Basic Information

Insect: Anopheles arabiensis
Gene Symbol: -
Assembly: GCA_016920715.1
Location: NC:20103630-20107110[+]

Transcription Factor Domain

TF Family: HMG
Domain: HMG_box domain
PFAM: PF00505
TF Group: Other Alpha-Helix Group
Description: High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. The structure of the HMG-box domain consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. Many of these proteins are regulators of gene expression. HMG-box proteins are found in a variety of eukaryotic organisms, and can be broadly divided into two groups, based on sequence-dependent and sequence-independent DNA recognition; the former usually contain one HMG-box motif, while the latter can contain multiple HMG-box motifs. HMG-box domains can be found in single or multiple copies in the following protein classes: HMG1 and HMG2 non-histone components of chromatin; SRY (sex determining region Y protein) involved in differential gonadogenesis; the SOX family of transcription factors [1]; sequence-specific LEF1 (lymphoid enhancer binding factor 1) and TCF-1 (T-cell factor 1) involved in regulation of organogenesis and thymocyte differentiation [2]; structure-specific recognition protein SSRP involved in transcription and replication; MTF1 mitochondrial transcription factor; nucleolar transcription factors UBF 1/2 (upstream binding factor) involved in transcription by RNA polymerase I; Abf2 yeast ARS-binding factor [3]; yeast transcription factors lxr1, Rox1, Nhp6b and Spp41; mating type proteins (MAT) involved in the sexual reproduction of fungi [4]; and the YABBY plant-specific transcription factors.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 7.2e-17 4.4e-14 52.1 6.6 1 68 134 201 134 202 0.98

2 5 0.8 4.9e+02 0.7 0.0 36 54 257 275 253 281 0.86

3 5 0.26 1.6e+02 2.3 3.2 20 68 321 369 314 370 0.90

4 5 0.0044 2.7 8.0 1.2 34 68 569 603 567 604 0.93

5 5 7.2 4.4e+03 -2.3 0.1 47 62 612 627 605 629 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	7.2e-17	4.4e-14	52.1	6.6	1	68	134	201	134	202	0.98
2	5	0.8	4.9e+02	0.7	0.0	36	54	257	275	253	281	0.86
3	5	0.26	1.6e+02	2.3	3.2	20	68	321	369	314	370	0.90
4	5	0.0044	2.7	8.0	1.2	34	68	569	603	567	604	0.93
5	5	7.2	4.4e+03	-2.3	0.1	47	62	612	627	605	629	0.73

