Basic Information

Insect: Anopheles cruzii
Gene Symbol: egg
Assembly: GCA_943734635.1
Location: OX030880.1:75339825-75344487[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 5e-17 1.3e-13 50.1 0.0 10 75 807 866 803 868 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	5e-17	1.3e-13	50.1	0.0	10	75	807	866	803	868	0.93

Sequence Information

Coding Sequence: ATGGATTCCGAAACCGGCGCGGACAGTGCAGTTCGTGATAAGGAGTTGGATGTGAGCACCATTCTATTAGAATCCGATGAGGAGACAGAAACTAGCAAAACCGAAGAAAATGTCCCTTCAATGTTGGAAAATACTACCAAATCGAACACAATGGAACCAAAATGCCCTACACCTACAGACGAGTCACCTAAGACGAATGCTCAGACGAAGCAAGACGAACAATGTGAACTTTCGGAAGCTTCTTTAACGACCATGGAACGGAGAGATGATGTAATTCTGATAGACGATGACGACAAGGACGCTTCCCAAACATCCAAGTCCAACCCACCATCTGAATCCGTTGCGTCTCCAAGGGCAACTCCACCAGCGCAAGATGAAACTGTTCGAAAAAACGTTCCCGATAACCCCAACGCTGAAAAGACATCGGAAAACGAAGCCGCACAGCTCGCAGATGGCCATGACAGGGCACAACCGGCAGACAAACCTTGTGTCCAAACGGAGGAACTTGACTTGATCGGCGAAAGTACAAATGAAAATGGCAAAGACGATGAACAAAGTAGCATTGTAGCAAACGACACAGACAAACCGGAAGATGTAGATAAAGAAGTTGACATACCGGCACCGGAGGAAGATACCGTTAAAGAAGCCCATGACATCGCCAATGTGGAAAAAGTAGCTGAACCAGATGTGGAGAAGTCCACAAATGATTCAAACGGCACGGTCAAAGAAAAAGAGATCACCGAAACTGCAACTTTCGAATGCTGCAATACGGAGTGTCCCAAACTTTGCACTGAATTTATTCCAGCAACTATGTTTGCAATGAAGTTCTACGATACTTCGAAGAAAAAACGTAAACCGTACGTGTGCAACGATTGCTTTGAAAGTTGCGTGCATCACTATGAGACTTTGTGCTCCATGATGCTCGATCACCAGCCGTTGGCGAAGTCCATTAGGAAGGCGAAGGAGTTTGTGGAAATATCTGACAGCAGCGATGAAGAGGACGAAAAAGAAATCTTTCAAGGCAATGAAGCACCGGTGCCTGAAAACATAATTTCGTTTATGGAATCGGAATTGATGAATGTGCTGGGCGCAACACTCAAGAATACTCGGGCCGACAAACAGGTGAACTGGACCATGTCAGCGATGAAGAAGAACATTGAAAAGAACAAAATTGCGACCGAAAAGATGGAGACCGAGCTGAGAGACCTGCAAAGAAGTGTAGACACGATATTTAGGGATCTTTACTCGTCGAAACAAAGATACGAGACCAGGTTACTGCCCGATCTTCACATAATCAACGGTGAAGAACAAATGATTATGCTTCGTCGCCCGGCCCCCGAATCCAAGCAAACCTACTACGGGCTCACTGAAAAGCTGCCAGGAATATGGCAAAAATGTTCAGTCGTCAAAAAGGTCCTGGAATCACACGGCTATGCCTTCTGGGTACAGTTTCCTCCCGAGTCCGTGCGTCCTTCCAACACAACGTTCAATCTGAAGCTACATTCGGCCACACATCTCGCCTACCTCGATGCGCCCGATGTGAAGCTTCAGACCGGTACACGCGTGATCGCTAAAATCCGATCACGGGACAAATCGGATGGCACGGACTCTAGACACCGGGGCAAAGATTCCTTCTACGCCGGCATAGTGGCCGAACCTGTTGGGCTCGCCAATAACTACCGGTATCTGGTTTTCTACGATGACGGGTACGCACAGTACATAAACCAAGAAGACGTCCGGGTTGTGTGTGAGCAGTCGGAGAATGTTTGGGACGATGTCGCTGAACTTTCGCGGAATTTCATCAAAACCTATCTGGAAAACTATACCGCTATGCGGGTAATGGTGCAGGTTAAGCCAGGCCAACGTTTGCGAACGGAGTTGAACGGGAAGTGGCACGCAACTACGGTTGTGGAAATCGATTGCAGCTTGATTAAGCTACAGTTTCAAGGCATGAACCACACGGAATGGATTTACCGTGGATCGAGGCGGCTCGAAAAAATGTACTTCACAGAAAACCCGCGGCAGCAACGGAACGCAAAGTTTTCCAAGCTTCAGAAACGAAACGAGCCATCGATAGAGTACATTATTACGATCGACGATGATAAGGAGGAAGAAAAGGTTGTTCAGAAGGAAAAGGTCAAAAAGGAACTTATGTCCAAAAACGAGGTATTGGCGGGGCGAGAGGAAGACGGAGCAAAGCAGACAACAAGTACAAACGTTGCCGACGCGACGGTCACCCGCCCACGGTACATGAACCAGAACATTATCTACTGTGATAATGATAAACCCGAAGGAACGGTCTCGACCTTCCCTTCCACGCGGTTCCCAGAACCGAAACGCTACACACCACACACGTGCAATCGGTCCTGTTTGTACGAAACCACATACGACTTGCGGGTTTACAGTTTCTTGGGCCATCCCCTCCTATGCGGCTGGGAGCGCCAGCTCTGCACAATACGGAACAGAAAATCGATCGTTGTTTATCGGGCTCCGTGCGGTCGCCGTCTGCGGTCCATGGACGAGGTGCACCGCTACTTGCGCCGCACGAAGGCCAAGCTGAACGTAGACAACTTCGATTTCGATCCCGAAATACGCGTACTGGCGGAGTACCGCATGAAACAGATGGTGGTCAAAATACCGGATCTATCGAATGGTCTCGAGTATACACCGGTTTCGTGTGTGAACGCTTTCGACGACACCAAACCGCCACCGTGCGACTACTCGGTTAACCGCATTCCCACCGAGGGCGTCAACCTGAACCTGAACCCGGAGTTTATGTCTTGCTGTGATTGCGAGGACGATTGCTTCGACAAGAGCAAGTGCCAGTGCTGGCAGTTGACGATAACTGGGGCGCGGTTTTTGAATCCGAAGCAACCGATCGACTCAATCGGCTACATCTACAAACGCTTGCCAGAACCGGTACTCACCGGAATCTACGAGTGCAACTCGCGATGCAAGTGCAAAAAGAACTGCCTCAACCGGGTCGTGCAGCATCCACTGCTCAACAAGCTACAGATCTTCAGAACGAACAACCGAGGCTGGGGCATCCGCTGCCTAAACGACATACCGAAGGGCAGTTTCATTTGCCACTACTCGGGCCATCTTATCACCGAGGACACCGGCAATATGATCTGCGCCGAGGACATAGGGGGCGACGAGTACTTTGCCGACCTGGACTACATCGAAACGGTTGAGAACGCGAAGGAGGGCTACGAAAGTGACGTTTCGGAGATGGAACCCGAATCAAACGACGGGGACTACGAGGAATCAAACTCTTCGCCAGAAGACGAGCTGGAAGTTACTAATTCGAAGGAAGACTCTGATGAAGATTTCACTATCAACAGCACACCCTCCAATCGTGCGGTCACAACGCGATCTCAGCTGAGACCCCGCAAAACCACGACGACGACGACGACAGTATCTCTTGACGACACGCCGGATAGCAGCGAGCCAGAAGCAACAGGCGAGAATCGAGTGCGCGAACCAATGAACTTCATGCCACGAACCGAGATGTCCCGGGGGGATCGCCTGGGCCAAAATGGAGACGAAAAGAAACCACTTCGCAGCTATTTCGGTGCAAATGAAGCAATTTACATCATGGATGCGAAGAAATCGGGTAATCTGGGACGGTACTTCAATcattcctgttcaccgaacctcttcgtgcagaatgtattcgtcgacacgcatgacgtacggtttccgtgggtagcgtttttcgccgacaaatccataaaggccggttcggagctaacgtggaactacaactacgacataggatccgtgcccggaaaggtgctgtactgtcactgcggagAAAAAGAATGTCGTAAACGTTTACTTTAA
Protein Sequence: MDSETGADSAVRDKELDVSTILLESDEETETSKTEENVPSMLENTTKSNTMEPKCPTPTDESPKTNAQTKQDEQCELSEASLTTMERRDDVILIDDDDKDASQTSKSNPPSESVASPRATPPAQDETVRKNVPDNPNAEKTSENEAAQLADGHDRAQPADKPCVQTEELDLIGESTNENGKDDEQSSIVANDTDKPEDVDKEVDIPAPEEDTVKEAHDIANVEKVAEPDVEKSTNDSNGTVKEKEITETATFECCNTECPKLCTEFIPATMFAMKFYDTSKKKRKPYVCNDCFESCVHHYETLCSMMLDHQPLAKSIRKAKEFVEISDSSDEEDEKEIFQGNEAPVPENIISFMESELMNVLGATLKNTRADKQVNWTMSAMKKNIEKNKIATEKMETELRDLQRSVDTIFRDLYSSKQRYETRLLPDLHIINGEEQMIMLRRPAPESKQTYYGLTEKLPGIWQKCSVVKKVLESHGYAFWVQFPPESVRPSNTTFNLKLHSATHLAYLDAPDVKLQTGTRVIAKIRSRDKSDGTDSRHRGKDSFYAGIVAEPVGLANNYRYLVFYDDGYAQYINQEDVRVVCEQSENVWDDVAELSRNFIKTYLENYTAMRVMVQVKPGQRLRTELNGKWHATTVVEIDCSLIKLQFQGMNHTEWIYRGSRRLEKMYFTENPRQQRNAKFSKLQKRNEPSIEYIITIDDDKEEEKVVQKEKVKKELMSKNEVLAGREEDGAKQTTSTNVADATVTRPRYMNQNIIYCDNDKPEGTVSTFPSTRFPEPKRYTPHTCNRSCLYETTYDLRVYSFLGHPLLCGWERQLCTIRNRKSIVVYRAPCGRRLRSMDEVHRYLRRTKAKLNVDNFDFDPEIRVLAEYRMKQMVVKIPDLSNGLEYTPVSCVNAFDDTKPPPCDYSVNRIPTEGVNLNLNPEFMSCCDCEDDCFDKSKCQCWQLTITGARFLNPKQPIDSIGYIYKRLPEPVLTGIYECNSRCKCKKNCLNRVVQHPLLNKLQIFRTNNRGWGIRCLNDIPKGSFICHYSGHLITEDTGNMICAEDIGGDEYFADLDYIETVENAKEGYESDVSEMEPESNDGDYEESNSSPEDELEVTNSKEDSDEDFTINSTPSNRAVTTRSQLRPRKTTTTTTTVSLDDTPDSSEPEATGENRVREPMNFMPRTEMSRGDRLGQNGDEKKPLRSYFGANEAIYIMDAKKSGNLGRYFNHSCSPNLFVQNVFVDTHDVRFPWVAFFADKSIKAGSELTWNYNYDIGSVPGKVLYCHCGEKECRKRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00094476;
90% Identity: -
80% Identity: -