Basic Information

Insect: Anopheles cruzii
Gene Symbol: -
Assembly: GCA_943734635.1
Location: OX030880.1:80424532-80427532[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 16 0.93 56 4.3 0.7 2 23 222 244 222 244 0.95

2 16 0.0021 0.13 12.6 0.1 2 21 254 273 253 274 0.94

3 16 0.94 57 4.3 1.2 1 21 281 301 281 302 0.93

4 16 0.047 2.9 8.3 3.7 2 23 419 441 419 441 0.96

5 16 0.034 2.1 8.8 2.6 1 20 482 501 482 503 0.94

6 16 0.0069 0.42 11.0 1.1 2 23 581 603 581 603 0.95

7 16 0.1 6 7.3 0.1 1 20 618 637 618 638 0.95

8 16 0.011 0.66 10.4 2.2 1 21 652 672 652 673 0.96

9 16 2.6 1.6e+02 2.9 5.3 2 23 734 757 732 757 0.84

10 16 0.4 24 5.4 0.5 2 20 774 792 773 793 0.93

11 16 3.5e-05 0.0021 18.2 0.3 1 23 801 824 801 824 0.97

12 16 7.8e-05 0.0048 17.1 0.6 1 23 831 853 831 853 0.97

13 16 0.0014 0.084 13.2 0.3 1 23 859 882 859 882 0.95

14 16 8.1e-06 0.00049 20.2 0.3 1 23 888 910 888 910 0.98

15 16 1 61 4.2 5.4 3 23 918 939 916 939 0.95

16 16 6.2e-05 0.0038 17.4 0.5 1 23 945 967 945 967 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	16	0.93	56	4.3	0.7	2	23	222	244	222	244	0.95
2	16	0.0021	0.13	12.6	0.1	2	21	254	273	253	274	0.94
3	16	0.94	57	4.3	1.2	1	21	281	301	281	302	0.93
4	16	0.047	2.9	8.3	3.7	2	23	419	441	419	441	0.96
5	16	0.034	2.1	8.8	2.6	1	20	482	501	482	503	0.94
6	16	0.0069	0.42	11.0	1.1	2	23	581	603	581	603	0.95
7	16	0.1	6	7.3	0.1	1	20	618	637	618	638	0.95
8	16	0.011	0.66	10.4	2.2	1	21	652	672	652	673	0.96
9	16	2.6	1.6e+02	2.9	5.3	2	23	734	757	732	757	0.84
10	16	0.4	24	5.4	0.5	2	20	774	792	773	793	0.93
11	16	3.5e-05	0.0021	18.2	0.3	1	23	801	824	801	824	0.97
12	16	7.8e-05	0.0048	17.1	0.6	1	23	831	853	831	853	0.97
13	16	0.0014	0.084	13.2	0.3	1	23	859	882	859	882	0.95
14	16	8.1e-06	0.00049	20.2	0.3	1	23	888	910	888	910	0.98
15	16	1	61	4.2	5.4	3	23	918	939	916	939	0.95
16	16	6.2e-05	0.0038	17.4	0.5	1	23	945	967	945	967	0.98

