Amel001046.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles melas
Gene Symbol
TFAP2A
Assembly
GCA_000473525.2
Location
KI920383.1:7638-21346[+]

Transcription Factor Domain

TF Family
AP-2
Domain
TF_AP-2 domain
PFAM
PF03299
TF Group
Basic Domians group
Description
Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.56 8.7e+03 -3.8 0.1 161 178 141 155 133 159 0.62
2 2 1.7e-74 2.7e-70 236.1 0.0 16 196 215 393 203 394 0.96

Sequence Information

Coding Sequence
ATGGCATTGGCGTACGTAGACATGTCATCCGTTATCGAAGTGCAGGAGCGGCTCACTAGTCATGGAGGCATAGGGCTGTCGAGCGGAAGTCCTGCATACTCGGCGCACACCGGCGGCCACACGGGGCGCAACGGCCCAGCGAGCGGACACAGCGGTAGCCACGGCGGTTCACACGGTCCCGGCCCGACCATGCATCACCAGACGCTGCAGTCCGACTTCCAGCCACCGTACTTCCCGCCACCGTTCCACCATACCACCCAAAGCCCACCGCAGCAACAGAACCACGGTCTCGATTATTTAAGCACGGACCCGTACGGGCAGCCACTGTCCTCGCTACACCATGCGCCCCTGCACCACTACAATCAGCTGGCCGGGCTGAGACCGTCACAGGAGCAGCTCGGGTTACACCGATCTCACCGCGAGTCCGAACTGCAGCAGCACGTGACGCAACTGTCGCACGGCTTCCCGTACTCGGACCGGCGCAGCGATTACAGCGGCTCGATCGGTTCCGGTGCCGGTGCAACCCGGCTCGGTGCCCACGAACACGATCCGCTCGCACTGCACCAAGCGCTGCAGAGTGCCGTCGACGATGGGCAGAATCCGGTGATAGACGAGAACGCGGGCTTTATGAGTGATCTGCCACTGCTGAAAATCACCGTCGCGGAAGTGCAGCGCCGACTATCGCCACCCGAGTGTCTGAACGCGTCCCTGCTGGGCGGTGTCCTGAGACGAGCGAAGAGTAAAAACGGCGGACGATTGCTGAGGGAAAAGTTGGAAAAGATTGGCCTGAACCTGCCGGCCGGTCGGCGTAAGGCGGCGAACGTTACCCTGCTAACGTCGCTGGTGGAAGGGGAGGCCATCCATCTGGCGCGTGACTTTGGGTACGTGTGCGAGACCGAGTTCCCGGCCCGGCAGGTGGCGGAATATCTATCGCGCCAGTACTCGGAACCGCAGGAGTCGTACCGAAGGAAGGAGCTGCTGCTCAACACCAAGCAGGTCACGAAGGAGCTGATGGACCTGCTGAACCAGGATCGATCGCCGCTCTGCAATACCAGACCCCAGCACATACTCGATCCCTCGATACAGCGACATCTGACGCACTTTTCGCTGATCTCACACGGTTTCGGTTCGCCGGCCATCGTTGCGGCACTGACAGCAATTCAGAACTATCTGAACGAATCGATCAAACATCTGGACAAGATGTACCCGGGCAACGGTGGCAGCATGGTGACCTCCTCGCTAGACAAGAACAAAATGGAGAGCGACAAGAAATGA
Protein Sequence
MALAYVDMSSVIEVQERLTSHGGIGLSSGSPAYSAHTGGHTGRNGPASGHSGSHGGSHGPGPTMHHQTLQSDFQPPYFPPPFHHTTQSPPQQQNHGLDYLSTDPYGQPLSSLHHAPLHHYNQLAGLRPSQEQLGLHRSHRESELQQHVTQLSHGFPYSDRRSDYSGSIGSGAGATRLGAHEHDPLALHQALQSAVDDGQNPVIDENAGFMSDLPLLKITVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEAIHLARDFGYVCETEFPARQVAEYLSRQYSEPQESYRRKELLLNTKQVTKELMDLLNQDRSPLCNTRPQHILDPSIQRHLTHFSLISHGFGSPAIVAALTAIQNYLNESIKHLDKMYPGNGGSMVTSSLDKNKMESDKK