Basic Information

Gene Symbol
-
Assembly
GCA_943734865.1
Location
CALSEK010000112.1:488513-490874[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.097 5.2 7.6 2.0 6 23 243 260 243 260 0.98
2 14 0.58 31 5.1 0.1 6 23 271 289 266 289 0.85
3 14 1.3e-05 0.00068 19.8 1.0 1 23 297 319 297 319 0.94
4 14 0.00098 0.052 13.9 0.8 2 23 328 349 327 350 0.93
5 14 1.4 74 3.9 0.4 2 23 401 423 400 423 0.89
6 14 6.3 3.4e+02 1.9 1.9 6 23 433 450 428 450 0.89
7 14 1.9e-05 0.00099 19.3 0.8 1 19 456 474 456 479 0.94
8 14 0.0075 0.4 11.1 4.3 1 23 487 509 487 518 0.96
9 14 0.028 1.5 9.3 3.3 3 23 519 540 517 540 0.96
10 14 0.00064 0.034 14.4 0.1 2 23 547 568 546 568 0.96
11 14 2.6 1.4e+02 3.1 7.1 1 23 578 601 578 601 0.96
12 14 0.00057 0.03 14.6 1.9 2 23 608 629 607 630 0.94
13 14 0.00038 0.02 15.1 0.5 1 23 636 658 636 658 0.97
14 14 0.027 1.4 9.3 1.4 1 23 664 687 664 687 0.91

