Basic Information

Insect: Anopheles funestus
Gene Symbol: mecom-b
Assembly: None
Location: Contig1:83332412-83430975[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 6.8 4.1e+02 1.5 2.5 2 23 301 323 301 324 0.92

2 9 0.00035 0.021 15.0 0.1 1 23 330 353 330 353 0.96

3 9 0.00012 0.007 16.5 0.7 7 23 395 411 395 412 0.92

4 9 1.7e-06 0.0001 22.3 1.7 1 23 418 440 418 440 0.95

5 9 1.6e-05 0.001 19.2 5.9 1 23 446 468 446 468 0.99

6 9 0.004 0.24 11.7 1.3 2 21 476 495 475 496 0.95

7 9 2e-09 1.2e-07 31.5 1.1 1 23 1061 1083 1061 1083 0.99

8 9 1.8e-06 0.00011 22.2 1.6 1 23 1089 1112 1089 1112 0.97

9 9 0.00016 0.0095 16.1 6.7 1 23 1118 1140 1118 1140 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	6.8	4.1e+02	1.5	2.5	2	23	301	323	301	324	0.92
2	9	0.00035	0.021	15.0	0.1	1	23	330	353	330	353	0.96
3	9	0.00012	0.007	16.5	0.7	7	23	395	411	395	412	0.92
4	9	1.7e-06	0.0001	22.3	1.7	1	23	418	440	418	440	0.95
5	9	1.6e-05	0.001	19.2	5.9	1	23	446	468	446	468	0.99
6	9	0.004	0.24	11.7	1.3	2	21	476	495	475	496	0.95
7	9	2e-09	1.2e-07	31.5	1.1	1	23	1061	1083	1061	1083	0.99
8	9	1.8e-06	0.00011	22.2	1.6	1	23	1089	1112	1089	1112	0.97
9	9	0.00016	0.0095	16.1	6.7	1	23	1118	1140	1118	1140	0.99

