Basic Information

Insect: Anopheles gambiae
Gene Symbol: -
Assembly: GCF_000005575.2
Location: NT:25828275-25837398[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 0.00017 0.0087 16.0 2.2 2 23 385 406 384 406 0.97

2 10 5.8e-09 3e-07 30.0 1.2 1 23 412 434 412 434 0.99

3 10 8.6e-05 0.0044 16.9 0.1 1 23 440 463 440 463 0.95

4 10 0.00069 0.035 14.1 0.7 1 23 472 494 472 494 0.96

5 10 0.0026 0.13 12.3 0.0 2 23 501 522 500 522 0.96

6 10 6.9e-06 0.00035 20.4 1.5 1 21 532 552 532 553 0.96

7 10 1.4e-06 6.9e-05 22.6 0.8 2 23 561 582 560 582 0.93

8 10 5.1e-06 0.00026 20.8 6.6 1 23 588 610 588 610 0.99

9 10 1.3e-05 0.00065 19.5 2.5 1 23 616 638 616 638 0.99

10 10 0.0005 0.025 14.5 3.3 1 23 643 666 643 666 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	0.00017	0.0087	16.0	2.2	2	23	385	406	384	406	0.97
2	10	5.8e-09	3e-07	30.0	1.2	1	23	412	434	412	434	0.99
3	10	8.6e-05	0.0044	16.9	0.1	1	23	440	463	440	463	0.95
4	10	0.00069	0.035	14.1	0.7	1	23	472	494	472	494	0.96
5	10	0.0026	0.13	12.3	0.0	2	23	501	522	500	522	0.96
6	10	6.9e-06	0.00035	20.4	1.5	1	21	532	552	532	553	0.96
7	10	1.4e-06	6.9e-05	22.6	0.8	2	23	561	582	560	582	0.93
8	10	5.1e-06	0.00026	20.8	6.6	1	23	588	610	588	610	0.99
9	10	1.3e-05	0.00065	19.5	2.5	1	23	616	638	616	638	0.99
10	10	0.0005	0.025	14.5	3.3	1	23	643	666	643	666	0.98

