Basic Information

Insect: Anopheles cruzii
Gene Symbol: Hr39
Assembly: GCA_943734635.1
Location: OX030880.1:68059615-68062824[-]

Transcription Factor Domain

TF Family: SF-like
Domain: zf-C4|SF-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.0064 33 3.5 3.2 76 188 88 220 46 233 0.60

2 4 3 1.6e+04 -8.0 7.8 78 115 339 382 308 481 0.60

3 4 5.3e-08 0.00027 20.2 0.0 1 21 574 594 574 603 0.93

4 4 8.1e-78 4.2e-74 250.2 0.0 176 408 696 924 668 924 0.92

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.0064	33	3.5	3.2	76	188	88	220	46	233	0.60
2	4	3	1.6e+04	-8.0	7.8	78	115	339	382	308	481	0.60
3	4	5.3e-08	0.00027	20.2	0.0	1	21	574	594	574	603	0.93
4	4	8.1e-78	4.2e-74	250.2	0.0	176	408	696	924	668	924	0.92

Sequence Information

Coding Sequence: ATGAAAATAATGACGTCAACGGAAATCACCGGATCGCCGACGAGTCGCGGCGGTAACGTGTCCGTCACGGCGATCAACTGCAGCGACGATGGCGGAGGAGGACCGGGTGGAACCGGGGGCGGAACACCGGTGTCGCTGGACGCCAAGTTGGCCGCTGCTTCCTCTGCATCGGGCACCGCCACGCTCCTCAGCCACAACAACAACAACAACAACCATATCGCAAGCAACAACAACAGTGTGGTTGCGTGTAGCAACAACAACAACACCGTCGGTGGCCAGGGAACAGGGATTTTTGGGGCCGTCGGGAGCGCCAGCATCCGGATCACTGTGCCGAAGATGGAGGAATCGGATGAGTCCGATACGGAGCTGTCGAACATTGAGAAGTCGGTGACCACAAACGGAGCGGCCGCCGGAGGAGTGGTGGTCAGCATGCGGGAACACGAGCGTAGCGCCAGCAAAAGCCTTCCGCGCCCAATGTCCTGGGAGGGTGAGCTCTCGGAGCCGGAAGCGATGATGGTGGACAACGAGAGCAGCAGTAGTAGTAGTAGTGGCGGCAGTAGCAGCAGCAGTAGCAACGACAAGATTGCCGTAGGCTTGATGACCCCGATCGAACCGGTCGTCGCGTTGAAGCAGGAACGATCGGAAGACGAACAGCAACACCAGCAGCAGCAGCAGGAGTCGCAAGGAGTGCAAACTCCCGGACCGGGCATTACGGAACCGCTGGCACTTACGGCCAGCGCTCCTCAACATGGGACTGTGGTGGCGGCGCCGTCCCCGGCCGGCTTGCGGTCCAGTGTGGCCAGTAACTCACCGCTCCCCGGTCGACTGTTGATCAAACCCGAAGCAGGACTCCCATTAATCACGCCCGGTTTGGCGTACAACGCGTCCAACATTCCACCCACCAGCGGCCTACCGTCGGCCAAGAAACTCCCGGATGTGATCAACCTCAAGTACGAGCTGCCACCGACGACACCGGGCAGTTCGGAGCAAGCAGGGTCCACAACGATTCACTCGCCGCTGCTCGTTCGCTCCAAAACTACGCTCCTTCCGGCCAACCCGAGTCCCGATTCGGCCATCCACTCGGTGTACACGCACAGCTCACCGAGCCAGTCACCGCTCACGTCCCGCCACGCACCCTACACGCCGTCGCTGAGCCGAAACAATAGTGACGCATCGCACAGCAGCTGCTACTCGTACTCGTCCGAGTTCAGCCCAACCCATTCGCCGATCCAGGGACGTCACAGTATATTCGGTGGTGGCACCGGTGCCGGGGGCGGTGTTAATGGCACGGCGAGCGCATCCTTTAACGGGTCGCCCCTGCACCACTCAGTATTATTCAAACCGATGCTGGACGGGGCCGATCCGCAGCAGCAGCAGCACCATCAGCAGCAGGCTGCCCTCAAGCAGCTGGCTGCGGCGGCGGCCGCTGCCGCCCAACAGGACGATTCGCTGTACGACGGAGAGCATCTGCCATCGCCCGGTATCTCCCGGCAGCAGCTAATCAACAGTCCCTGCCCGATTTGTGGTGATAAAATTTCCGGCTTCCACTACGGCATCTTCTCGTGCGAGTCGTGCAAGGGGTTCTTCAAGCGGACGGTGCAGAACCGCAAGAACTACGTGTGCCTTAGGGGGGCGGCCTGTCCTGTGACGATAGCGACGCGGAAAAAGTGTCCCGCCTGCCGGTTCGAGAAGTGCCTTCAGAAGGGAATGAAGCTGGAAGCCATCCGAGAAGATCGAACACGTGGTGGCCGATCGACGTACCAGTGTTCGTACACCCTGCCAGGGCCGCTGGTGAGCGCCGTTGGAGGGATGCAGCCAGGCAGTGACTCCCCGGTGACCGGTCCGTTTCAGTATGGCGGCAACGCGGTACGATCACCGTACGTTGGTGGTGGCCCAGGCTCCGGTGGTCAGCAGCTGAAAATGGAACCGGGTGACGGTGGGGCGCCGATGATGGGTGGGCTGAACGGGACGATGATCGGTGACGGCGGTGGTTCCGGCATCGGTAATCACCTACAACCAGGCATTCCAGTGTTGCTACAGGAAATCATGGACGTTGAGCCACTGTGGCAGTACAACGCGGCCGAGCTGGCCCGGCTCAATCAGCCGCCACCGGCGGTGAGCAGTGCGGCGATCGCCAGCAATCCGCTACTCTCCAGTGCCGGCATCTCGTCCGAAAGCAGCCCGGATCTGATCGCCAACCTGTGCAACATCGCCGACCACCGGCTGTACAAGATCGTCAAGTGGTGCAAGAGTTTGCCGCTGTTCAAGAACATTTCGATCGATGACCAGATCTGCCTGCTGATCAACTCGTGGTGCGAGTTGTTACTATTTTCCTGCTGCTACCGTTCGATCGCGACTCCGGGCGAGATCAAGATCTCGCTCGGGAAGTCGATCACGCTCGAACAGGTGAAAAACAGTGGATTGCAGACCTGCATCGAACGGATGCTTCACCTGACGGACCATCTGCGGCGGCTGCGCGTCGATCGGTACGAGTACGTCGCCATGAAGGTGATCGTTCTGCTGTCGTCCGACACCTCCGAGCTGAAGGAGTCGGAAAAGGTGCGTGCAAGCCAGGAGAAGGCCCTGCAAGCGCTGCAGGCGTACACGCTTGCCTACTACCCGAAAAGTCCGGCCAAGTTTGGCGAGCTGCTGCTCCGGATTCCGGAACTTCAGCGAACCTGTCAGGTTGGCAAGGAGATGCTGACGATCAAATCGAAGGACGGCGAAGAACCATCATTCAACCTTCTCATGGAGCTGCTCCGCGGCGAACATTGA
Protein Sequence: MKIMTSTEITGSPTSRGGNVSVTAINCSDDGGGGPGGTGGGTPVSLDAKLAAASSASGTATLLSHNNNNNNHIASNNNSVVACSNNNNTVGGQGTGIFGAVGSASIRITVPKMEESDESDTELSNIEKSVTTNGAAAGGVVVSMREHERSASKSLPRPMSWEGELSEPEAMMVDNESSSSSSSGGSSSSSSNDKIAVGLMTPIEPVVALKQERSEDEQQHQQQQQESQGVQTPGPGITEPLALTASAPQHGTVVAAPSPAGLRSSVASNSPLPGRLLIKPEAGLPLITPGLAYNASNIPPTSGLPSAKKLPDVINLKYELPPTTPGSSEQAGSTTIHSPLLVRSKTTLLPANPSPDSAIHSVYTHSSPSQSPLTSRHAPYTPSLSRNNSDASHSSCYSYSSEFSPTHSPIQGRHSIFGGGTGAGGGVNGTASASFNGSPLHHSVLFKPMLDGADPQQQQHHQQQAALKQLAAAAAAAAQQDDSLYDGEHLPSPGISRQQLINSPCPICGDKISGFHYGIFSCESCKGFFKRTVQNRKNYVCLRGAACPVTIATRKKCPACRFEKCLQKGMKLEAIREDRTRGGRSTYQCSYTLPGPLVSAVGGMQPGSDSPVTGPFQYGGNAVRSPYVGGGPGSGGQQLKMEPGDGGAPMMGGLNGTMIGDGGGSGIGNHLQPGIPVLLQEIMDVEPLWQYNAAELARLNQPPPAVSSAAIASNPLLSSAGISSESSPDLIANLCNIADHRLYKIVKWCKSLPLFKNISIDDQICLLINSWCELLLFSCCYRSIATPGEIKISLGKSITLEQVKNSGLQTCIERMLHLTDHLRRLRVDRYEYVAMKVIVLLSSDTSELKESEKVRASQEKALQALQAYTLAYYPKSPAKFGELLLRIPELQRTCQVGKEMLTIKSKDGEEPSFNLLMELLRGEH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00094505;
90% Identity: iTF_00097096;
80% Identity: iTF_00097096;