Afun006004.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles funestus
Gene Symbol
Bcl11b
Assembly
None
Location
Contig1:90849035-90871642[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.00017 0.01 16.0 2.1 1 21 197 217 197 218 0.95
2 16 1.4e-06 8.6e-05 22.5 4.3 1 23 650 672 650 672 0.99
3 16 4.5e-07 2.7e-05 24.1 0.5 1 23 678 700 678 700 0.99
4 16 2.7e-05 0.0016 18.5 0.1 1 23 706 728 706 728 0.98
5 16 4.2e-05 0.0026 17.9 0.6 2 23 734 755 733 755 0.96
6 16 2.8e-07 1.7e-05 24.7 4.1 1 23 761 783 761 783 0.99
7 16 0.0001 0.0062 16.7 1.7 1 23 849 871 849 871 0.97
8 16 6.7e-06 0.00041 20.4 2.5 2 23 878 899 877 899 0.98
9 16 2.1e-06 0.00013 22.0 0.8 1 23 905 927 905 927 0.98
10 16 2.7e-06 0.00016 21.7 0.1 2 23 933 954 932 954 0.98
11 16 5.7e-07 3.5e-05 23.8 2.1 1 23 960 982 960 982 0.99
12 16 3.7e-07 2.2e-05 24.4 2.3 1 23 1029 1051 1029 1051 0.99
13 16 3.8e-07 2.3e-05 24.3 0.9 1 23 1057 1079 1057 1079 0.99
14 16 5.2e-05 0.0032 17.6 0.3 1 23 1085 1107 1085 1107 0.98
15 16 4.9e-06 0.0003 20.8 0.3 2 23 1113 1134 1112 1134 0.97
16 16 3.5e-06 0.00021 21.3 1.2 1 23 1140 1162 1140 1162 0.98

Sequence Information

Coding Sequence
ATGAAAGAAGCTCCAATGATCGACGCATTCGATACGGCGGATTTTAATCCGGAACTGATCCTGTCCAGTGTGTTTCTGGATCATGGACTAGATTTCGTTACCAACATCGACGATCTTGGTGACAATATCATTGCTTCCGATCTGCTGCAGCAGTTGGGCAGTTCGGTATTCTACACAGAGTCGCCTATTGCAACGAATGTCAACGGTGGTGGAAATGTTGGACTCTGTACCACCACTACACAGCACCATGCCCAAAATCAATTACCACCACAACAACAACAGCAGCAGCAGCAGCATCATCAACAACAGATTTTATCGCAACCATCACCAGCTCTTCTATCGGCCAAAGCGCGTATGACAATTGAGAAACCCACCGACGAGATGCGCTACGACACATTCGGAAGTGATTATGCAAAGCCACAACTTGTGCCGGCTGTGCCACTTCCGATGCCGACGGTGCAACAAATTCAACAGCAGCAGCAGCAGCAACAAACAGCACCGGTGGCTACACAGCAACAACAACCGTGCAAATGCGAATTCTGCGAGTATCTGCAAGCCAACCGAATATCGCTTACCGGCGATCACTCGTTTCAGTGCGAGTTCTGTGGAGAAGGCTTCTCCAATCAGACCAGCTTCAATCGGCATCGGTGTGGTAGCACGGATATACAGATATACCGGTGTGAAAACTGTCGTCAGGAGTATGGCAGCTCCCGTGCCGTTTCTAGCATTGGTAACTGTGAGCCAAGGGATAAATGCGATATCTGCAATCGGAACATTGTACAATCGTTGCCAGAAGAACAGGCCGCCTACGGGCCTGCAATGGTAGCAGGCAGTTCTTCGATATCCTCACAAACTACACCGGCATCGATGTCGGATGTCACGATCGATGGAACGGTTTCCCTGCTTGTTACTTCTCCAGAGGTGTCAAACGAAAGCGTCAGTGATCTCAGCGTTAACGTCAACGTAAGATCCATAGTGAACAGTCCCATCGAGCAGCACGATCTGAGTAGCATTGATCCGTTCGGATCAGACAGTGAATGTTTAGGTCAGTTCTTTGCTACCGAAGCGTCCTCAACTTCACCCTGTACGGCAAATACTACCAACAACATACAGTGTACACCAATGCCAACGAGTGCCAACATCGGGAGTCTTCTTCCAGCCACTACGCTGAACCATCCAGAGTCGGCGAAGACATACTTTGTGCTAGGAAACGTGGAACAACTGCAACAATTCCATGCAGCAGCAGCAGCAGCAGCAGCGTCATCAGCAACGGCACAACAACAGCAACCCACTAACAATCTTCCAACACTTCCGAATAGCTTCCATCCGCTTCATCTGCCACCTCCAGGACCTGGAGCTCATCAGCAACAGCAGCAACAGCTACCTCTCTCACTGCAGCACACTGTACCGGTTACGACCGCGTCACATCTGCCCAGTGAGCACGAGGTCACTAGTCTGCAGCAGTACGATCAGTACGATGATGAGGACTACTCGTCCATGTCCGAAGATGAAGCTATTGTTCCAATAGAACCCTATGCCAAATCACCTAATCAGGATCACGCCAAGACGGAACTTCCAATACAGGAGACAATCGTTGACACGAGCACCGGCATCAGTACGGTCATTCCGTTGCCGCCGTTCGGTTCTGGAGGATTGCCAAGAGATGATGCTTCACTCAGCCGAGCACTGTTGGTGGCGCATGTCGGTGGTCAGCATCTGCAGCTGCAGCAACAATCACAACAACAGCAACACCATCATCTCCACTCGTCCAGTGTATCACAGCTTAAGCCACATCTGGATGACGACGAAGAAGGCAAATGTGACTCCTCATCTCCATCCCTTGGTATATTCATCAACAGGTCCTCTGGAGTCTCGGAGAATGGAGTAGAGAAAGGGTCACAAAAAGCGCAGTCCTCCCTTGCAACCGGTTCCAATGTGGATCGGCCGTACAAGTGTCACATCTGCGAACGTTCGTACCGCAATCAGAAGAATCTGAAATCACATCTTAAAGTGCACGAAGGCATTCGGGCGTATCAATGTGAGATTTGTGGTAAGAATTTCTCCGGCTCGAGCTACCTGGTGATCCACCGACGGCGTCACACCGGTGAGCGACCATTTAAATGTGTCACCTGCGGCAAAGCGTTTGTGGACTCGCGTGCACTAGCGGTGCACGCGCGCTTACACAGCGGCGAACGGCTCAAGTGTGAAAAGTGTGAGAAAACTTTCTCCAGCGTGAGTGCCCTAACCGTGCACAACCGGCTGCACACCGGCATCCACCCGTACAAATGCGAACTGTGCGGTAAAACGTTTCCGCAGTACAACAACCTGAAGCACCACATGAAAAAGCACGAGCAACCGAATGGTGCGGAAAATCAGTCGCAAGTTACAGCGACGACCTCCCCGTGTGCGCCGGCAATGTCGAACGGGGTAAGCACAACGAGCGGTTCCGGCACTGTGCCGGGCCGGTTACGATCGCCGCCCGAAACGAAACTTCACGGTGCCGCACATATGGTGGCAAGTTCGACCACCGGATCACCGTTCGAGTACAAATGTCACATCTGCAGCAAGCTGTACAAATCCGCTGACGATCTGCAGGAACATCTGTCCCAGCACGGCAAAGATCGTCCGAATCAGTGCGAGTTTTGTTCGAAGGTGTTTCCCCGCTCGTCACATCTCATCATTCATCGGCGGCGGCATACGGGCGAGCGACCCTTCAAATGCAAATACTGCGACAAAGCGTTCGTCGACTCGCGGGCGCTCTCCGTCCACACGCGGCTTCACACGGGCGAACGGGTAAAGTGTGAGATCTGCGAGAAAACGTTCGCCAGTTCCAGCGGGCTCATAGTGCACCGGCGCATACACACCGGGGTGCATCCGTACAAGTGTGACTACTGTGACAAGTCTTTCGCCCAATCGACGGCACTCAAGTATCATCTGAAAAAGCATGATACAGCGCTGCTACCCACCACGACGACGCCGGAAAGTGTCGACTCACGGCTTTCAACGCGACCCCAGCACGGTACGGCCGATCTAGGCCAGTGTTCCGCGTACGGCGATGATCCACCGGTGGACGGGAACGATCGGTACAAGTGCACCGTCTGCAGCAAGGTGTTCCGTTCGTCCGAGTACCTGGTGCGTCATCGGCGGACGCACAGCGGGGAACGCCCGTACCAGTGTGAGATTTGTGGCAAAAACTTCTCCACCATGAGTTACCTGGTGATCCACCGGCGCCGGCACACGTCCGAACGGCCGTACAAGTGTACTTCCTGCGAGAAAGCATTCGTCGATTCGCGCGCACTGCAGGAACACGCCCGGCTACATACGGGCGATCGGGTCCGGTGCGAGATTTGCCAAAAGACCTACTCGAGCGTTAGCAACCTGATCGTGCACCGGCGCATCCACAGCGGCATCCATCCGTTCGAGTGTGACAGCTGCGGGAAATCGTTTGCCCAAAAAAATGCCCTCAAGTATCACCTCAAGAAGCACAGCAAACAGGATCAAACAGAGCCAATCGGTTAG
Protein Sequence
MKEAPMIDAFDTADFNPELILSSVFLDHGLDFVTNIDDLGDNIIASDLLQQLGSSVFYTESPIATNVNGGGNVGLCTTTTQHHAQNQLPPQQQQQQQQHHQQQILSQPSPALLSAKARMTIEKPTDEMRYDTFGSDYAKPQLVPAVPLPMPTVQQIQQQQQQQQTAPVATQQQQPCKCEFCEYLQANRISLTGDHSFQCEFCGEGFSNQTSFNRHRCGSTDIQIYRCENCRQEYGSSRAVSSIGNCEPRDKCDICNRNIVQSLPEEQAAYGPAMVAGSSSISSQTTPASMSDVTIDGTVSLLVTSPEVSNESVSDLSVNVNVRSIVNSPIEQHDLSSIDPFGSDSECLGQFFATEASSTSPCTANTTNNIQCTPMPTSANIGSLLPATTLNHPESAKTYFVLGNVEQLQQFHAAAAAAAASSATAQQQQPTNNLPTLPNSFHPLHLPPPGPGAHQQQQQQLPLSLQHTVPVTTASHLPSEHEVTSLQQYDQYDDEDYSSMSEDEAIVPIEPYAKSPNQDHAKTELPIQETIVDTSTGISTVIPLPPFGSGGLPRDDASLSRALLVAHVGGQHLQLQQQSQQQQHHHLHSSSVSQLKPHLDDDEEGKCDSSSPSLGIFINRSSGVSENGVEKGSQKAQSSLATGSNVDRPYKCHICERSYRNQKNLKSHLKVHEGIRAYQCEICGKNFSGSSYLVIHRRRHTGERPFKCVTCGKAFVDSRALAVHARLHSGERLKCEKCEKTFSSVSALTVHNRLHTGIHPYKCELCGKTFPQYNNLKHHMKKHEQPNGAENQSQVTATTSPCAPAMSNGVSTTSGSGTVPGRLRSPPETKLHGAAHMVASSTTGSPFEYKCHICSKLYKSADDLQEHLSQHGKDRPNQCEFCSKVFPRSSHLIIHRRRHTGERPFKCKYCDKAFVDSRALSVHTRLHTGERVKCEICEKTFASSSGLIVHRRIHTGVHPYKCDYCDKSFAQSTALKYHLKKHDTALLPTTTTPESVDSRLSTRPQHGTADLGQCSAYGDDPPVDGNDRYKCTVCSKVFRSSEYLVRHRRTHSGERPYQCEICGKNFSTMSYLVIHRRRHTSERPYKCTSCEKAFVDSRALQEHARLHTGDRVRCEICQKTYSSVSNLIVHRRIHSGIHPFECDSCGKSFAQKNALKYHLKKHSKQDQTEPIG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00105277;
90% Identity
-
80% Identity
-