Sequence Information

Coding Sequence: ATGAGAAGAACTTCGAAACGAAGGAAGGTCGCAGTGAAGCGAGATGAACCTACAGCATCCACACGAATATGCAGCATCTGCACGAAGGAGGCGTCCGAAGAGACGACGCTTTCACTATCCGTGGTTGTTGACGACGGACATCGTAACACTGTGGGTAGCATTATGGAAGAGCTAGCGTCGATCAAGATCAATCAAACCGAACGGTGCATCTGCGCACCGTGTTGGAAGCGGGTGCTGGAAGCACAGGAACTGCGGAGCGCAATACGCAGTTCGAAACTCCTCGGTGACGCCAGTGAGGAATCCGCCATCGAGTGCCCGGTGGTGATCCAGCCATGCCCGCAGGAGGACAGCAAAGTGTACGAGGAGTACGAGTATTTGATGGAATACTTCGAAAACTGCGGATCGAACGATCACACCTACAACAATCGAGAGGACGAGGACGAAGTCTCCACGGTGGGGGACGAATACTATGTTAAAGATGAAGACCAAGCAGATGAACGGTCGTCGTTCCTGTTTGAGACAAACATTATTGCCGATAGCAAACCGGACGGCGATGAAAATCGGTCCGCGAATATTACGCGCCAGTTCGAGATGCCGGACTCGTCGCTTATCGTGCACGACGAACTGCACGAGCGGCACCGGCGGGTGGAGGTGGCCGGGGAGCGATGCTGTGGCTGCAGCTACGTTGCGCCCAACCGCAAAGGCCTGATGCAGCACTCGGAAACGGTGCACGCGATCAATATAGTCGACATTGGCGATTACTGTCCGATCTGTTTCTACAAGTTCGCCACCGACCAGCAGCTGGAGCGGCACATACAGGAGTTCAAGTCGAACAGCATGTACGTGTGTTTGCGGTGCAACCGATTCTACAACATGCGCCGCCGTCTGTACAATCACCTGCTAAGGTGCTGGGACGAAGAGCTCGGTGGTGCGCTGAATGGCGAGGACTCGCCAGATGAGAACGAGGATGACGACGGGCAGGACATGGACGAACTCGACGATGAGGCTGAGGTGTATGGCGAAGAGGTCCCAGGCGAGTACGACACGATCGAGTACCTTCTGCAGCAGGACGACGCACCGCTCCGTGGAATCGATCGCCGGCGGATGCACCGCTACCGGGATCAATTTCCCGAAGTTCTCGCTAACGTCGAGCTATCGTACGGGCTCGGTGAGGACCAGCTGAACATAAATCCGAATCAAATCATCGCGCAGGGTGAGTTCGAGACGTTCAAATATGTGCGATTGCGCGGGGAACGTTGCTGCGGCTGCCCCTACACGTGTTCCACGCGCGAGAAGCTGATGGAACACGCCAACCGTGAGCATCCGGAAGGGCCGTTGACGGATGCGGTCGACGATCGGACCACGTGTGGACTGTGCCGTGTGCAGTTAGGGGACGAAGTGGAACTGGTGAAACATTTAAGCTTCTTCGTGAGCAGACAGCTCTTTTTCTGCACCATCTGCCGCGAGTCGTTCCTGACGCGCGACAGTCTGCGGCACCATCAGGAGCACAGTAAGGTCCACCAGCACGAGGTGCTCGAGCGTCACCAGGAGGCCGGTCTGAAGGCGGAGGACTTTGTTGAACTCGATCGGCCGGATGTGGGGGAGCGGCTAGAGAAGCTGCTGGCGCTCAGGATGGTCAATCGCATGAAGGGGTCCCGCCACATGCGCATGCCGGACGCTCGGTTCATCAAGGAGGTGGTAGAGTACAAAAACTACCGCAAGCTGACCGTCGTCGGCGAACAGTGCTGCGGGTGCGGAATGTTTTTCGACACCACGGCCAGCCTGAAGGAGCACTCCCGGGAGGCGCACTTTACTCCGATGGCGCACGCGGACAGCCCCTGGAAGGCGAACCACGAGTGCGAGATTTGCCACACGCAGTTCGAAGGCGAGCGTGGCCTCGCGCTGCACATGGGTGCGTCCCGGGTGAACCGGGGCAAAAGCACGACCAACCTGTACGTCTGCAAGCTGTGCGGGTTGCTGTTTTCGAAAAAGTTTTGCCTCGGAAGACACATGCAGTTTGCGGCCAATCACCTGTCGCGCCTGATCGAGGATGCGACCCGGAGAAAAGCGGACGACGCTGCTCCGGAGGACGAAGACGACGATAGGAGTGCCATCAGCCAGGATCCGCGGATTGCGGAAGCGCTGCAGTTGCACAAGACGATGCGCACGGACAAGGCGGGGGCCCAGATTGGGCACCACTGTTGCTTCCCCAAGTGCCGCGTTCGCTTCACCGACGAGTCCGAGCTGCTGGAGCACGTGCACGACGAGCACGGCGGAAAGCGGCGCGAGTTTGAGTGCGAACGGAAGTCGGAACAAAACGTGTGCCCGGCTTGCTGCAAATCGTTCGACACTCGGGCCAAACTGAACTGGCACCGCGTGCAGCGCTTCGTGCCGCGCCGATACAGCTGCAAGCGCTGCGACAAAACGTTCGAAAAGTGGCCACTGCTGAAAATTCACGTCGCCACCGATCACGAGAACGCGCCGCCCAGCTTCCCGTGCACGCAGtgcaacaaaacgttcatcaacgtgtcgcgcctgcgggttcacgagaaaattcacgacacgcacctccggttcgcgtgcgacgtgtgcggtgaccggttccggtacaacggcttgctttcgcgccacaaacgggcgatgcactcgagcgagctgcgcttcgagtgtaagctgtgcccgaaaaagtttgccgttgcggaaaagctcaagatccaccagcgagtgcacacgggggaccggccgtacggttgcacgttctgcagtcgccactttagccactttaccgaccggaagcgccacgaaatgtcggcccacacgggcgaacggccgcaccggtgtccgttctgtcccgcggcgtacatccgcaaccgtgagctggccatgcacatgcggaagcacaAGGAACACGAAGAACCTACCGACGGCAAGATCGTCGAGCAATGA
Protein Sequence: MRRTSKRRKVAVKRDEPTASTRICSICTKEASEETTLSLSVVVDDGHRNTVGSIMEELASIKINQTERCICAPCWKRVLEAQELRSAIRSSKLLGDASEESAIECPVVIQPCPQEDSKVYEEYEYLMEYFENCGSNDHTYNNREDEDEVSTVGDEYYVKDEDQADERSSFLFETNIIADSKPDGDENRSANITRQFEMPDSSLIVHDELHERHRRVEVAGERCCGCSYVAPNRKGLMQHSETVHAINIVDIGDYCPICFYKFATDQQLERHIQEFKSNSMYVCLRCNRFYNMRRRLYNHLLRCWDEELGGALNGEDSPDENEDDDGQDMDELDDEAEVYGEEVPGEYDTIEYLLQQDDAPLRGIDRRRMHRYRDQFPEVLANVELSYGLGEDQLNINPNQIIAQGEFETFKYVRLRGERCCGCPYTCSTREKLMEHANREHPEGPLTDAVDDRTTCGLCRVQLGDEVELVKHLSFFVSRQLFFCTICRESFLTRDSLRHHQEHSKVHQHEVLERHQEAGLKAEDFVELDRPDVGERLEKLLALRMVNRMKGSRHMRMPDARFIKEVVEYKNYRKLTVVGEQCCGCGMFFDTTASLKEHSREAHFTPMAHADSPWKANHECEICHTQFEGERGLALHMGASRVNRGKSTTNLYVCKLCGLLFSKKFCLGRHMQFAANHLSRLIEDATRRKADDAAPEDEDDDRSAISQDPRIAEALQLHKTMRTDKAGAQIGHHCCFPKCRVRFTDESELLEHVHDEHGGKRREFECERKSEQNVCPACCKSFDTRAKLNWHRVQRFVPRRYSCKRCDKTFEKWPLLKIHVATDHENAPPSFPCTQCNKTFINVSRLRVHEKIHDTHLRFACDVCGDRFRYNGLLSRHKRAMHSSELRFECKLCPKKFAVAEKLKIHQRVHTGDRPYGCTFCSRHFSHFTDRKRHEMSAHTGERPHRCPFCPAAYIRNRELAMHMRKHKEHEEPTDGKIVEQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00094677;
90% Identity: -
80% Identity: -