Basic Information

Gene Symbol
tfap2e
Assembly
GCA_013758885.1
Location
NC:1369096-1420721[-]

Transcription Factor Domain

TF Family
AP-2
Domain
TF_AP-2 domain
PFAM
PF03299
TF Group
Basic Domians group
Description
Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 0.31 3.5e+03 -3.0 0.1 157 178 136 154 126 161 0.64
2 2 3.6e-84 4e-80 267.7 0.0 1 196 239 432 239 433 0.98

Sequence Information

Coding Sequence
ATGATTATGACACTCACACCGTCCCTGCAATCACAGctgGAGCGGCTTACTAGTCATGGAGGCATAGGACTGTCCAGCGGAAGTCCTGCTTACACAACGCACGCCGGCGGCCACACGGGGAGAAACGGACCAGCGAGTGGGCACAGCGCTAGTCACGGCGGTTCACACGGTCCCGGTCCAACGATGCATCATCAGACGCTACAATCAGACTTCCAGCCGCCCTACTTCCCGCCACCcttccaccacaccacccaaAGCCCACCCCAGCAACAGAACCATGGACTGGACTATCTGAGCACGGATCCGTACGGTCAGCCACTTTCCTCGCTGCACCATGCGCCCCTGCACCACTACAACCAGCTGGCCGGGCTGAGACCGTCGCAGGAGCAGCTCCAAGGACTACACCGATCTCATCGCGAATCCGAACTCCAGCAGCATGTGACGCAACTTTCGCACGGTTTCCCGTATTCGGACCGGCGAAGTGACTACAGTGGCTCGatcggttccggtgccggtgcaaccCGGCTAGgcgcacacgaacacgaccCGCTGGCCCTGCACCAAGCGCTCCAGAGTGCGGTCGACGATGGCCAGAATCCGGTGATAGACGAGAACGCAGGCTTCATGAGCGATCTGCCACTGCTGAAGAACTTCCCCATCACCGACATCAAGAAGGATAGCAGCCAAATCAACATCGGATCACCGAGCGAcgtgttctgttccgttcctgGGCGACTCAGTCTCCTGTCGAGCACCTCAAAATACAAAGTAACGGTGGCGGAGGTACAGCGTCGACTGTCCCCGCCCGAGTGTCTCAATGCGTCACTGCTCGGCGGTGTTCTCAGACGGGCAAAGAGTAAAAACGGTGGCCGACTGTTGAgggaaaagctggaaaaaaTCGGACTCAATCTGCCGGCAGGACGGCGTAAGGCAGCGAATGTAACGCTACTGACGTCACTGGTGGAAGGAGAGGCCATTCATTTGGCTCGCGACTTTGGGTACGTGTGTGAGACCGAGTTTCCGGCGCGCCAGGTTGCCGAGTATCTGTCACGGCAGTACTCGGAACCGCAGGAATCGTATCGAAGGAAGGAGCTGCTACTCAACACAAAACAGGTCACCAAGGAGTTGATGGACCTGTTGAACCAAGATCGATCCCCGCTCTGCAATACCAGACCGCAACATATCCTGGATCCGTCGATACAGCGACACTTGACGCACTTTTCGCTGATCTCACATGGTTTCGGTTCACCAGCCATCGTTGCCGCCTTGACAGCAATTCAAAACTATCTGAACGAATCCATCAAGCACCTGGACAAGATGTACCCGGGCAATGGAGGCAGCATGGTCACGTCGTCGCTAGACAAGAGCAAAATGGAGAGCGACAAGAAATGA
Protein Sequence
MIMTLTPSLQSQLERLTSHGGIGLSSGSPAYTTHAGGHTGRNGPASGHSASHGGSHGPGPTMHHQTLQSDFQPPYFPPPFHHTTQSPPQQQNHGLDYLSTDPYGQPLSSLHHAPLHHYNQLAGLRPSQEQLQGLHRSHRESELQQHVTQLSHGFPYSDRRSDYSGSIGSGAGATRLGAHEHDPLALHQALQSAVDDGQNPVIDENAGFMSDLPLLKNFPITDIKKDSSQINIGSPSDVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEAIHLARDFGYVCETEFPARQVAEYLSRQYSEPQESYRRKELLLNTKQVTKELMDLLNQDRSPLCNTRPQHILDPSIQRHLTHFSLISHGFGSPAIVAALTAIQNYLNESIKHLDKMYPGNGGSMVTSSLDKSKMESDKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01190906;
90% Identity
iTF_00104085;
80% Identity
-