Acou003519.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles coustani
Gene Symbol
egg
Assembly
GCA_943734705.2
Location
OX030900.2:36985824-36989632[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1.4 3.9e+03 -2.4 0.0 32 72 610 656 606 661 0.65
2 2 7e-14 1.9e-10 40.3 0.0 9 73 661 720 653 723 0.91

Sequence Information

Coding Sequence
ATGTGTGATGCTCAAGTACCAGATATCGAACAGCCAGCAATGGAAAGTGGCATAGAAGGAGAAATTAAAGTCGTCGAAGCATCAAACATGCCGGCCTCGGAAAACCTGCATGAGCATTGTACGATGCAGGAATCAATCGAACCGATGGAGACAGACGATGCGCAAAACAGCGCTCATGCCAAATGTAGTAATCCAGTATGCGACAGCATGTCACGAGAAATGTTGCTGGCTCCATTGTTTGCATTGAACGTCTACGAAAttcgaaggaagaaaaagccgATGTTCATGTGCAGACCATGTTTCGACGTGGCTATTCACCAATTTGAGATCCAGGCAAGTTTACTGGCCGATGGGCGGCCGTTGTACTCAATAGACGTGCCCCGTCTCAATGAGCTGGTGGAAATTTGTGACAGCAGCGATGAAGAAACTGAATCGCAGTCGGATGGTGAACAAAATGGCACGGCATTACCGGCGGATATTGTAGCACTAGTTGAGGCAGAACTAGCGGATGTTTTACAGTCGTCATTCAAAAAATACAATTTGGAGCAGCAAATCGAATGGTCCTTGGCAATGAATAACAAGAAGCTTTGTCGCCTAGAAGAAGAGTTTCAGAAATTTTCTTCAGAAGCAGCAGCTTTACGTAAAGGTTTTGATACGATTCAAAATACAATGACCGCCTGTGTCAATATTGTTGAAACCAAGTTGCCAGAAATTAACATCGTCGATGTAGATCAATTTTCCAAGCTACACATATCGACCCATGGTCACAAACCTGGAACCACAGGTGAAGTGGAGAGGAAACCAATTCAAGTCAACAATATCTACTTCGGTCTCCAGGGCTCGCTAATGGGCAGCTGGATGGAATGTAAGGTCGTCCAGGAAGTGTTGGATGTAACGACGAACGAGAAGAAGGGATACCTGGTGCAGTTTCTAAAGGGAGAAGGAACACGGGTGGTACTCAGCGCAAAACAGCTGGCCTACAGCACCTCAACAAGTATTAAAATACCCCAGGGTAATAGGATCATCGCGAAAACTTGCCGAAGGGAGGAGGATTTAGACGTAGAGCATGATGAAACCGCCTTCTACGCGGGTTTTGTAGCGGAATCGCTCCATCAGTACAACGCACATCGGTACCTGGTCATTTTTGACAACGGCAGGACATGCTACGCCCAATCCTGGAACGTGCGGTTGGTCTGCGAACAGTCGGAGCACGTCTGGGAGGACATGGATCCGCATGTGCAGGAGTTCGTGCGCGATTACATGAACGACTACAAACTGTACCGCCCGATGGTGCAGGTGCGGAAGGACCAGCGGCTGATGACGGAACGGGGTGGAAAGTGGCGCCGGACGGTCGTGCTCGAGGTCGATTGCAGCTTGGTAAAGCTTTTGTACACCGAGTTGAACAAAGTGGAATGGATGTTCCGTGGCTCGAAACGGCTCGGACCAATGTACAAAGGGCGAAAGAGAGACTGGCAGCAAATTTCGAAGTTCCAAAAACGTAACATTCCCTCCATCGAGTATATTAccatcgatgatgatgatgaagatgaggaTGCCGGTGATGATGCCATGGAGAATGCCGCAAATAATGTCCAAAACACGGGAGCGGAAAGCGATGTTGGTAAATCACCTACCGTTGTTCCAACATCGCCCGTTGCCTCACCAGCGAAAGGTGGAGGTGTTGGAGTTGATTCACCACCGGACAGCAAAGCTGGTCTCGCACACTTGACCAGCGTCCTTACGCCAGGGGTTTCGGGAAAGAAGGACGTACCTGGAACTGGACGAATGCCTGCTAGAACACCGCATAAACCGATCATGATGAACAAGAACATTATCTATTGTGACGATCGACCGCAGGGGAAGACGTACATGTACACGACGAAAAACTACCGCGGCCCGGATAAGTACCTTCCCCACGAGTGCAATCCAAAATGTTTGTTCCCGCTAACGTTCGACCTAAAGACGTACAATCTGCTCGCGCGGCCCCTCATCTGCGGCTGGGAACGGCAAATTTGCAAAGCACCCGGCAAGCGGTCGAAAGCGGTCGTGTACCGTGCCCCGTGTGGTCGCCGGTTGCGCTACATCTACGAGCTGCATTCCTACCTTCGCATGACGAAGTCGGACTTGAACGTGGAACACTTTGACTTCGATCCGGAGATTCGTGCACTCGCGACGTTCAAAGCACTCAATCCCATTTTCGAACTGCGCGACCTGTCGTGCGGCAAAGAGCAGATGCCGGTTTCGTGCGTGAACTGCTTCGACGACACGAAGCCCCCGCCGTGTGAATACTCCGCCCAGCGCATTCCGACGGAGGGGGTATTTTTGAACCTGGACGAAGGCTTCCTCTCCTGTTGCGACTGCGAGGACGACTGCTTCGACAAGAATCGCTGCCAGTGCTGGCAGCTGACGGTCCAGGGCGCCCTGGCCAACAACGTGACCACGGACGTGGAAAACATCGGTTACGTCTACAAGCGCCTGGATGATGTGCTGCGGAGCGGCATCTTCGAGTGCAATTCGCGCTGCAGGTGCAAGGTGAACGAGTGTCTGAACCGGGTCGTGCAGCATCCACTGCAGACGAAGCTGCAGGTGTTCAAGACGAGCGACCGGGGCTGGGGCATTCGCAGCCTGAACGACATCCCGAACGGGAGCTTCGTCTGCATCTACGCCGGCTTGCTGCTGACGGAGGAGGCCAGCAACTTGATTTGCAAACAGGACCCAACGGGCGATGAGTACTTTGCCGAGCTGGACTACATCGAAACGGTCGAGCACGAAAAGGAGGGCTACGAGAGTGACGCGCTCGAAACGTCCGATTCCGATTCGGAGACCGAATCCGAACCGGAGACGTTCTTCAACACCAAAACCAAGAGCAGACCATCGCCCAGGGCCGTCAACACGCGTTCCACgtcgaaaaagaataaatcggGCCACGTTAAGGACAACAAAAAGTCAGGAGCAGGTCGGGAAGCTAAATCACCCGTCTCTTCTAAGCCCAAACGACTTCGTCAACTTTACGGTAAACACGAACAAATTTATGTTATGGACGCTAAAAAAACTGGGAATTTGGGACGCTACTTTAATCACTCCTGTGTGCCAAATCTGGTGGTGCAGAACGTGTTTGTCGATACGCACGATCCCCGCTTTCCTTGGGTGGCTTTCTTCGCCAAAGCCAATATTAAGGCGGGCGAGGAGCTCACTTGGAATTATGCCTACGACGTGGGTTCCGTGCCGGGTAAGGTTCTGTTTTGCAATTGCGGTGCACGGGAGTGTCGCAAACGGATACTGTAG
Protein Sequence
MCDAQVPDIEQPAMESGIEGEIKVVEASNMPASENLHEHCTMQESIEPMETDDAQNSAHAKCSNPVCDSMSREMLLAPLFALNVYEIRRKKKPMFMCRPCFDVAIHQFEIQASLLADGRPLYSIDVPRLNELVEICDSSDEETESQSDGEQNGTALPADIVALVEAELADVLQSSFKKYNLEQQIEWSLAMNNKKLCRLEEEFQKFSSEAAALRKGFDTIQNTMTACVNIVETKLPEINIVDVDQFSKLHISTHGHKPGTTGEVERKPIQVNNIYFGLQGSLMGSWMECKVVQEVLDVTTNEKKGYLVQFLKGEGTRVVLSAKQLAYSTSTSIKIPQGNRIIAKTCRREEDLDVEHDETAFYAGFVAESLHQYNAHRYLVIFDNGRTCYAQSWNVRLVCEQSEHVWEDMDPHVQEFVRDYMNDYKLYRPMVQVRKDQRLMTERGGKWRRTVVLEVDCSLVKLLYTELNKVEWMFRGSKRLGPMYKGRKRDWQQISKFQKRNIPSIEYITIDDDDEDEDAGDDAMENAANNVQNTGAESDVGKSPTVVPTSPVASPAKGGGVGVDSPPDSKAGLAHLTSVLTPGVSGKKDVPGTGRMPARTPHKPIMMNKNIIYCDDRPQGKTYMYTTKNYRGPDKYLPHECNPKCLFPLTFDLKTYNLLARPLICGWERQICKAPGKRSKAVVYRAPCGRRLRYIYELHSYLRMTKSDLNVEHFDFDPEIRALATFKALNPIFELRDLSCGKEQMPVSCVNCFDDTKPPPCEYSAQRIPTEGVFLNLDEGFLSCCDCEDDCFDKNRCQCWQLTVQGALANNVTTDVENIGYVYKRLDDVLRSGIFECNSRCRCKVNECLNRVVQHPLQTKLQVFKTSDRGWGIRSLNDIPNGSFVCIYAGLLLTEEASNLICKQDPTGDEYFAELDYIETVEHEKEGYESDALETSDSDSETESEPETFFNTKTKSRPSPRAVNTRSTSKKNKSGHVKDNKKSGAGREAKSPVSSKPKRLRQLYGKHEQIYVMDAKKTGNLGRYFNHSCVPNLVVQNVFVDTHDPRFPWVAFFAKANIKAGEELTWNYAYDVGSVPGKVLFCNCGARECRKRIL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00107687;
90% Identity
iTF_00109144;
80% Identity
iTF_00109144;