Afun011946.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles funestus
Gene Symbol
litaf
Assembly
None
Location
Contig0:40880108-40882645[+]

Transcription Factor Domain

TF Family
zf-LITAF-like
Domain
zf-LITAF-like domain
PFAM
PF10601
TF Group
Zinc-Coordinating Group
Description
Members of this family display a conserved zinc ribbon structure [3] with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS)[2]. The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.1e-20 4.1e-17 61.8 15.4 1 68 68 137 68 138 0.94

Sequence Information

Coding Sequence
ATGCCGACGATTCATGATAGGCTGCTTGCGAAATTCGACATGACTAAAGATGGACCGCCACCGTACGGGTTTGTGCCACCACCATCGGCACCACCGAGCTATGCGCAGGCTGTCGGAGGTGTACCACCGTCCAGCCCGTTTACACCGCAGCAACCGGTACTGACCGGGGCACAGATTGTGACGACGGTCGTACCGATCGGACCACAATCGACACACATGATATGTCCCAGCTGCCATTCAGAAGTCAACACCAAAACGACAACATCGCCAGGAATGATCGCTTACGTGTCCGGTTTCCTGATCGCACTGTTTGGATGCTGGTTGGGATGCTGCCTAATACCGTGCTGCATTGACGAATGTAATGGATGCTACATCATACGTTGTCCTCACTGTAAAGCCTATCTGGGACGGCAATAG
Protein Sequence
MPTIHDRLLAKFDMTKDGPPPYGFVPPPSAPPSYAQAVGGVPPSSPFTPQQPVLTGAQIVTTVVPIGPQSTHMICPSCHSEVNTKTTTSPGMIAYVSGFLIALFGCWLGCCLIPCCIDECNGCYIIRCPHCKAYLGRQ