Afun005966.1
Basic Information
- Insect
- Anopheles funestus
- Gene Symbol
- Hr39
- Assembly
- None
- Location
- Contig1:95354722-95358010[-]
Transcription Factor Domain
- TF Family
- SF-like
- Domain
- zf-C4|SF-like
- PFAM
- AnimalTFDB
- TF Group
- Zinc-Coordinating Group
- Description
- The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 0.058 4.3e+02 -0.2 0.5 123 165 51 91 40 167 0.64 2 4 0.17 1.2e+03 -1.7 0.8 67 82 391 406 352 500 0.51 3 4 3.8e-08 0.00028 20.1 0.0 1 20 589 608 589 614 0.93 4 4 4.5e-79 3.3e-75 253.7 0.0 157 408 690 951 675 951 0.92
Sequence Information
- Coding Sequence
- ATGAGAATTATGACATCGACCGAGATAAACGGAGGCGGTGGTACACCTGTGACGACACGCGGAGGAAACGTGTCCGTGACGACGATCAACTGTGACGATGGCGGTATGAGCGGATTGCCGCTGGACGTGAGCGGTGTTGTGGCGGCGATCAAACACAACAACAATAATAACAGCCTCAACAACAATAACAACAACAGCAGCAGCAGCAACATGTCGAGCAGTAATAATGTGAACAATAATAGCAGCTCTAGTGCAACTGCGACGACTGCTACGGGTAGTAGTTCCGGTGGCAGTCCGGTAGCGATGTCGACCGGTGGCATCTTTGGAAACGTGAGCGGTGGAATACGCATCACCGTGCCGAAGATGGAAGAGTCGGATGAGTCCGATACGGAGTTGTCCAACATTGAGAAGACAGCCGCAGCAGCACTAACGAACGGTGTTAATATGCGCGAGGAACGTAGCGCCAGTAAGAGCCTTCCGCGACCAATGTCCTGGGAGGGCGAACTGTCAGAACCGGAGGAACCGATGCTGGTGGACAACGAAAATTCGAGCTCGAGTTCGAACGGCGCTGGTAAGCTGATGATCGCCCCGATCGATCCGTCTCCGATCGCTATGATAGTGCCCAAGCGGGAAGAAGAGCTTGACATCGAACCACCTACGTCCGGGCCGGGTATTACGGAACCGTTAGCACTCACCGCTTCCAGCAGTAGTAGCAGTAGCAGCAGTAACAGTACCGTCGGTTGTTACAACCTTTCCTCCCATGGAAATAGTCAGGGTGGGGGAACGATAAGAAATCCGCACAGCAGCAGCAACACCGGTAGTAGCAGCTCCAGTAACTCACCGTTACCGAATCGGCTGATGATCAAACCGGAAGCGGGGCTTCCGCTGATCAATCCTGGACTAGCGTACAACGTATCCAGTCTCGGTAACTCCACCAACATTCCAACGTCTTCGGCGGCCGGAACATCGGCGATGAAGAAGGGACTGCCGGATGTGATAAATCTAAAGTACGAACTACCGCCGGGCGGTGTGGGCGATCCGGGCGGTGGAGGGAACGCACTGCCACCAAGTGCGATCCATTCGCCGCTGCTGGTACGCTCGAAGACTACTCTACTGCCCGCGAATCCCAGCCCCGATTCAGCCATCCACTCGGTGTACACGCACAGTTCGCCGAGCCAATCGCCACTTACATCCCGCCATGCACCGTACACGCCATCGCTTAGCCGAAACAATAGTGACGCGTCACACAGCAGCTGCTATTCGTACAGCTCCGAGTTTAGTCCGACACACTCGCCTATCCAGGGCCGGCACAATATATTCGCCAGCGGTGGTGGTGGAGGGAGTGGAGGCAGCGGGGGAGGTAGTGCGTCGTTCAATGGGTCACCGTTGCATCACTCAGTATTATACAAACCGATGCTGGACAGCGAGCAGCAGCAGCAGCAGGCCCTCAAACAGTTGGCAGCAGCAGCAGCGGCAGCCGCCCAGGAGGAACCCCTCTACGAAGGGGACCATTTGCCTTCGCCTGGTATATCTCGGCAGCAGCTTATCAACAGTCCATGTCCCATTTGCGGCGATAAGATATCCGGCTTCCATTATGGCATTTTCTCGTGCGAGTCGTGCAAGGGCTTCTTCAAGCGTACGGTGCAGAACCGTAAGAACTACGTGTGCCTTAGGGGGGCGGCCTGTCCGGTGACGATAGCGACACGCAAAAAGTGTCCCGCCTGCCGTTTCGAGAAGTGCCTTCAGAAGGGAATGAAGCTGGAAGCTATTCGGGAGGATCGAACACGTGGAGGACGCTCGACATACCAGTGCTCATACACCTTGCCAGGACCGTTGGTAAACGCAGGCGGTGGAATGCAAACGGGTGACTCTCCAGGAGCGGGACCGTTCCAGTACGGTGGAACGGTACGGTCACCGTACGTTGGAGGAGGTCCAGGAGTTGGCGGAGGTCAACAAATGAAGATGGAACCACCGGACGGTGGTATGATGATGGTCGGATCGGGATCCATTGGTGGAAGTAGCGGTGTAATGAACGGAATAGGCAACGGACCCGGTTCGGACGGTGGCAGCAGCTCCAGTGGAGCTAATCACATGCAACCAGGCATTCCAGTACTGTTACAGGAAATTATGGACGTTGAACCCCTGTGGCAGTATAATGCACAGGAACTGGCCCGACTCAACCAACCCGCAACGAACGTAAGCAGCACAACGATCGCCAACAACCCGATCCTTTCCAGTGCCGGCATCTCGTCCGACAGCAGCCCCGATCTGATCGCTAACCTCTGTAACATTGCCGACCACCGACTGTACAAGATTGTCAAGTGGTGCAAAAGTCTGCCACTATTTAAGCACATTTCCATCGATGATCAGATCTGTCTGCTGATCAATTCCTGGTGTGAGCTGTTGCTGTTTTCATGCTGCTACCGTTCGATCTCGACACCGGGTGAGATTAAAATTTCTCTCGGCAAGTCGATCACGTTGGAACAGGTTAAGAATAGTGGTTTGCAGACGTGTATTGAACGGATGTTAAATCTAACTGATCACTTACGACGATTGCGTGTCGATCGGTACGAGTACGTTGCGATGAAGGTGATCGTGTTGCTCTCTTCGGACACTTCCGAACTGAAGGAATCAGAAAAGGTGCGGACAAGCCAGGAGAAGGCATTGCAGGCACTGCAAGCCTATACACTGGCCCATTATCCCAAGTCACCGGCCAAGTTTGGCGAGCTACTGTTGCGTATTCCCGAGCTACAGCGCACATGTCAGGTTGGTAAGGAAATGCTCACAATTAAACCGAAAGATGGCGAAGAACCTTCGTTTAATCTGCTAATGGAACTGCTCCGTGGAGAGCACTGA
- Protein Sequence
- MRIMTSTEINGGGGTPVTTRGGNVSVTTINCDDGGMSGLPLDVSGVVAAIKHNNNNNSLNNNNNNSSSSNMSSSNNVNNNSSSSATATTATGSSSGGSPVAMSTGGIFGNVSGGIRITVPKMEESDESDTELSNIEKTAAAALTNGVNMREERSASKSLPRPMSWEGELSEPEEPMLVDNENSSSSSNGAGKLMIAPIDPSPIAMIVPKREEELDIEPPTSGPGITEPLALTASSSSSSSSSNSTVGCYNLSSHGNSQGGGTIRNPHSSSNTGSSSSSNSPLPNRLMIKPEAGLPLINPGLAYNVSSLGNSTNIPTSSAAGTSAMKKGLPDVINLKYELPPGGVGDPGGGGNALPPSAIHSPLLVRSKTTLLPANPSPDSAIHSVYTHSSPSQSPLTSRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPIQGRHNIFASGGGGGSGGSGGGSASFNGSPLHHSVLYKPMLDSEQQQQQALKQLAAAAAAAAQEEPLYEGDHLPSPGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCLRGAACPVTIATRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPGPLVNAGGGMQTGDSPGAGPFQYGGTVRSPYVGGGPGVGGGQQMKMEPPDGGMMMVGSGSIGGSSGVMNGIGNGPGSDGGSSSSGANHMQPGIPVLLQEIMDVEPLWQYNAQELARLNQPATNVSSTTIANNPILSSAGISSDSSPDLIANLCNIADHRLYKIVKWCKSLPLFKHISIDDQICLLINSWCELLLFSCCYRSISTPGEIKISLGKSITLEQVKNSGLQTCIERMLNLTDHLRRLRVDRYEYVAMKVIVLLSSDTSELKESEKVRTSQEKALQALQAYTLAHYPKSPAKFGELLLRIPELQRTCQVGKEMLTIKPKDGEEPSFNLLMELLRGEH
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00097815;
- 90% Identity
- iTF_00097815;
- 80% Identity
- iTF_00101733;