Basic Information

Gene Symbol
thap1
Assembly
GCA_000349145.1
Location
KB673423.1:1398978-1407289[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.51 29 4.9 0.0 2 12 156 166 155 169 0.89
2 9 0.46 26 5.0 0.4 3 19 478 494 476 496 0.87
3 9 0.33 19 5.5 1.7 3 21 509 527 509 528 0.92
4 9 5.7e-08 3.2e-06 26.8 0.7 1 23 569 591 569 591 0.98
5 9 0.00048 0.027 14.4 0.9 1 21 599 619 599 620 0.95
6 9 0.0023 0.13 12.3 0.6 1 19 680 698 680 702 0.94
7 9 2.9e-07 1.6e-05 24.5 0.3 1 23 708 730 708 730 0.98
8 9 1.4e-06 7.9e-05 22.4 0.3 1 23 736 759 736 759 0.96
9 9 1.6 92 3.3 0.1 1 17 765 781 765 782 0.82

Sequence Information

Coding Sequence
ATGCCTGCATCATGCATTATATCGGATTGCAATttgaaatacacacacagcgaagaTGTATCGTTCCACAAATTTCCGCTCAAAAACCCAGACCTCCTAACGCAATGGATGCAGTTTGCTGGCCGTGATGAGGATTGGCGTCCTACCAAATGGAGTGCAATATGTAGCAGACATTTCGTGGCAAGCGACTTCAAAGACTGTCCCTTTCGAAAGATACTTCTGCCGACGGCCGTACCTTCTGTGCGTACGATCACATCTAAATTTCACCCGTTAGACCTGTCCGCGCTGCCCGTTATATCGTACGAAACGGTTTGGTCCGAGGATGGACGTCCTCTGCCGCGTAACGAGGACTATGTACCCGATGAACATGACACTTTTGCACAGAGCGCAACCCTCGTTACGGTTTCGGACGGTGGGGAAGAGCTCGGAATTGATGGTGAAGATGATGTGCTGTTAATACAGATAACCTGTCGGATCTGTGGAGTCGTTTTCAGTCGTGTCGCGGATAGCCTTCTGACGGATCTCGTGCAGTCGGAAGATGTGATAAGGAAGTACCTTCCCTTCGTGAACTTAGAACTGGAAAATTTGCCTCGGAAAATATGCCTAAACTGCTCGAAGGTGGTGAACGGGTTTTCGAAGTTTAGTGAAAGCGTCATTCGAGCCCAATCGGATCTGGAGCATCGATTTGCTCCACAACCTGCCACAACGAATgcaacaccaccacatccACTGCCAGTGGCGAGAACCAAACAAGAAAGCAACACCGGAAAGCCTATGAACATTAAGCAAGAACCGATCGCGAGTCTAAATATCAAAGAAGAGAAAATCGAATACGCACGCCAGAAAGACTGCTTCCCATTGGAGGATCCGATCGAAGGACCGGTGATAATTAAGAACCAGACGTTCGGTGGTGATCCAAAccgaatttatttatttaacaacatCCATCAGGATCTCGCCAATGGTACGACCAGTACTGCTGTGACGTCACAACAAAACCGCGAGCCTTCGAAGAACTGTGAAATACTTGAAATAGTGAATCTTTACCCCCCGATTGTGGACATTACCAGCGCAACGGTGACGGAGGTGCAACCGTACGAGATCACACTACCATCGGTCACCACGGCAACCACTTCCGAAGCGTTCTCATCTTTACGTACCACATCCGCTTATTCGGTGCAGTTGAAGGTGGAAAACAATACCGAATTGGACGCAGAACTGGACAAATATTATCTACCCGAAAAGCTCGGATTCATCAACACGCTGGAGGAGCACAGCTACACCAAACTTCCGATTCAGGCAGACGACAATAAGGATGAAATCTTCCATCATATGGTCATCGGTAGCCACGGCCAGTGGTTTGACAGTGCGAACGTGATTGTGGCCGCGAACAGCAAACCAACTCCGCAAAGAAATGCACGTCGTTGGGCATGCACCAACTGTGAACGACGCTTTGCCCGTCACCGGCGGATGATGTACCACCGGGTGTGGGAATGCCCCGGACGAAGGAAGCTTTCCGTGGGCTGTCAGTTTTGCCGTCGAAAATTTCGCTCCTGGTCGAGAGCACGAGCTCATGTGTGCATCTGTCCCAAACGAGCCCTCAGACATAGTAGGcttaaatggaaaatgggaTTAGAAAAGGTGAAACTAAGGCAAACGGATACGTCGAGAGTAGATGGTCAAGAGGAAGTGGTCATCACAAAATACCCCTGCTCGATGTGTGATAGATCGTACTCGAACGCATCCAATTTACGTCGGCATCTTTCCACACACCGACCTCAGGATCAATGGAACCACAAGTGTGGCGTTTGTTTCAAGGTGTTCGACAAGCTGTTTGATTTGAAGCGGCATCTACAAATCGCTTCCTGTGGCAATGGTGGCAATACAATCGCTGTGCAGGCCTCCGAAACGCAAGGCCAAGAAGTAGAGCTGCCATCGGTGCCACTGCATACTGTTCCGGAGGCACCACCACCCGCGGATGTTCTTGAAGGAACGTTAAATACCACGCCGCCAAGTACCAGCGTCGATCGGCTGCTGTACGTATGCTCGACCTGCAACAAAATGTTCCAGTCGTACAATAGCCTCAAAATGCACGAGCCAATCCACACTGGGGCGAAGACGTACATCTGCGAAACGTGCGGGAAACGTTTCTCCGGTCCCTCAAACCTGTGGCAGCACCGGCTCACCCACTCCGAGGTGCGGCAGTTCAACTGCAACCAGTGTCCGAAGGTGTTCAAACGGAAAGGCGGCCTCAGTCAACACATCCGCGCTATTCACATGAACATTAAGCCGTATCAATGCGCCACCTGCGGCCACGAGTACGCCCTTAAAGCAGATATGACGCGCTGCCGACACTCGCGCCTACACGAATCAGCGATTCCAGCGTGCTAG
Protein Sequence
MPASCIISDCNLKYTHSEDVSFHKFPLKNPDLLTQWMQFAGRDEDWRPTKWSAICSRHFVASDFKDCPFRKILLPTAVPSVRTITSKFHPLDLSALPVISYETVWSEDGRPLPRNEDYVPDEHDTFAQSATLVTVSDGGEELGIDGEDDVLLIQITCRICGVVFSRVADSLLTDLVQSEDVIRKYLPFVNLELENLPRKICLNCSKVVNGFSKFSESVIRAQSDLEHRFAPQPATTNATPPHPLPVARTKQESNTGKPMNIKQEPIASLNIKEEKIEYARQKDCFPLEDPIEGPVIIKNQTFGGDPNRIYLFNNIHQDLANGTTSTAVTSQQNREPSKNCEILEIVNLYPPIVDITSATVTEVQPYEITLPSVTTATTSEAFSSLRTTSAYSVQLKVENNTELDAELDKYYLPEKLGFINTLEEHSYTKLPIQADDNKDEIFHHMVIGSHGQWFDSANVIVAANSKPTPQRNARRWACTNCERRFARHRRMMYHRVWECPGRRKLSVGCQFCRRKFRSWSRARAHVCICPKRALRHSRLKWKMGLEKVKLRQTDTSRVDGQEEVVITKYPCSMCDRSYSNASNLRRHLSTHRPQDQWNHKCGVCFKVFDKLFDLKRHLQIASCGNGGNTIAVQASETQGQEVELPSVPLHTVPEAPPPADVLEGTLNTTPPSTSVDRLLYVCSTCNKMFQSYNSLKMHEPIHTGAKTYICETCGKRFSGPSNLWQHRLTHSEVRQFNCNQCPKVFKRKGGLSQHIRAIHMNIKPYQCATCGHEYALKADMTRCRHSRLHESAIPAC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00106552;
90% Identity
-
80% Identity
-