Sequence Information

Coding Sequence: ATGCGGTCCAAGTCTGTCGCACGACGATTCGCTCAAGGCATCAGTGGCGACGAATCGGACGCATCCCGTGGACTACCCGTCAATCTAGAAGTACCTCCAGGGCTGCAGGTGGTACCGATGAGCAAACACCACGATCACGGACCGGCTGACTTTAGCTTACCAACATCGCTGCATCATCATCTTCTACCCACAGCAGATGATGTTCGCGAGCGGTTAAAGCTGCAGAGTGCGGAACAGTTCCTTCTACAGATGGCGCGACTACAGCGTCCGCCACCACCAGATCTGGACATTCAGACCGGTTCGGTTGTGGCGCTCAAAACCATCCCCAAGGGTACACAGTATGGACCTTTCGTGGGCAAACTGCTGCGAGAACCAATGGATCGACGGTTTGCTTGGGAGGTGATAGATGTAGATATTCGTGGCTGGTTAGATGCAACACTGGAACCAACGAACTGGATGAAACACATACGCTGCACCTCCAGCTCAGGCGAAGCGAACGTGCAACACTTTCTCAAAGATGGTCATCTGTGGTACGAAGTGATATGTGATATCAGTCCCGGAAGGGAACTGTTGCTGCGACCGAAGGTTCCTCTTCATCCCAGGGATGGGCAAGACGAGCGAAGCAGCGAACGTGGCTCGGGCGGTTCCCAGCACAGCGACAACTACGAGGACGAGTACAATACCTCGAACGATCTTGACTCTAGTCACAACAAGGAGCAGCACCATCATCACAACAGTAGCAGCAGCAACAGCAGCGGCAGAAGTAGCAACGGCAGCAGTACCCGTGCGAACGGACACCATCCCGGGGACGACAGTGGTAACGGAAGTGGTGAACCGCACCAACATCATCACCATTCGGACGTAAAGGAGGAGGACGAGGACGAGCACGGTATTGACGCGCGGTGTGTCGTCTGTGATCGGCAGTGTCACGATATTGATCAGCTTGACGATCATCTCGTGATCTCGCACCATTATCCAAAGGACGCCTACAGGTGTGAGCTTTGTCCGAGGGCATACAGCTACAGACCGTCGTTGCTGCGACATCGAGCGATCGTACACGGTGAGCTGCGGCGCTTTCCGTGCGAAAACTGTCCCAAAAACGAAGATACCGATGTGAGCACAGCAACCCCCAACACTTCCTCATCGAGCGAACTATTCAGTTACCTTCTGCAAGCTCATGATAATAGGGTTTTCACCGATCCGTCGAATTTGCAGCGTCACATCCGGACACACCACGTGGGAGCCCGTAGTCACGCGTGTCCAGAGTGTGGCAAGACGTTTGCCACCTCGTCCGGTCTAAAGCAGCACACGCACATCCACTCGTCGGTGAAGCCGTTCCAGTGCGAGGTGTGCTTCAAATCGTACACCCAGTTCTCAAACTTGTGCCGTCACCGGCGTATGCACGCCGATTGCCAGGTGCAGATCAAGTGTAACAAGTGTGGCGATAGCTTCAGCACAACTACGTCCCTTTCGAAGCATAAGCGTTTCTGTGACTCAACCGCCGTTACGCGTGCCTCACTACACTCGGGAGCCCATCCATCGCATCTGCGCCATCCGCACGATCCTTATCCGCACGGACGGCCACACCCGGGAGCGGGTCAGCAAGGTACCGCCGGTGGTACGGGCGGAGCATCCGCAATTGCAGCCGGTACTGGAGCAGGACCACTTCACACGCTACCACCCGGTATGGCAACTCCACCGAATCCATTCCTTATGTTTCCCGGTGCACCTTTCTTTGCGCCCGGATTTCGACCATATCCAGGCATGCCGGGTATTTTTCCACCGGCACCGGGACAGGTTCCCCAGTTTCCGCTGTCCTTCTTCCCGAAGCCGGCGGCACCGGGACCACTGCCCGAACCGGAACGCAGAACCCCGTCGCCATCGTCTCGGCATCTTGGTTTGCTCGAAAGTTACGGTCAGCAGTCGATGAAGATTTCACCACCGACCGGTGAGGAGGCCACAAACCATCTGCGACCGTCACCGGCACGTCCCATTCCGGTTAGCTTCAACTCAGCGGCAGCAGCTGTTGCGTTGCTGTCGGGATCGCCTGGCCCATTAATGGGCAATCATAATATTCCTGCAACGGAATCGGTTCAGGAGCGAGGCAACAACAACAATCACATCAAGGAAAACAACAATCACAATCACACGAACGGTACCAGTTCCTACGGTGGACAGACCGCCCAACAACAGCAGCAGAGACGAACTTCAAGCCGCAGCAGCTCGGTAACAGCAGCGACCACCGTCAAGGAAGAATTGGCCCGTGATTCTTCCGATACCGAGGAAGGAGATACCGGACTGTCTGCGATTCGAGTGAAGAATTTCTCTACACGATCCAAGAACGCATCCGGAGAGACGAGCAAGTCCCCTGCATTGTCAGAAAACAGGAGTCAATCGCACCGTAGAAGAAGCCGTACGGTGGAAGATGGTGATACGTCAGAATCTGAGGAATTCTCGTCTGAAGCAAAGAAGGCAAAGAAGGAGGAAGAAGCTTCCGGTTCTGCAGAGCAACCGTTGGATCTGAGTCTTTCGAAGAAGTTAAAAAACGACGATGTGGACGACGGTGTTGAGGCAGATGAGGATAAGGATGGGTCGGAGGAGATGGTGAATCGTAGCTCGAACCGCAGTCCAACGCCCATTGAAGTGACCAGCCCAAGGTCCACACCGACACCGTCAGTTCCAACACCCAACTCTTCGGACGTACCCCATCATGACCTATCGCTGAGAGCACGTGGCCGGAACACTACCGGCTCATCGATCTCACCGAAAGCGGCATCCGCATCCCCACTAGCGGATGCATTCCCTCTACCAAGCCCCTCACCATCGCTCTCACCGCGTCCCTCACCGTCACCCTCATCGCCCGGTGGCGTTACAGGGTCTGGTCCACATCATCAACCCATCTCCTATCCGAGACCAATCTACCCCTTTCTTCTCGAGGCAATGTGTCACGGAGGACCGGGACCGATGGGTGGCTTTCAGCGTCCCGCATTCAGTTTTCTAGACTCACTGGAATCGAATTTGGATTTGCTCAAACGTAGCCGCCAGTACATGCCGACGAAGGCTTTTCATCAGACGGCTATGATGCCACCAGGGTTCGGTGTCGGAGGTGCTGGAGGAGGAAGACCGGGAGTACCCGGTGGTCCTGGTGGACCGGCGGCACCCGGGAAGGTGAAGGATCGGTACTCGTGTAAGTACTGTGGCAAAGTGTTCCCTCGGTCGGCTAACCTGACGCGACATCTGCGCACCCACACGGGTGAACAGCCGTACAAGTGTCGATACTGTGAGCGTTCCTTCAGCATCTCGAGCAACCTGCAGCGACACGTACGCAACATCCACAACAAAGAGCGCCCGTTTAAATGTCACCTGTGCGAGCGGTGCTTTGGACAGCAGACGAATCTGGATCGCCATCTGAAGAAGCATGATGCGGATGCGGCCGGGCTTGTGTTGGGTGATTCGCCCTCATCCAACGAAGCAGAACGAGGGGAGGATGTGTTCTTCGACGAGATTCGTTCATTTATGGGAAAGGTAACCTATTCGGGACCGGCATCCTTACTGACTGCGGGGACACTTCCGGCCGCTGCTGAAGTGGAAGCAGCCAAAGGTGAGGGAGAAGATGGCGAGAGTAGTGCGTCTGGTCGAAGGCGTTATGCGACACCGCTGGACGTTACTGGAGGTGACGATGATGAGGAAGAGGAAGAGGAAGATGAGGAGGAAGATGCAGCCAGCTGTGACGGTGAGAGTGATCTGATCAACATCGATTCGGACAAGGATACGATCAATAACAATGACACGATCGAGGTGTCTACTTAA
Protein Sequence: MRSKSVARRFAQGISGDESDASRGLPVNLEVPPGLQVVPMSKHHDHGPADFSLPTSLHHHLLPTADDVRERLKLQSAEQFLLQMARLQRPPPPDLDIQTGSVVALKTIPKGTQYGPFVGKLLREPMDRRFAWEVIDVDIRGWLDATLEPTNWMKHIRCTSSSGEANVQHFLKDGHLWYEVICDISPGRELLLRPKVPLHPRDGQDERSSERGSGGSQHSDNYEDEYNTSNDLDSSHNKEQHHHHNSSSSNSSGRSSNGSSTRANGHHPGDDSGNGSGEPHQHHHHSDVKEEDEDEHGIDARCVVCDRQCHDIDQLDDHLVISHHYPKDAYRCELCPRAYSYRPSLLRHRAIVHGELRRFPCENCPKNEDTDVSTATPNTSSSSELFSYLLQAHDNRVFTDPSNLQRHIRTHHVGARSHACPECGKTFATSSGLKQHTHIHSSVKPFQCEVCFKSYTQFSNLCRHRRMHADCQVQIKCNKCGDSFSTTTSLSKHKRFCDSTAVTRASLHSGAHPSHLRHPHDPYPHGRPHPGAGQQGTAGGTGGASAIAAGTGAGPLHTLPPGMATPPNPFLMFPGAPFFAPGFRPYPGMPGIFPPAPGQVPQFPLSFFPKPAAPGPLPEPERRTPSPSSRHLGLLESYGQQSMKISPPTGEEATNHLRPSPARPIPVSFNSAAAAVALLSGSPGPLMGNHNIPATESVQERGNNNNHIKENNNHNHTNGTSSYGGQTAQQQQQRRTSSRSSSVTAATTVKEELARDSSDTEEGDTGLSAIRVKNFSTRSKNASGETSKSPALSENRSQSHRRRSRTVEDGDTSESEEFSSEAKKAKKEEEASGSAEQPLDLSLSKKLKNDDVDDGVEADEDKDGSEEMVNRSSNRSPTPIEVTSPRSTPTPSVPTPNSSDVPHHDLSLRARGRNTTGSSISPKAASASPLADAFPLPSPSPSLSPRPSPSPSSPGGVTGSGPHHQPISYPRPIYPFLLEAMCHGGPGPMGGFQRPAFSFLDSLESNLDLLKRSRQYMPTKAFHQTAMMPPGFGVGGAGGGRPGVPGGPGGPAAPGKVKDRYSCKYCGKVFPRSANLTRHLRTHTGEQPYKCRYCERSFSISSNLQRHVRNIHNKERPFKCHLCERCFGQQTNLDRHLKKHDADAAGLVLGDSPSSNEAERGEDVFFDEIRSFMGKVTYSGPASLLTAGTLPAAAEVEAAKGEGEDGESSASGRRRYATPLDVTGGDDDEEEEEEDEEEDAASCDGESDLINIDSDKDTINNNDTIEVST

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00108550;
90% Identity: iTF_00108550; iTF_00105309;
80% Identity: -