Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.6e-15 9.9e-12 44.2 5.6 112 167 9 64 6 70 0.95

2 3 0.00062 3.8 6.2 5.2 218 270 72 122 65 148 0.68

3 3 0.045 2.8e+02 0.0 1.6 129 169 128 168 112 178 0.54

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.6e-15	9.9e-12	44.2	5.6	112	167	9	64	6	70	0.95
2	3	0.00062	3.8	6.2	5.2	218	270	72	122	65	148	0.68
3	3	0.045	2.8e+02	0.0	1.6	129	169	128	168	112	178	0.54

Coding Sequence: GAGGTACGGGACTGCTACCGCGCCGAACGGGAGGAGCTCATCTACGAGGTGGAGCTCCTCAAGGACTCCCAAACGGAGTCGGAAGAAGCGCACTCGCAGCTGCAGCGGGAGCATCGAGAAAAATGCAAGGAGCTCGATGCGACCAAACGCGATCACGTCAAGATTGCGGAAGAGCTGCGGCTCGTTCAGGGNNNNNNNNNNNNNNNNNNNNCAGCCGGTACACTCGACGACTTTCTGAAACCggtcacaaaagaaaaggagaagctgGAGAATCGGCTGGACGCTGCCCAGCAGGAGCTCCAGGAGCTACAAACCAAGATGCAGCAACTTGGCTTGGATTACTAcggcgagctgctgcagcatgaCGAGTTGCAATGGCAAGACGTGAAGGAAGCCGTCGAACATTATAAAAACTGTGCCAaacaaaaggagaaagaaaactaTCGACTCCACAACCAGCTCATAGAGACTCGCTCCTATGCGGAGAAATCCGCGGAGCAGTTTGAGATCGATCGCCAGAAGCTTCTGCGTGAGG
Protein Sequence: EVRDCYRAEREELIYEVELLKDSQTESEEAHSQLQREHREKCKELDATKRDHVKIAEELRLVQGXXXXXXXAGTLDDFLKPVTKEKEKLENRLDAAQQELQELQTKMQQLGLDYYGELLQHDELQWQDVKEAVEHYKNCAKQKEKENYRLHNQLIETRSYAEKSAEQFEIDRQKLLRE

Sequence clustering based on sequence similarity using MMseqs2