Basic Information

Gene Symbol
rst2
Assembly
GCA_035222095.1
Location
JAWWEA010000038.1:12937215-12953688[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.87 2.7e+02 4.5 0.2 1 23 46 68 46 68 0.94
2 14 0.067 20 8.0 0.8 1 23 82 104 82 104 0.97
3 14 1.1e-05 0.0035 19.9 1.4 1 23 110 133 110 133 0.98
4 14 0.42 1.3e+02 5.5 0.8 1 19 296 314 296 316 0.94
5 14 0.0018 0.56 12.9 0.3 1 23 430 452 430 452 0.98
6 14 7.9e-06 0.0024 20.4 0.9 1 23 461 483 461 483 0.98
7 14 0.00031 0.094 15.4 1.4 1 23 489 512 489 512 0.97
8 14 0.00069 0.21 14.3 1.9 1 23 915 938 915 938 0.97
9 14 0.00089 0.27 13.9 0.3 2 23 1206 1227 1205 1227 0.97
10 14 1.7 5.3e+02 3.6 6.6 1 23 1233 1256 1233 1256 0.97
11 14 0.0086 2.6 10.8 1.5 1 23 1297 1321 1297 1321 0.97
12 14 1.5 4.6e+02 3.8 1.8 1 23 1403 1428 1403 1428 0.96
13 14 0.097 30 7.5 0.2 2 23 1473 1494 1472 1494 0.94
14 14 0.0043 1.3 11.8 4.1 3 23 1502 1522 1500 1522 0.98

Sequence Information

Coding Sequence
ATGGACGTTAAGGTCATTAGGAGAGAACCGGCATCCACTACagTGAATCCAAAGATCGGACTCTTTCAGACACACAGCAGTGAGACTCAAACTAAGATTGCATCATCGCTATTGattgacCAATCAGAAGAATCGCATCCCTGTCCAGCGTGCACCTCAATCCTCCCAACAGTTCGGGACTTAACAAACCACCTGCGAAACCATAATTCGCCACGAAGTATCGACTGCAGCGTCGACGAAGAATTCAGCTGCAGAGTATGTTGCAAAGTATTAAGTTCGGCCAGTTCCCTAGACCGTCACGTTCTCGTGCATTCCGGTGAGCGTCCCTTCAAATGTAAACAGTGCGACATGGCTTTCACCACCAACGGAAACATGACTAGACACTCGAAAACAGCTCACAATCATCTCTCACCAAACAGCTGTTCAGATTCTGAAGCCAGCAATGATTCAGAATCGCCCTCCAAAAAATTCGAGGAATACAATAACAACGAAATCGCCAAACGGAACTCGCCTGACCTCATCGACAAACTAGAGTCTCCCACTTTCATCAAGAAGAGGAAATCCCTCGACTACACAGAGGATCTTAGCttgcagaaaaaattcaaaacaagctTAGATAACCAGAACTACAACTGTCATTCTGATTTCGATAAATGCGAACCCGACAATTTATCGTTCAAAAACCACAGAGTTCTGAATCTTCATCGATCAGAGaacaattttaacgaaaattcccTTAGGAATGTCACGAGGACCTTGAGACATTCGGTTGAAGGTTTTAGAGATCTAACATTCGTCGACTTCACATCGACAAAGTACCCTGTCATCGCGAGGGCGAAATGTGAAGAGTTTCTCCATCGACCAACATCCGGGGACATGGCGAAGTTCCAGTGTTCGAAATGCCTCCGGGCTTTCCCTTGTAAATCAGCATTGGAGTCTCATGAACTGGACTGTGGACTTCCGAATATTCAATGGAAGGGGAATGACGTTCAATCCAGAAGGGATGATTTTTTTGCAGGACTCAATTTACAAAACAAGGCAGCCATGACAGAAGCTAAAGAGGGAAAAGACCTTGCTGATATCCAGAGCATCATTAGTCTCACCTCGAGTCCAATCCTTCACAACTTCTCCAGATCCGATGCGAGTACTCCTGACAATTGCAGTAATAAAATCAACCAGAATGTTGGTTCTTCTGGATCATCAGGAACCCTTTCTTCGGAGTACCACGAGGAAGAAACACAAGATGCTTTTGCAGCCGAGTTCAGAAAAATGAAGCTCAAGGGTGAGTTTCCTTGTAAACTTTGCAAGGAAATCTTTCCCAACTTAAGAGCCTTGAAAGGCCACAATAGAACCCATTTGGGTGTTGGACCTGGAATGCCTTATCCATGTAACATCTGTCCTTATACGAGCACTGACAAGACAACCCTTACGAGGCATCTGAAGACACACAATGGTGATAGACCCTTCGAGTGTGCTGAGTGCGGCTACGCCTTCACAACAAAGGCCAACTGCGAGAGGCATGTGAGGAATCGACATGGAATTCATGACAAAAATGATGTTCAGAAGATGATCATTTATCACCCGACTGAGGATTCTACGAACGAAAGTTTGGATAGAACATCATCGAGAAGTGTGAAAGATGAAGTAAGGAAGGCTCTTGTTTATCCCAAAGAGGAACCACTTCCCCAGAATCATTACTCTGTTATGATGCAACCAGACATTAGAATAAAGGAGGAAAGCAAGGTCATTAAAGATATGAGTCCCATAAGTCAGCTAAACCAAATGAATCAGCTGAACCAACTTAACCAGCTGAGCCACATAAGCCAAATCAATCAACTAAATCAAATAAACCAAATGAACCAGATAAACCTTCAAATGAGCCACTTTGAAAAATCGGAGGTGTTCCCCAGGCCAAAATCAGTTCAACCTCTCGAGTTGACCTACAGAACTTCCCCCCAACATCTAATCATGAAGTCTGAAAATGCCAGGATAGATGAAGATCTTGAGTCAAGGTCATCAGAGGACAGCGTATCTCTAGTCAATGAAACCAAACCGGACATACACCAAAGAATACAAGCTAGTCCGATGAACTTGAAGAAGGTCGCGAATGATTCCTCCAACGTGACTTCGAGCGATGATGGGCCCCTGGATCTCTCGATGGATGTTCTTGATCTGAGCAAAAAATCCAAACAAAAGCCAGAAATAAACGAAAATTCCGATGAACAGAATGAAAACCAAAAGGACTTTTACAACGCTACGAATCCTCTCTTGCTGACACGAGCTTTATTGAAATCTCGTCAGGTTTCCCCTCCAACTTCCTTGGAAGCTCTGTATGCCAATGCACATGCGAACATGATCTACAGCAACTTGGCTCTAGGATCAGCCGGTGCAGGACTGATAGCACCTTATTTCTTCAATCCACTTTTTGATCAAGGTTACGTGATGAAAGAAAGATTACAGAAGGAACTGGCTAGAGGTCTTCAAACTAGCGGTGGCACTTTGGTCGAGCAGCCACTGGAAAATACAGGATTCAATACCAGCTATCCTCCAGGAAGAAATTCACAACAACTCGATGAACAGATGAACTATTCAAACCTGATGCAGCCAAAAGTCCCGAGTAAGGTAATCTCAACCAGAGAGAGAATCAGCGAATCCCCGTCGCCGAATTCTGTTAAAATGGTCATTAAGAATGGTGTCCTCATGAGGAAGCAGAAGCAGAGGAGGTACAGAACTGAGAGACCTTTCACCTGTGAATATTGCTCAGCAAAGTTCACACTCAAAACTAATATGGAAAGGCATATAAAACAACAGCATAATGCCTTGTGGCATCGAAGACCTAGAGGTGGACATTCGACGAGAGGTCGACCTCCAGCGAGACCTCAAGCGAGACCTCCAGGGCTGATTCAAGATGTAGGCCAGGTTTCTCAGGCCTTCCTGAACAGAAGCTCTCCCTATGAAGTTCCATTGCAGAAAGAGGGTCAGTCTGATTATGGAAAGCATTCTATTTCTGACCAGGTCAAGTATGCAATCCTTGCTCAGCAACTGAAGGGAAACAGGCCAGAGGAAAATGAAACTGATGAGGAGTTGATCATCGATGAAGAACCTGGTGCAGAGCCCCGAGATCATACAAAAACGATGAGCTTATTAAGAGGGAAGCTCGAAAGTAATTCAGATGTTAGAGAACAAAAAGAAGATGACATACATGCTCCTGAACACCCTCTGGATCTCAAAAGTGAAGCACCGGAACAGAAAGAGGCCCCTTCTGATGACGAAAACCCCGAAAAAAGAGGCGCTTCCGAAAGTGAGACGAATTCTCATGATGCGACTGAATTGGAAACTCCAGCAAATGAAGGGACCGTGAAAAACGAAGACGAGGCTGTGGATCTTGCCAGTGTTCCCAAACTAATTCACAACGCCTCTCAAAATTACCATCAATTCAAATCTCAGTATTTAAGTGACGAAGATGGCGCCGCTCACTCCAATAGTGATCACTCTGGAAACCATTCCGGGAGTGATGAGAAATCGGAGAACTCTGCTATTTCGACATCTTCCAaaaggaaaaagaagaagaagaaaaagaaggctTCTGCCTACTCCATGGCACCTAACAGAGTAGAATGTAAATACTGTAAACGAGCATTCCCCTGGATTTCTTCATTAAGGAGGCACATTCTCACCCACACTGGAGTCAAACCATACAGATGTGAGCATTGCATGTTGGATTTTACGACAAAGTCTAACTGTGATCGTCACCTGAACCGGAAACACAAGAGCCTTCTTCAGCGAGCAAATGCTAGAAGCACCAGAAATTCTTCCTCACCTGATGGCCAAGACATGAGGGTAACGAATAACAATACTTTCTCGACAAGGAACGTTCCAGAGAGACCCTACAAGTGCAATCAATGTCCTAGTTCCACTTTCGCGACCTTGGGAAATCTGAAGAAACACAGGTCTACAAAACACTCCAGAGAGACGAATTCTAGGTCTGAAACTTCTTCTAGTGATCCTCAACATTCTGATAACTGTCAGAAACAGAACGATCAGAGTGGAGATGACGGTGGATCTTCGAGTTCGGAGAACATGGAGAATTCATCTGCTGGGGTCGAGGTTTCCAAGTCGTGTCAAAACCCTTCCTCTTCGACGAATGAGAATCTAAGGTCCTGTAGGACTTCACCAAGGTCTTCACCTGGACCAACAGACACGCCCTTCAAGTGTCATATTCCGAATTGCGATAATGGGTTCGCTGATCGCCAGGACTGCTTGGATCATATCAAGATGAATCATGAGCGAGACTATGAGATCCTAGTTTCGAAGGGTGCTCTGCAGATGGGGATTCATGCTGCTGAGGAACAGCCTCCACCGACTCAGCACTCGAGCGATGGTCCCAGGTCCCTTGACTACAAGGATAGAAAGGTGGTCTGTGCATTCTGCATGCGTCGATTTTGGTCAGCCGAAGATCTCCGACGTCACGTAAGAACCCACACAGGAGAAAAGCCCTTTTGGTGTGATATCTGCGACCGGAGATTCACCCTAAAACATAGTATGCTACGTCACCGGAAGAAGCACGAAGCAGCGGACTCAACAGTCTACCCTGGAAGCGGCGACGAGGAAATTTCCCCAACACACCCTTCTACAATCACTCCCAGAAGTCAGCAGCAATCCCCAGCTTTAATTGCAGCGACCTCAGGAAGTTCAATGAGCCATGAAAGAATGTCCTTGCCAACAGTAGCGACTGTAGCTACCGGAGATGCTGCACCTAGTGGACTGATGAGGTTCAACCCCTACGAAAAACTGACAACTTTAACTGGGAAATTATCCCAGCAAAGCAACCCTGACGCCGCTGAAACTGGCAATGActtgatttcaaatttactgGGAATCAAAGATCCAGGCATTGTTGACAAAATGCTTCTTGCAACTCCTGATGACGCCGCCAAACTTTTGGGTGTCAAAGGCAACGAGTGA
