Basic Information

Gene Symbol
klhl22
Assembly
GCA_000473445.2
Location
KI915047.1:3420965-3425075[+]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 0.12 27 4.5 0.0 5 30 162 187 158 193 0.86
2 3 0.76 1.6e+02 2.0 0.0 56 106 396 449 386 453 0.79
3 3 1.7e-15 3.6e-13 49.2 0.0 21 108 850 938 845 940 0.91

Sequence Information

Coding Sequence
ATGACGGCACACGAATCGTACGGCTTCATCGGGACGTGGGAGATTGTGGAGTCACACCTGGAGGGAACCACCGAGAAGCTAGGTCTCGAGGGCATCAAGTTCCGGCTGGACGAGATGGGCGACATCATCTGGTACAACGATCTGATCCACATGACGAACGGGCAGTCGAATGGGGCGCGCGAGCTGAGCCCCCGGTCGCTCGGCAGCCTGGACGGGCCGGCCGCGACCACCTTCTGCCCGATCAACGACTCCGCCGCCGTGCTGTTCAGCTGCGAAACGTTCGAGGTGGTGGAGCTGAGCTCGAACGGGCCGGGGCTGATCTTCGGCGCGTACACCGGCCACAGCATCGAGTTCCGGACGAACCACTACAACCCGGGCGAGCAGATGTCGCTCCGGTGCGACTGCTGGTGCGAGCTGCACTGTCAGCGCGTGAAGGAGGACCAGTCGGTCGGGCAGGAGGAACCGTTCACGCTGCGCACCGTGCTGGACGATGGCAACTTCTGTGATGTGACTCTCAAGAGTTGTGATAACGTAATCTACAACGTGCACTCGCCGATCCTACGACTGAACGGATTCGATTGCAGCAGTATGACGGCTGCCTCCACCTACCAGCATCTGGCGAGCCGGTTTGAGTGTGCCGAGGCGCAGGCACAGGTCGCCCAGGCGAGCCATCCGCCGCTGATGAAGGTTTCGTCCGTACCGTGCGCAAGGTCGTCGCCGAGGGCGGGTGTCACCGTGACCGCCGGTGGCCTCCGGGGGCTTCCCGTCATGTGCAGTGTGAGTGCGAGCGCCACGCCCAGCCTACACGCGTCCGTCAGCCCGACGATACTCAACCCGAACTTCCTGCTACCACCGGCCGCCCTCGATACCCCGTACGGGCTCTCCCCGAAGCTGGCGGCCGTCGCCAACATATCCAACTCCTTCAACTGTCTCGTCCCGACGGCGGACCGGCCGTGCGCCGCTGGGTCCATCTTTCTCGACGTACCGCCCCGCCGCCAAACGTCCGTCTCCTGCTCGGACGTGTTCTACTTCCCGGAGGCGGCACCGCCGCCGCCCGCATCACCGGCCGGGCGCGTCAAGTTCAAAGCCCCACCGGCGTCCCCGTTCCGGGCGCGCAGCCCGTCGCCGTTCCCGGTCGCGACGCTCGACACGCCGCCGTCCTCGCCGCTGACGCCGCTCTCGGTGCTGAACAACATCCCGGCCCGGATGCTGTCCACGATCCTGCACTGGCTGTACTGCGAGTGCCTGCCCGAGCAGCTGGACGAGGAGACGTGCATACAGCTGCTCAACATGTGCGAAAGCACGACCCCGCTCAGCCGGATGAGCGAACCCTGCAAGAACTACCTACGGAACATCCAGCTCAAGAAGTTTGTAATCGACATCATCAACGACCTGCACGATAGTCTGAACAACATGATCCAGATGGTCAACCCGAACACGATCTCGCACAGCCCGTGCGTCCTCTGTCAGGTGTTTAAGGAGGGCGTGAAGGAATGTCTCACCGCGTTCGTGAAGCTGCTCCAGTTTTGCAACATTTTCACGAAGGACGCGACGACCTTTACCCGCCAGCAGCGGCACGAAATCATCAAGTACGTGCGGACCCGCATGCCGATCTATCTCTCCCAGATCCACCAGCTGCTGCAGAACGTGCACCTCGTGCTGGGCAGCCTGACGCCCGACGACCGGAACGATCTCGTCTCGTACCTCGTGCCGGAGATCACCGGTGCGCTCGAGGTGCTGACGTCCGCCGTGTCCGAGATCAAGGTTTCGCTCGAGAAGTCCGACCTGAAGTTCTTCCTGTACATGTACGAGGTGAAAAAGATGCGCGACATCTACGGGCGCGTGACGAACGCGCTCGAGGTGCTGCTGCACAAGAAGGGCACCTTCAACGAGATGAACCTGCTGCACCAGCACCAGACGGTGCGGCGCAACCTGGAGCAGCTCGCGCTGGAGGTACCGGCCGCGATCGGCCAGCTCGAGGAGCTCTGCGACACGATCGACGAGAAGATCGGCTGGAAGGAGTTTAAGTTTTGCTTCAAGTTTCTCACCAGCCAGGTGAACGGAATCGTTTCGAAGCTGCTGGAGCACAAGGCCGCACTGAACGAGGCGATGCTGTTTATTTCGAACCTGGTGCAGAAAGATCCGTTCACGGGTGCGCTCGTCGAGCTGGGTTTGCTCGATCGGCACAGCGTGGATCCGGCCCTGCTGCACGAGTGTGCCCAGCGGCGCAGCGCGGTACGTTCGAGCGGGCAGCGGCAGCTCGAGTACGCGACGGTGAAGGTGAACCTGGTGCAGAACCTGTGCGAATCACCGACCGCCGCCCACAGCAGCCTGTCGAAGAACGCCCTGAAGCTGCTGCACTCGGGCCAGCTGGCGGATATGGAGTTCGAGGTGATCGTACCGAGCGCGGAACAGCACCAGAACGTGGCACCGGCATCGTTCGACTTCAGCCCGGACGAGGGTTCGCTGCTTAATGGTGCCCTGGAGCGGGGCGGCGGACCTGGCACCGACACGAAAGGTGGCGCAGCGGGGAAGGGCACACAGTCGCACTGCTTCAAGGCGCACCGGGTGATAGTGGCGGCACGGTGCGAGTGGTTCCGGAAGGCGCTGCTGTCCGGCATGCAGGAGGACATCAATCGCAAGATCATCATCTACGACACGTCGCCGGTCATCTTCCGCCGGTTGCTGCTGTATCTGTACGGTGCGCCCGTCGACAAGTCGGTCGGGGTCGATCAGCTGTGCGAGCTGATGCTGCTCGCCGATCGCTACTCGGTCGACAACCTGAAGGCGATCTGCGAGCAGACGCTCGTGGCCTCGATCGACAACGACTCGGTCATCTGTCTGTACGGCATCTCGGATCGGTTCAACGCGGCGGCGCTCAAGGCGCGCTGTCTCTCCTACCTGTCGCAGCATACCGAGCTGACGCAGCTGGACATCTTCCAGGAGCTGCCGGTTTACCTGCAGAACGAGGTGCAGGAGCTGATACACTGGTGCGGGCGGGCACCGGAACCATGGTGTGACCGCGGGACGGAGCGTTCCCGCTCGGATCGCGGCTCACGCCACAGTCTCAAGAGCCCGTCGAAGGCAGCTTCCAAGTCGTCCCGGTCGCGCAAAACGTCACCCTCCTTCATGTGA
Protein Sequence
MTAHESYGFIGTWEIVESHLEGTTEKLGLEGIKFRLDEMGDIIWYNDLIHMTNGQSNGARELSPRSLGSLDGPAATTFCPINDSAAVLFSCETFEVVELSSNGPGLIFGAYTGHSIEFRTNHYNPGEQMSLRCDCWCELHCQRVKEDQSVGQEEPFTLRTVLDDGNFCDVTLKSCDNVIYNVHSPILRLNGFDCSSMTAASTYQHLASRFECAEAQAQVAQASHPPLMKVSSVPCARSSPRAGVTVTAGGLRGLPVMCSVSASATPSLHASVSPTILNPNFLLPPAALDTPYGLSPKLAAVANISNSFNCLVPTADRPCAAGSIFLDVPPRRQTSVSCSDVFYFPEAAPPPPASPAGRVKFKAPPASPFRARSPSPFPVATLDTPPSSPLTPLSVLNNIPARMLSTILHWLYCECLPEQLDEETCIQLLNMCESTTPLSRMSEPCKNYLRNIQLKKFVIDIINDLHDSLNNMIQMVNPNTISHSPCVLCQVFKEGVKECLTAFVKLLQFCNIFTKDATTFTRQQRHEIIKYVRTRMPIYLSQIHQLLQNVHLVLGSLTPDDRNDLVSYLVPEITGALEVLTSAVSEIKVSLEKSDLKFFLYMYEVKKMRDIYGRVTNALEVLLHKKGTFNEMNLLHQHQTVRRNLEQLALEVPAAIGQLEELCDTIDEKIGWKEFKFCFKFLTSQVNGIVSKLLEHKAALNEAMLFISNLVQKDPFTGALVELGLLDRHSVDPALLHECAQRRSAVRSSGQRQLEYATVKVNLVQNLCESPTAAHSSLSKNALKLLHSGQLADMEFEVIVPSAEQHQNVAPASFDFSPDEGSLLNGALERGGGPGTDTKGGAAGKGTQSHCFKAHRVIVAARCEWFRKALLSGMQEDINRKIIIYDTSPVIFRRLLLYLYGAPVDKSVGVDQLCELMLLADRYSVDNLKAICEQTLVASIDNDSVICLYGISDRFNAAALKARCLSYLSQHTELTQLDIFQELPVYLQNEVQELIHWCGRAPEPWCDRGTERSRSDRGSRHSLKSPSKAASKSSRSRKTSPSFM

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00106496;
90% Identity
iTF_00106496;
80% Identity
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