGCAGATGCTGCTGGGGCACATCGACCGGAAGGGCAAACCGGCGCAGGCCGGTCCGGGTGGTAAGGCGGCCGGGCGGCGGTACCGGTGTGACGTCTGCTTCAAGGGCTACTCGCAGTACCCGTCGCTGATCAAGCACCGCAAGCTACACTTCAAGGTACCTCCGCTGGTAAAGGTCCTGGCAGGGAAGGCgggccaccatcaccagcaggaCTACGAGGACGGGGAGATGGAAGAGCCGAGCGACGGTCTCGTGCAGCCACCGGGGGAGCTCCACTGTCGGGGAGTTGGAGGGATCGGAGatgcaccaccacaaccaccaccaccacaccaccaaccGACCGGCGAACCGATCGAGCGGCCGTACAGCTGTGATATATGCGGTAAGACCTTTAAATACAATCGTAACCTGAAGGTGCACGCCAAGCTGCACGTCAGAGCGAACCGTTTTAAGTGTGACAAGTGTACCACCACCTTTGCGCAGGCGGAAGATTTGCGGCGGCATCTGCCCACCCACCCGACCGCTGCCGGCAGGAGCTTCAGCTGCGACTACTGTGCGAACCGGTTCCGGTCGAGCGAGGACCTGAAGCGGCACCGCCGGTCGCACACCGGCGAGCGGCCGTACCGGTGCACCCGCTGTCCGAAGGCGTTTACGCAGCAGTCGAACCTGCGGGCCCACGCGAGGATCCACGACCGATAG
Protein Sequence
MAEDLSINKNKIFTQRYGNSNNDICRLCLKNEAHMEPLFYANLFPNILLTKKIYDCTSIQIIYERNLPMFVCKLCANKLDEYVRFRDRCIANDEFLRNALAAFDANGGGNCPGAIKMEPDDTVHPAVPPQPAASAKFAQCLAVTPLELNCALVAAAAAAAGKREPPDIEEEDEERGYGHGSGAPSPDRSACGRVDELTVKRPHSDSEPHYRSGDEDDELLADDGYDGEPNQTPAEHADQQQYVCEVCSKSFKIRHHLLVHRHTHVDSHAPTADMLHERADFNGTTPGAGGAGGGKPSYSCPKCPKAFVNKGNLLNHLETHTHEKSYACDICTKTFKYNVQLRLHMRIHTGERPHKCEICNRGFSQLSNLRSHRKTHSKVKPYKCHLCLKSFTMLDNLTAHSAKCLKDKFRCTLCSKSFAKEGNLLSHLQSHSDGIVEKMFKCEMCPKSFKNKEDWKRHVRVHTGEKPYTCDICSKGFAQKANLLSHRKTHLKPNVTYSCDRCARTFRSQKVLQMHVPKCTGGAGPIEGASVPPSAPVTPVSESIPDSPSPGAGVSLTTTSSSAVDAAANSTPPTLSEALSDLLRYEIALRAPLELQQMLLGHIDRKGKPAQAGPGGKAAGRRYRCDVCFKGYSQYPSLIKHRKLHFKVPPLVKVLAGKAGHHHQQDYEDGEMEEPSDGLVQPPGELHCRGVGGIGDAPPQPPPPHHQPTGEPIERPYSCDICGKTFKYNRNLKVHAKLHVRANRFKCDKCTTTFAQAEDLRRHLPTHPTAAGRSFSCDYCANRFRSSEDLKRHRRSHTGERPYRCTRCPKAFTQQSNLRAHARIHDR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00107129; iTF_00102503; iTF_00093608; iTF_00104531;
90% Identity
iTF_00107129;
80% Identity
-