Protein Sequence
MDVKVIRREPASTTVNPKIGLFQTHSSETQTKIASSLLIDQSEESHPCPACTSILPTVRDLTNHLRNHNSPRSIDCSVDEEFSCRVCCKVLSSASSLDRHVLVHSGERPFKCKQCDMAFTTNGNMTRHSKTAHNHLSPNSCSDSEASNDSESPSKKFEEYNNNEIAKRNSPDLIDKLESPTFIKKRKSLDYTEDLSLQKKFKTSLDNQNYNCHSDFDKCEPDNLSFKNHRVLNLHRSENNFNENSLRNVTRTLRHSVEGFRDLTFVDFTSTKYPVIARAKCEEFLHRPTSGDMAKFQCSKCLRAFPCKSALESHELDCGLPNIQWKGNDVQSRRDDFFAGLNLQNKAAMTEAKEGKDLADIQSIISLTSSPILHNFSRSDASTPDNCSNKINQNVGSSGSSGTLSSEYHEEETQDAFAAEFRKMKLKGEFPCKLCKEIFPNLRALKGHNRTHLGVGPGMPYPCNICPYTSTDKTTLTRHLKTHNGDRPFECAECGYAFTTKANCERHVRNRHGIHDKNDVQKMIIYHPTEDSTNESLDRTSSRSVKDEVRKALVYPKEEPLPQNHYSVMMQPDIRIKEESKVIKDMSPISQLNQMNQLNQLNQLSHISQINQLNQINQMNQINLQMSHFEKSEVFPRPKSVQPLELTYRTSPQHLIMKSENARIDEDLESRSSEDSVSLVNETKPDIHQRIQASPMNLKKVANDSSNVTSSDDGPLDLSMDVLDLSKKSKQKPEINENSDEQNENQKDFYNATNPLLLTRALLKSRQVSPPTSLEALYANAHANMIYSNLALGSAGAGLIAPYFFNPLFDQGYVMKERLQKELARGLQTSGGTLVEQPLENTGFNTSYPPGRNSQQLDEQMNYSNLMQPKVPSKVISTRERISESPSPNSVKMVIKNGVLMRKQKQRRYRTERPFTCEYCSAKFTLKTNMERHIKQQHNALWHRRPRGGHSTRGRPPARPQARPPGLIQDVGQVSQAFLNRSSPYEVPLQKEGQSDYGKHSISDQVKYAILAQQLKGNRPEENETDEELIIDEEPGAEPRDHTKTMSLLRGKLESNSDVREQKEDDIHAPEHPLDLKSEAPEQKEAPSDDENPEKRGASESETNSHDATELETPANEGTVKNEDEAVDLASVPKLIHNASQNYHQFKSQYLSDEDGAAHSNSDHSGNHSGSDEKSENSAISTSSKRKKKKKKKKASAYSMAPNRVECKYCKRAFPWISSLRRHILTHTGVKPYRCEHCMLDFTTKSNCDRHLNRKHKSLLQRANARSTRNSSSPDGQDMRVTNNNTFSTRNVPERPYKCNQCPSSTFATLGNLKKHRSTKHSRETNSRSETSSSDPQHSDNCQKQNDQSGDDGGSSSSENMENSSAGVEVSKSCQNPSSSTNENLRSCRTSPRSSPGPTDTPFKCHIPNCDNGFADRQDCLDHIKMNHERDYEILVSKGALQMGIHAAEEQPPPTQHSSDGPRSLDYKDRKVVCAFCMRRFWSAEDLRRHVRTHTGEKPFWCDICDRRFTLKHSMLRHRKKHEAADSTVYPGSGDEEISPTHPSTITPRSQQQSPALIAATSGSSMSHERMSLPTVATVATGDAAPSGLMRFNPYEKLTTLTGKLSQQSNPDAAETGNDLISNLLGIKDPGIVDKMLLATPDDAAKLLGVKGNE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00677055;
90% Identity
iTF_00201048;
80% Identity
-