Sequence Information

Coding Sequence: atggaaagtgTGCTAGATTTCAGCGTTATTTGCCATACCTGTTTAAGTGTAACGCCGAGTACGATATCGGTGAAGAGTACAGATCTTAAGTACAATGTCCCGCTCGCCACAATGATCAACAAAATCAGCGCATTCGAGCGCCAAGACAACCCGAGGCTTCCGGACAGATTGTGTTTCGTGTGTGCGGAACAGCTCCGGATCGCGTACGGCTTTCAGCAGATGTGTGACGATTCGTACCGGATTCTTCTCATCCAATTGGAGAAACAACCGGAGCCAGTAGTACCAAAGGAAGAACCCGTCATCATCGACGTGGACGCGCTAGGGATGTCTGAAACTGAGCAGGATGAAAGCGAACAGAAAGAGATTAAACAGCTTGAGACGAAGCATAGTGTGGCGAAGCAGAATGAGACGAAGCAAATTGCGCCGATACTGAGTGAGGTGGCGAAGCCGATTGAGCCGAAACTGAGCGTGGTGGCGAAGCAGATTGAGCCGAAACAGAATGAGACGAAGCAGATTGAGCCGATACAGAGTGGGTCGAAACTGAATGAGACGCGGCAAGATGTGCCGAAACAGATTGAGCCGAAACAGATTGCGATGGAACCGATTGTGATGGGGCATGATGTCATAGAGCAGGATGCCATGGAGCAGGATGCCATGGAGCAGGATTTCATCGAGCAGGATGCCATGGAGCAGGATGGCACGGAACAGTACGACACGGAGCAATATGACACGGAGCAGTACGACACGGATCAGTACGACACAGATCAGTACGACACGGAGCAATACGACACGGAGCAATACGACACCGAGCAGGATGACACGGAGCAGGATGACACGGAGCAGAATGGCACGGAGCAGAATGGCATGGTACTCGAAAATGGCTTTATCTCGCCTAGCACCTCCACTGCACCAATGAGCTCAATGAGCAGCGATGTACGAAAATCAGAACTAAGCGAGCTGTTGAACGAAGCCGAATACCTCGAGGAATATCTCATGGCCGATCCCGAAGAGCCAACCGAAGAGCAGTTCCCTAAGCCAGCCCCGATCGGCGGTGCCACTGTAGCGGAAGCGGAAGACAATAACAATGGCATCGAGGACGATCTCCAGTCCATAGTCGTGCCCGGCGAGGATGGAATACGCGAAATTCAGAACCAATGCCACGTGTGCGGGCTCATTCTGAGCAAGCTGGCGCATCTGAAACGCCACATGAAGGCGCACGCCGGAACCAAACCGTTCAAGTGCAACGTGTGCTCGAAGTCGTTCTCCCGCGCGGACAATCTGCGGGCGCACCAAAGGATGCACACGGCGGAGAAGAACTACAAGTGTCCGCTGTGCGACGAACGCTTCAAGCGTGTCGATGCGGCCAAGGCGCACATGGGCTCGGCGCATCGCGACTTCGTGGAGGCCAACTACCACGTGTGCACGGTGTGTGACAACTTCTTCAAGACGGACGAGAAGCTGATCGCGCACATGGAGCTGCACAGGGGCGTCAACAGGCTGGTGTGTGACGTGTGCGGCAAGCAGTTCGTGGGCATGATGGCGTACGAGGCCCACCTGCAGCGGCACGCGGCCGAGTCGGAACAACCGACCACGTACTCATGTGCGCACTGTGACAAGAAGTTTTCCAGCAAAGCGTACCTGTTGATGCATATGCGCTACATGATGGCAAACAAATGCTTGGAGTGCAAGTACTGTGGTAAAAAATTTGCACGCCAGAGTGAGTTGAAGTCGCACGAAGATTACCATACCGGGATCAAGCCCTTCACCTGCAAGACCTGCGGGAAGAGCTTCCATCGTCAGTGTACGCTCGTCGTACACATGCGAACGCACACGGGAGAAAAACCGTTCCAATGTTCGTACTGTCCCAAAAGCTTCTACCAGAAGAACGACATGCTGACGCACGAGCGGCGCCATACGGGTGAGCGGTACCAGTGTGAATTTTGTGAGCAAAAGTTTATTCACCTGCACCTGCTGAATTCGCATCTGAAGGTAGTACACAACCATGACGTGGATTGCCGAAAGCGGGGTGTGAAGAAGTTTTTCGACGAACCCGGTCCGACGGTTTTTGCGGCGAAGGAACCGAAGCCCGAGTAG
Protein Sequence: MESVLDFSVICHTCLSVTPSTISVKSTDLKYNVPLATMINKISAFERQDNPRLPDRLCFVCAEQLRIAYGFQQMCDDSYRILLIQLEKQPEPVVPKEEPVIIDVDALGMSETEQDESEQKEIKQLETKHSVAKQNETKQIAPILSEVAKPIEPKLSVVAKQIEPKQNETKQIEPIQSGSKLNETRQDVPKQIEPKQIAMEPIVMGHDVIEQDAMEQDAMEQDFIEQDAMEQDGTEQYDTEQYDTEQYDTDQYDTDQYDTEQYDTEQYDTEQDDTEQDDTEQNGTEQNGMVLENGFISPSTSTAPMSSMSSDVRKSELSELLNEAEYLEEYLMADPEEPTEEQFPKPAPIGGATVAEAEDNNNGIEDDLQSIVVPGEDGIREIQNQCHVCGLILSKLAHLKRHMKAHAGTKPFKCNVCSKSFSRADNLRAHQRMHTAEKNYKCPLCDERFKRVDAAKAHMGSAHRDFVEANYHVCTVCDNFFKTDEKLIAHMELHRGVNRLVCDVCGKQFVGMMAYEAHLQRHAAESEQPTTYSCAHCDKKFSSKAYLLMHMRYMMANKCLECKYCGKKFARQSELKSHEDYHTGIKPFTCKTCGKSFHRQCTLVVHMRTHTGEKPFQCSYCPKSFYQKNDMLTHERRHTGERYQCEFCEQKFIHLHLLNSHLKVVHNHDVDCRKRGVKKFFDEPGPTVFAAKEPKPE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00104539;
90% Identity: iTF_00101105;
80% Identity: -