Sequence Information

Coding Sequence: ATGAGGAAACGTTCGCTTTCGGTTGCGTTCGCCCGCGCGCCCTCGATTGAGGAAATGACGAAAAAGTTCGAAGGAGTATCGTCCGAAGTGGATGAGAGCGATTCGGAGGAAGAGATCGAAGAGATCGCGGACGACGCGCCCAACGCCGGCTGGGGAGTGGCGGACTACCGGAAGCTGTTCGAGCAGCTGCGCACCGTGCTGCCCCGGAAGGACACGAAAAAGTATCAGATCACGCTGAAAAAGATCCCCTGGGAGAAGGTGGTGGTCGAGGGCCACTCCGAGGAGGATGTCAAGCAGACCACCGCACAGCTGGCAGAGAAGGCACGCAAATTTCGTACCCTGACCGAGATTATGGGCGATATGGAGCAGCTGTCGCTGGAGCTGAACTCGGTTGGCAAACCCAAACATCCGCTCACCGCGTACAATCTCTTCGTGAAGGAAAAGTTCACTGCCTTGAAAGCCAAACATCCTAACGCATCGGCCCCCGAGATGATGAAAATGCTCAGCCAGGAGTTCGCGATCCTGtcggagaaaaagaaaaagaagtacGAAGCCGTGGCCGCCGCCGCGAAGGAACAGTACAAGCAGGAGCTGGCACAATTCTACCGCGACAATCCGAATGCAGCGCCggtaaagaaaaagaaggccaAAAAAGAATCCACTCCCAGAAAAGCGAAAAAGGTTCGCCAACCCACCGCAATTACGCCGTTCGGGCTGTTCCGGGACGAGAAGCAGGGCGAGATGGACGAAATTACCGGCCTGGCGTTGCGCAAGCTCTGGGATGAGCTGGACGTGCAGCAGAAGGTCAAGTACATCCAGCGGGCATTCCAGAGCCAGTCGGACCAGACCGGCACCGTCAAGCTGAAGCTGACGAAGGAGGAGCAGTCCATGCTGCAGGTGGCGGCCGGCAAGCCGGAACCCATCCCGCGGAGCGTGTCCGACTACTACCTGAAGCGCTACACCGAGCACGATCCGTCGATGTCGTTGGCGGCCTGGCGCAAGGACAAGCTGGCCGAGTACAGGGCGCTGCCCAAGGTGCGCAAGCTGCAGCTCGAGATCGAGTACCGGCACGCGAAGCAGGAGTACGTCAGCAAGTACCAGGAGTACATCACCAACCTGGAGGACGAGACCGAGCGGCAAGCGGAAATCGAGCAGCTGCGCACGTTCATCAAGTCCAAGCTGGACAAGGAGGAAAAGCAGCAGCTCGATAACCGGCCGTTCCAGTCGCTGGTGGAATCGAACGAGGTGTACGACGTGACGCAACCGATCGCGGAATCGACGATCATTAGCGTGCCGAAGGAGATCaagaaagtgaagaaaaacaaagcgtcCAAGAAGAATGGCGGCGAGGGGGCCTCACTGGCAGCACCGCCgccggcaccggcaccggcagcagcagaccTGGGCAGcccgattccgaaaccgattaAATCGATCCTGAAAAGCCCGACCCCAAAACGGGTCCACCAGGAGGTGGTGTCGGACGAAGCCGCCGTACCGTcgccgaagaagaagaaaaaggtcTCCGTTGCGAGCAGCGAATCGGATAGCAACACggaaaagcaagcaaacaacacCAGTTCCAAGGCCAGCAGTGCAGCAGTGGACTCAAACGGACGAACCGGAAAAAGGAAAGAGCCACCACGTCCACCAAAAAACCTGCTGGAGTATTACCGACAGTTCCATTACCTCGGCAAGGATGAGAAGTGCGAGGAGTCGTTCCGGAACCTTTCCACCCACCGGAAGGAAACGTTGAAGGCGGAAATGCGCGCAGCAAAGCAGAAATACTTCAAGGACCTGCAGAAGTACCTCAAAACGGTACCGAAGGAGGGCCTCACAAAATATCTCGCGAAAATGGAAAGGGAGAAGGCCGAGGCTCGTTTGAATGCTACAAGCGACGAGGAATCGGTATCAGCCGCCACGGTGCCCAAAAAGATCCCCAAGGAGGAACCCAACGACAGCGACagcgatgaggaggaggaggaggaggagacgacgacaacgacggccACGACGGGTACGAATGGcaacaatgatgatgatgatgatgatgacgacgacgatgatgatagtAGCGATGAGTAA
Protein Sequence: MRKRSLSVAFARAPSIEEMTKKFEGVSSEVDESDSEEEIEEIADDAPNAGWGVADYRKLFEQLRTVLPRKDTKKYQITLKKIPWEKVVVEGHSEEDVKQTTAQLAEKARKFRTLTEIMGDMEQLSLELNSVGKPKHPLTAYNLFVKEKFTALKAKHPNASAPEMMKMLSQEFAILSEKKKKKYEAVAAAAKEQYKQELAQFYRDNPNAAPVKKKKAKKESTPRKAKKVRQPTAITPFGLFRDEKQGEMDEITGLALRKLWDELDVQQKVKYIQRAFQSQSDQTGTVKLKLTKEEQSMLQVAAGKPEPIPRSVSDYYLKRYTEHDPSMSLAAWRKDKLAEYRALPKVRKLQLEIEYRHAKQEYVSKYQEYITNLEDETERQAEIEQLRTFIKSKLDKEEKQQLDNRPFQSLVESNEVYDVTQPIAESTIISVPKEIKKVKKNKASKKNGGEGASLAAPPPAPAPAAADLGSPIPKPIKSILKSPTPKRVHQEVVSDEAAVPSPKKKKKVSVASSESDSNTEKQANNTSSKASSAAVDSNGRTGKRKEPPRPPKNLLEYYRQFHYLGKDEKCEESFRNLSTHRKETLKAEMRAAKQKYFKDLQKYLKTVPKEGLTKYLAKMEREKAEARLNATSDEESVSAATVPKKIPKEEPNDSDSDEEEEEEETTTTTATTGTNGNNDDDDDDDDDDDDSSDE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00095629; iTF_00106964; iTF_00100940; iTF_00104352;
90% Identity: iTF_00095629;
80% Identity: -