Sequence Information

Coding Sequence
ATGAACGCTAATAAAGATCTGCCGGTCAGCGATGAGGTTTGCTTACTGTGTCAGTTAAATAGCAACGATCGTCACTTTCTCGCTGAGCGAACAGCAATCGGCAGTGAATCGATTGCAGACGTTATTTGCAAGCATTTCTGGCTATCGGAAATCGCTTGCAAGGATCGCTACATCTGCCCAAAATGCTGGGACATAACCTTTTCCTTCCACCAGTTCTACAACCAAATAGAAAGGCTGCATGCGGTGCAACCAACGGTTAAGCAAGAGCACTGCTTCACAGAGAGCAAACCGATCGACACAAGCGAACATGTAGACTGGTTGCAGGAAGAAAGCACACCGTTTAGAAATGAAATCTACGTAAAAGAAAACTACACGGACAGTGACGATGAATCAAAAATCGGGCAGCATATCGAATCTGTCGATCGGGACGAAGAATCCGACAGCGATTCAAACATTCCTTTGGCAGTGCTCAAGAAAGGAAACAATGCGCGACAACAGAGCAATGCATCAGCAGCCCACGACAAACCTTCACCGTATCCCGGTGTCGGTTTGTCCTTATGCCGCATCAAGGGTAGCACACTGGAGCTAATGTGTTACGACTGTTTCCGTCTGGCGAACAATGGTAGCAAGTCTTCTGCGCCAAAAGTGACCGAAGAACGCTTCACCTTTGCTGCACTGCTGAAACACTATCGCCAGGAGCATAACAAAAATGGATATGCAGTTTGCTGTAGTCGCAAATACACGCGGCGAAGATCGTTGAAGATGCATCTGCTGTCGCATGGCCGGACGGTTGTGTATCGATGCATTCCCTGTGGTATTAAATTTCGCAAACAAGACTCGTTGGACGAGCATAACTTGCTTATTCACACAGCGGAGGAGGAAAAGCGATACAAATGTGACGAGTGTGATAAATCGTTCGCAACCGAACACCTCCTGCAATCGCACGGCACGTGGCATGAGAATGTAGCGAAAAAGAATATAAGTTGCAAACTTTGCAATATATTCTTTGCCAGCCAACCGTCGCTAGAAAAGCATCGAGCATTGCACCATCCAGCCTTGGACAGCACCGAGACGGCATCAAGCAACAACAGTGGCACAGAAACCGCCGAAGACCGGATAGTTTCATCGCAATATCGTACGCGTATTTCGGCGACTGAAATTAGCGAACAGGAGCAACTTATCAAGCGCCACTGTTTGCTAAATTGCAGCAGGTGTGACTACTTCGCGGAAAACTTCACAAGCCTCAAGCAGCACGCGATACAGGTTCACAGTCAGCGAAGTTGCGATGTGGTGTGCTGCGACCGTACGTACAGCAAACGGCAATCACTTTACGAACACTGCCTGGTACACGAAAATCCCGACTGTTTTCGTTGCGATGTGTGTGGCAAAAGCTACTCCAGCAGCCGGAGTCTACAGAACCACAAATGGCGCATACATACACCGGCGGCCCAGCGGCCGTTCTGCTGCGACGTGTGCGGCGAAACGTTTGTGAAGGATTATTTGCTGAAGCAGCATCTGGTACATCATTTGGCGAAGCATAAAAAGCTGAACCACTGCAATGTCTGTGAGCGATCGTTTACGACCGCGACAGTGCTGAAGTGCCACCAGCAAACGTTTCACGGCGGTGGGTTCAACTGGATCTGTGATATCTGTGCGAAAGGGTTCAACAGTCGGGCGCTGTTCGAGAATCATCGCTTGACCCACTCGGTCGAGGGAAAGTCGCAGTTGAAGCATCAATGCGAACAGTGCAAAAAATGGTTGCGAAACAAAAAATCCTACCAACAGCATCGGATACGCTGCCACACTAGCGATGGACCGGTGACTTGTAAATTCTGCGGCAAAGAATCCGTCAATGCGAGTGCTCTCAAGTCGCACATTCATCTGCATCATACATCGCGGCCCGAGTATCCCTGCACGTTATGTAGCAAAAGCTTCAAAACGGCACTGCGCCTGCGGGAGCATGAAGCAACACACACGGGTACGATACTGTACCGATGTCCGTGGTGTCCGCGTACCTTTGCCTGTGGCTCGAACATGTATAAGCATAAGAAGGCAGGCCATCCGCTAGAATGGGCCGCCTCCGTAAAGAAACGGTTCGGTGAGCGATGA
Protein Sequence
MNANKDLPVSDEVCLLCQLNSNDRHFLAERTAIGSESIADVICKHFWLSEIACKDRYICPKCWDITFSFHQFYNQIERLHAVQPTVKQEHCFTESKPIDTSEHVDWLQEESTPFRNEIYVKENYTDSDDESKIGQHIESVDRDEESDSDSNIPLAVLKKGNNARQQSNASAAHDKPSPYPGVGLSLCRIKGSTLELMCYDCFRLANNGSKSSAPKVTEERFTFAALLKHYRQEHNKNGYAVCCSRKYTRRRSLKMHLLSHGRTVVYRCIPCGIKFRKQDSLDEHNLLIHTAEEEKRYKCDECDKSFATEHLLQSHGTWHENVAKKNISCKLCNIFFASQPSLEKHRALHHPALDSTETASSNNSGTETAEDRIVSSQYRTRISATEISEQEQLIKRHCLLNCSRCDYFAENFTSLKQHAIQVHSQRSCDVVCCDRTYSKRQSLYEHCLVHENPDCFRCDVCGKSYSSSRSLQNHKWRIHTPAAQRPFCCDVCGETFVKDYLLKQHLVHHLAKHKKLNHCNVCERSFTTATVLKCHQQTFHGGGFNWICDICAKGFNSRALFENHRLTHSVEGKSQLKHQCEQCKKWLRNKKSYQQHRIRCHTSDGPVTCKFCGKESVNASALKSHIHLHHTSRPEYPCTLCSKSFKTALRLREHEATHTGTILYRCPWCPRTFACGSNMYKHKKAGHPLEWAASVKKRFGER

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00108635;
90% Identity
-
80% Identity
-