Basic Information

Insect: Anopheles epiroticus
Gene Symbol: foxo
Assembly: GCA_000349105.1
Location: KB671509:1287046-1333593[-]

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3e-28 1.9e-25 88.1 0.3 4 84 35 117 33 120 0.92

2 2 4.2 2.7e+03 -2.1 0.0 3 21 350 369 348 395 0.66

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3e-28	1.9e-25	88.1	0.3	4	84	35	117	33	120	0.92
2	2	4.2	2.7e+03	-2.1	0.0	3	21	350	369	348	395	0.66

Sequence Information

Coding Sequence: ATGTTAAGTTCTAAACTCTTAAGGTCCAGTAGCACACAGCTGCAGGCGGCCGCATCCTCGTCCTCGTCGAAGAAGAACTCATCGCGGCGTAACGCCTGGGGCAATCTGTCGTACGCCGACCTCATCACACAAGCCATCAGCTCGGCCAGCGATAGCCGACTAACGCTCAGCCAGATCTACGAGTGGATGGTGCAGAATGTGCCGTACTTCAAGGATAAGGGCGACTCGAACAGCAGCGCCGGCTGGAAGAACTCGATCCGACACAATTTATCGCTGCACAATCGCTTCATGCGAGTACAGAACGAGGGTACGGGCAAGTCGTCCTGGTGGATGCTGAACCCGGACGCTAAGCCGGGCAAGTCGGTGCGCCGGCGGGCCGCCTCGATGGAAACGTCCAAGTACGAGAAGCGCCGGGGCCGGGCGAAAAAGCGCGTCGAAGCGATCCGGCAGCAGGCAGCCCTCGGTCTGGCCACAAACCCGCTGAACGATGCCACCCCGTCGCCGAGCAGTAGCGTTAGTGAAGGATTAGATCTGTTTCCGGAGAGTCCACTGCATAGCGGTAACTTCCAGCTGTCGCCCGACTTCCGCCAGCGTGCCTCCTCGAACGCGAGCTCGTGCGGTAGGTTAAGCCCGATCCAGTCGATCGTGGGCGTTGAGAACACGTGGAACTATACGGCGGCGGACGTGGCCGATCTGGTCGACAGTGCCGACCAGGCGCAGGGTGACGTGCTCGAGCTGGACATCGGTACGCTCGATCAGCTGGCCGGTTCGTTGGCGGACGAGCTGACACTGCAGCAGACCGATTACTTCAAAGGATTCACCCATTCGACGGCGATGCACAATCAGCCGCCACCGCCACCGTACCAGCCGCCCCAGCCCTTCTCGCTGATGGCCTCGGTCGCCCCGTCCTACGGTCTCCCGCAGCAACAGAATCAGTGCCCGATTCATCGCATACAACATTGTACCTGCATGCTACAGAATAATGCTCGTGAGAGCATCTCACCGGCGTCCGGAACCGGCATGTCGCCCTCATATCCGCACAGCGAACCGTCACCTGACTACGCCATGCTAATTGGATCTCGCGTAATACAAAGAACGCCCTCGTCTAGTCCTCCGCTAACGCCAAATACAATCTGCGGATTGATagcgccaccaccgcagcagcagcagcagcagcaccaacagcagcagcaggATCCGACACCGCAGACGCTAATGGGTCAAGTGATGGAAGCTTTAAACAGCCAAACAAACATCGACGACATCAACATCAACGTGGAATCGTTTCCATGTGTGGACGAGGTGCTGAAGCACGAGCTGAGCCTGGAGGGATCGCTGGACTTCTCCAATCTGCCCCTGTCGATCCACAGCAGCTACGCGGCACCGAACAATTCCAACTCGTCCGACTCGTCGTCCGGGATCAGTGCGATGACCGCACCGACGTCGAACCAGCAGACGGCCGCCCACAACCACGGCCAGTACGCGGCCAGAACGAGCGTAACGCCACCGTCCTGGGTGCATTAG
Protein Sequence: MLSSKLLRSSSTQLQAAASSSSSKKNSSRRNAWGNLSYADLITQAISSASDSRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNSIRHNLSLHNRFMRVQNEGTGKSSWWMLNPDAKPGKSVRRRAASMETSKYEKRRGRAKKRVEAIRQQAALGLATNPLNDATPSPSSSVSEGLDLFPESPLHSGNFQLSPDFRQRASSNASSCGRLSPIQSIVGVENTWNYTAADVADLVDSADQAQGDVLELDIGTLDQLAGSLADELTLQQTDYFKGFTHSTAMHNQPPPPPYQPPQPFSLMASVAPSYGLPQQQNQCPIHRIQHCTCMLQNNARESISPASGTGMSPSYPHSEPSPDYAMLIGSRVIQRTPSSSPPLTPNTICGLIAPPPQQQQQQHQQQQQDPTPQTLMGQVMEALNSQTNIDDININVESFPCVDEVLKHELSLEGSLDFSNLPLSIHSSYAAPNNSNSSDSSSGISAMTAPTSNQQTAAHNHGQYAARTSVTPPSWVH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00104975;
90% Identity: iTF_00100808;
80% Identity: -