Adir000031.1


Basic Information
Transcription Factor Domain
Sequence Information
Similar Transcription Factors

Basic Information

Insect
Anopheles dirus
Gene Symbol
Ankfy1_1
Assembly
GCA_000349145.1
Location
KB672891.1:760688-774156[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.8e-15 1.1e-12 47.6 0.0 8 108 84 178 79 180 0.91

Sequence Information

Coding Sequence
ATGGCGTGTTatcaagaacaaaacaaatcatcaggCAGCGCTGCAAGCGCGACCACCAGTGAAACAGTCAAACTGGAGAAACACCTTAAACTGCTGAAGGAGGAGTACACCAAGCTGCAGAAAAGTTATGCCGAGTTGGAGCGTAAATATAGCCAGGCGGCTGCCGCAAACGAAGAGCATGACTTGTCCGGCGAGTTTAGCAGCTTCATTTCACGCCTGGTCATGACCGTGGCTACACTCTACGGGCGAACGACATACTCGGATATTACGATCAAGCTGAAAGACAAATCGATGCCGGCTCACAAGTTTGTGCTGAATGCCCGCAGCGAAGAGTGGCGAGAGGAGGTTTTGATGGACGAATGTGAACTAGATTGGTCCGACATGGACGCCGATGTGGGGTACGCATTGCTGCGCTGGATTTACACGGATGTCGTTGACCTCCAGCACGATTCACTGGCGCTGGAGCTGTTGAAAACGTCCCATAGGTTTAAGCTTCCCGGCCTAATGGGGCTCTGTGAACGTGCTCTTGTGTCGTCGGTATCGGTCCGGTCCTGTGTACGGTTTTACTGCGTTGCGGAGGAGGTGGGAGCCGCAAACTTACTCGAATACTGTTCCGGGCTCATCTCCACGCACTGGGATGACCTAACGCCACAGGACTTCGAGCACATGTCAGGCGCACTGCTGTATAAAATGcttaaaagcaaaaccaaacatcCGCTCCATGCTGCCGTCCGGTTACTGCGCGAGGACGTCGTGTTCCTGTGCTTGGTGGAAAACAATAGTTCGCTACAGGAAATCGTTAATAGCCTTTCACCCCAAGGACAACTACCGTTGGGTTTAGCGCTAATGGGACGCAGCACAGCCATCGCACAGACACTGCTCGAAACCGGTGGTGCCGACATGAATGCCTACACAACTGAGGGAAACACGCTGCTAATCGATGCTATTAAGCGCGGCGACAGCTTTACAGCACAATTTCTGCTGGAAAAAGGATGCAACGTCGATCTGGTCACAAGAGACACGTCGGATACGGCGCTGCATCTGGTGTGCACGTACTCGGAGCGAAGCACCGATGCGGAAACTCATCGCGAGATGCTCAGCATCGGGCGACAGTTGCTGAAGCAACAGGCCGACCCGAACATGCAGAACAGCAAGGGCTACACTCCACTGCACGTGGCTATTATGTCCCAACACGTGGAAATGATCGACGAGTTGTTGACCGAAACCGACGGTTCGTACGTGGACACAAACATACGAACGAAGGATGAGAAATGTGCCTTACAGCTGGCACTGATGCCACCGCATACGGATGGTGCTCCGTTTGAGTTGGCCCGCCGGCTGTTGGAACGCGGGGCCCGTTCTAACGTCATCAATCCGGAGACGGGTGACAGTTTACTGCACAGTTTGGCCAAACAACAGCTGGAGGACGCTGCCGTCTTTCTCACCGATCATTGCAACCTGAGTCATATCAATCGTTCCGGATTGACTGTTCTGCACGTGGCTGCCTCGCAAGGGCTGGCGAACCTTACTCGGGCTCTGTTGGAGAAGGGCGCACCACCTAACGTGCAGTCCGGTGTCACGGAACTGAAAACGGCATTGCACTACGCTGTGGAGGAGAATTACGCCCCTGTGGTGGAAGCTGTAATCGACTATAAGGAAGCCAACCCACCTGGCACGGTAGATTTCAACGTGAAAAACGCCTTCGGCGACTCGCCGCTAAGTTTGGCTCTAAGTCTAGGTTACAACGAGCTTGTGCCGCTGCTCATCAAGGGCGGGGCGGATGTGAACGCACGCAACGGTCAGGATATGACGCTTCTCCATCAGGCGATACTGAAGGAGGATTCCAAAACGGCCGTATTTTTGCTCAGTCAAGGTGCAGATATGAATGCGCTGACGGCGGACCAGGAGTCACCTCTGCAGCTGGCCATCCACTGCCGCTTGGTCGACGTGGTAGATGCGCTTTGCTCTCGTGGCGTATCGCTGAGCGCACCGGACAATAAGGGTGACTGTCCGCTGTGGAGTGCGCTGGAGTCGGAGCAGTTCGAGATTGCTTCGGTGCTTGTGCGACACGGTGTGGACACGGACTGCTGGGGCCCGGGACCGGAAGGATGCTTGCAGACTCTGCTGCATCGTGCGATCGACGAAAACAAGGAGCAAGCAGCCATGTTCCTTATCAAGAGTGGTTGCGACTTGGACTCACCACGGCAACCGGGCCCACAGGGTCAGGGTGGTGACGAGGCGAAAGACAAAGCATCCCCATTGCATCTCTGCTGCCAGTGGGGTCTACGGAACGTGTTGCACACGCTGATTGGGCATGGTGCGAACGTAAATGCCGTCGATTGCGATCTGAAAACGCCACTACACGTAGCGATTGAGAATCAGCACGAAGAGATTATTGGCATTCTGCTGTGCCATCCGGGCATCGATCTGAAGATACGAGACAAAACGGGCAACACACCGTTTGCGGCAGCTTTGCAAGTGCGGAACAATAAGGCTGCGCAGAACATTCTCGAACGGCTTCCCAATGCAGCGGAACAGATCGATCAGCGGGGACGAAATTTTCTGCACCTGGCAATCATGCGGGATGATCTTGAGTCGGTCCTATTCCTCCTTTCGATCCAGGTTGACGTGAACTCCCGGGTGCACGACGTCAACCAGACACCGCCGCTGCATCTAGCCGCAGCCTCGGACAAGGAGATGCTTATTCGGAACCTCATTCTGGCCGGTGCTCGTTTGAACGATCGCGATGCCACACAGAAAACGGCTCTGCATGTGGCCGCCGAGCGGGGTACGGTGGGTGCGGTGTCAGCCCTGCTACAGAACGGTGCGGATTTCGATGCAGTTGATGGCGATGGCAATAATGCGCTTCACATCGCGGTCCGCGAGGGTCACATTGCGGTCGTACGAGAGCTGCTGACGGAGTCGGAACTGAACGCGGAGGCGGCTAATCTGAAGGGCCGCAATCCGTTACACGAATTGTGCCGCTGCGGCAAGGATAATACGGCCGCCGCCATACTGGAACTGTTTTTCGAGTGTATGCCAAAGTATCCGATCAATAACCCCGATCTGCAGGGCAATACGCCCCTTCTGTTGGCGTACATGCGCGGCCAGGCACAACTGTGCCGCATTCTGGTGAAGAACGGCGCTTGCCTGGGTGCGGAGAATAAGGAGGGCTTGACGATATTCAACTTTAAGTTAGCCACCAATCAACTGTTGCATCGTTTGCTGGACGAACTGCCACAGGAATCACCGTGGGCGTCGTCCGAACTATGCCAGGAGTGTGGCACCAAGTTCACTCTCACGATGCGGAAACACCACTGCCGTCACTGTGGGCGAAACCTTTGCAGCCGATGTTCGAACAACGATGTGCCAATTATCAAATTTGGCATCAATAAACCGGTCCGAGTGTGTTCGGTTTGCTTCGAGGTACTACAAATTGGGAGCGGTGTTGTTTAA
Protein Sequence
MACYQEQNKSSGSAASATTSETVKLEKHLKLLKEEYTKLQKSYAELERKYSQAAAANEEHDLSGEFSSFISRLVMTVATLYGRTTYSDITIKLKDKSMPAHKFVLNARSEEWREEVLMDECELDWSDMDADVGYALLRWIYTDVVDLQHDSLALELLKTSHRFKLPGLMGLCERALVSSVSVRSCVRFYCVAEEVGAANLLEYCSGLISTHWDDLTPQDFEHMSGALLYKMLKSKTKHPLHAAVRLLREDVVFLCLVENNSSLQEIVNSLSPQGQLPLGLALMGRSTAIAQTLLETGGADMNAYTTEGNTLLIDAIKRGDSFTAQFLLEKGCNVDLVTRDTSDTALHLVCTYSERSTDAETHREMLSIGRQLLKQQADPNMQNSKGYTPLHVAIMSQHVEMIDELLTETDGSYVDTNIRTKDEKCALQLALMPPHTDGAPFELARRLLERGARSNVINPETGDSLLHSLAKQQLEDAAVFLTDHCNLSHINRSGLTVLHVAASQGLANLTRALLEKGAPPNVQSGVTELKTALHYAVEENYAPVVEAVIDYKEANPPGTVDFNVKNAFGDSPLSLALSLGYNELVPLLIKGGADVNARNGQDMTLLHQAILKEDSKTAVFLLSQGADMNALTADQESPLQLAIHCRLVDVVDALCSRGVSLSAPDNKGDCPLWSALESEQFEIASVLVRHGVDTDCWGPGPEGCLQTLLHRAIDENKEQAAMFLIKSGCDLDSPRQPGPQGQGGDEAKDKASPLHLCCQWGLRNVLHTLIGHGANVNAVDCDLKTPLHVAIENQHEEIIGILLCHPGIDLKIRDKTGNTPFAAALQVRNNKAAQNILERLPNAAEQIDQRGRNFLHLAIMRDDLESVLFLLSIQVDVNSRVHDVNQTPPLHLAAASDKEMLIRNLILAGARLNDRDATQKTALHVAAERGTVGAVSALLQNGADFDAVDGDGNNALHIAVREGHIAVVRELLTESELNAEAANLKGRNPLHELCRCGKDNTAAAILELFFECMPKYPINNPDLQGNTPLLLAYMRGQAQLCRILVKNGACLGAENKEGLTIFNFKLATNQLLHRLLDELPQESPWASSELCQECGTKFTLTMRKHHCRHCGRNLCSRCSNNDVPIIKFGINKPVRVCSVCFEVLQIGSGVV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00100424; iTF_00097898; iTF_00099779; iTF_00098501; iTF_00092276; iTF_00092925; iTF_00400773; iTF_00401887; iTF_00093578; iTF_00097200; iTF_00102483; iTF_00107799;
90% Identity
iTF_00097200;
80% Identity
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