Afar004078.1
Basic Information
- Insect
- Anopheles farauti
- Gene Symbol
- RHOBTB1
- Assembly
- GCA_000473445.2
- Location
- KI915041.1:12188367-12196034[+]
Transcription Factor Domain
- TF Family
- BTB
- Domain
- zf-C2H2|ZBTB
- PFAM
- PF00651
- TF Group
- Zinc-Coordinating Group
- Description
- The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 3 6.4 1.4e+03 -1.0 0.2 28 44 262 278 256 299 0.76 2 3 1.4e-07 3e-05 23.7 0.1 46 104 372 429 354 435 0.85 3 3 1.1e-17 2.5e-15 56.2 0.0 6 103 459 555 455 562 0.92
Sequence Information
- Coding Sequence
- ATGGACAACGAACAGCCACACCAGGAGCTGGTAAAGTGTGTCCTCGTGGGTGATACGGCCGTCGGCAAGACGCGGTTAATCTGCGCCCGGGCCTGCAACAAGCACGTCTCGCTCTCCCAGCTGCTCAACACGCATGTGCCAACCGTCTTCGCCATTGACCAGTACCGGATCTACAAGGATGTCCTCGAACGATCGTGGGAAATTGTGGATGGAGTTAACGTCTCACTGCGGCTGTGGGATACCTTCGGCGATCATGACAAGGATCGACGGTTCGCGTACGGTCGGTCGGACGTGGTGCTGCTGTGCTTTTCGATCGCGAATCCCGTCTCGCTGCGGAACTGCCGGGCGATGTGGTACCCAGAGATCCGGAAGTTCTGCCCGGATACGCCCGTGATACTGGTGGGATGCAAGAACGACCTGCGGTATATGTACCGCGACGAAACCTACCTGTCCTACTTCGGCGAACGGAGCCCGTTCGTGCGGGCCGCCCGCAAGTCCGACCTGGTGATGCCGGACGAGGCGCGCGCGGTCGCGAAGGAGCTGGGCGTCGCCTACTACGAGACGAGCGTGTTCACGTACTTCGGCGTGAACGAGGTGTTTGAGAACGCGATCCGGGCGGCACTGATTGCGCGCCGGGAGCATCGCTTCTGGATGACCAATCTGAAGCGTGTTCAGCGGCCGCTACTACAGGCCCCCTTCCGACCGCCGAAACCACCGCCGCCGGAAGTAACCGTCATTACCGGCACGCATACGAAGGACATGCTTAACATGTTCAATTCCCAATTTATGTTAGCTAGTAGTTCGAATGCATTTCATAGGTTACTAATGATGGACATCAGCGACATTGGTGCGCGCAGCAGCAGCGAGTCCAGTATGGTCAGCTCGACGTTCGGTGAATCGACGACGGCCGACTTCAACGAGGACACGGAGTGTTTAATACGCCTCGAGCAGAACAAAGTGGCTCCAAACCGAATGTGGGAGCAACTCAAACGACGTTCCAGCTATCAGGCGCTGCCGACGGTGGAACCGAAGAAAGATCTCTATCGGGAGCTGCATCATCCCGTGTTTCAAAGTATTAGAGTGTTCCAGATTGACAGCGGCAGGCACAGCTACACGCAAACGCAGACGGTCGTGCAGATCAGCAAGGTGATCACACCGCAAGCGATGCAGCAGTGCCTGAAGTTCATCTACACCGGCACTATTGATCGCGATTGCCTCGATCTGCAGGAAATACGACAAGCGGCCGAGTTCCTGGAGCTTCCTCAGCTGATGGTGCTGTTGTCCAACACGCAAGCAAATCAAAGCTTCATGAACGATGAAACCATCCAACACTACTCGACGTGCATGAAACAAAATCTGGAGAAATATTGTGTTCAGAACGGTATCTTCGGTGATATCACGTTCGAGCTGGACGATGGCCACATGAAGGCGCATCGTGCCATGCTGGTGGCGCGCTGTGATGTGATGAAGGCGATGCTGAACGGCGACTTCCGTGAGGCGCACGCCAATCTGATCGTACTTCCCGGTGTGACGGAATACACCTTCCACAAGCTGCTGTGCTATCTGTACACGGACGAAATACCGCCCATCTCGGCGGACAAGTGTCTCAACCTGCTGGAGCTCGCCAATCGGCTCTGTCTGCCGCGGTTGCTGAATTTGGTCGAGTGTCGCGTGATCGAGGACCTGCTGCGGATGTCCCAGAATGAGACGAGCGAAGCGGTCGAGCACTGCCTGCGGCTGCTGGAACCGGTGAAGCTCCACAACGCTCACCAGCTGGCGGAATGGTGCATGTCGTACCTGTGCGTCAACTACAACAGCATCTGCCGGCTGTCCCCGCGCAGCCTGAAGGGCCTCCACCCGGACAATCAGGACTATCTGCGCGAGCACCGCTGGCCGCCGGTTTGGTATCTGAAGGACTACGACTACTACCAGCGCTGCATGAACGAGCTCAGCCGGGAGCTGAACAGTGGCAAAAAAGACTGCACCGCAGACGACAAGGGGTGTCTGTGCTTCTCCGGAGGGAAATCGAAACGTTCGGCTGCGACGGCCAAATCGGCCATCCAGGCGTCCGGCAAGGGTGGTCAGGCGACCGGTGGGTCCGGCGCTGCCGGCAACGATCAGCAGGACGCGGTCAGTACGAGTCTCTTCCAATCGAACGCCAACTCGGTCAACCAGCTCGATCCGGAACACGATGCCGGTGACCTTTGA
- Protein Sequence
- MDNEQPHQELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLNTHVPTVFAIDQYRIYKDVLERSWEIVDGVNVSLRLWDTFGDHDKDRRFAYGRSDVVLLCFSIANPVSLRNCRAMWYPEIRKFCPDTPVILVGCKNDLRYMYRDETYLSYFGERSPFVRAARKSDLVMPDEARAVAKELGVAYYETSVFTYFGVNEVFENAIRAALIARREHRFWMTNLKRVQRPLLQAPFRPPKPPPPEVTVITGTHTKDMLNMFNSQFMLASSSNAFHRLLMMDISDIGARSSSESSMVSSTFGESTTADFNEDTECLIRLEQNKVAPNRMWEQLKRRSSYQALPTVEPKKDLYRELHHPVFQSIRVFQIDSGRHSYTQTQTVVQISKVITPQAMQQCLKFIYTGTIDRDCLDLQEIRQAAEFLELPQLMVLLSNTQANQSFMNDETIQHYSTCMKQNLEKYCVQNGIFGDITFELDDGHMKAHRAMLVARCDVMKAMLNGDFREAHANLIVLPGVTEYTFHKLLCYLYTDEIPPISADKCLNLLELANRLCLPRLLNLVECRVIEDLLRMSQNETSEAVEHCLRLLEPVKLHNAHQLAEWCMSYLCVNYNSICRLSPRSLKGLHPDNQDYLREHRWPPVWYLKDYDYYQRCMNELSRELNSGKKDCTADDKGCLCFSGGKSKRSAATAKSAIQASGKGGQATGGSGAAGNDQQDAVSTSLFQSNANSVNQLDPEHDAGDL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01164072;
- 90% Identity
- iTF_00400693;
- 80% Identity
- -