Basic Information

Gene Symbol
BRCA2
Assembly
GCA_952773225.1
Location
OX731550.1:18874980-18880381[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 0.68 3.6e+03 -1.7 0.0 2 52 26 75 25 81 0.71
2 6 0.00021 1.1 9.5 0.0 2 54 87 138 86 144 0.91
3 6 0.00014 0.72 10.1 0.0 2 54 148 199 147 205 0.90
4 6 0.55 2.9e+03 -1.4 0.0 2 54 209 261 208 266 0.70
5 6 0.0018 9.4 6.6 0.0 2 53 271 322 270 329 0.83
6 6 1.7e-05 0.088 13.1 0.0 2 54 333 384 332 391 0.91

Sequence Information

Coding Sequence
ATGGTAGAGAATACGAAGAATGTAATGTCATCGATTGGTTTCACAACTGCTGGTGGTAAATCAATTAATGTGTCGGAAAAGGCTTTATCACAAGCAACGCAGTTATTTGCAAATGATTTTGAGGACAGAGATAGACACCTTGCAGTTAAAAATGTACCACCAGAAGAATTGCTTTCCGAAGGAAGGGTAGAGAATACGAAGAATATAATGTCTTCGATTGGTTTCACAACTGCTGGTGGTAAATCAATTAATGTGTCGGAAAAGGCTTTATCACAAGCAACGCAGTTATTTGCAAATGATTTTGAGGACACAGATAGACACCTTGCAGTTAAAAATGTACTATCAGAAGTATTGCTTTCCAAAAGAAAGGTAGAGAATACAAAGAATGTAATGTCCTCGATTGGTTTCACAACAGCTGGTGGTAAATCAATTAATGTGTCGGAAAAGGCTTTATCACAAGCATCGACATTATTTGCAAATGATTTTGAGGACGCAGATAGAGACCTTCCAATTGAAAATGTACTACCAGAAGTATTGCTTTCCAAAAGAAGGGtacagaataaaaaaaatgtaatgtccTCGATTGGTTTCACAACTGCTGGTGGTAAATCAATTAATGTGTCGGAAAAGGCTTTATCACAAGCATCGACATTATTTGCAAATGATTTTGAGGACACAGATAGACACCTTGCAGTTAAAAATGAAGTACTAACAGAAGAATTGCTTTCCGAAGGAAGGGTAGAGAATACGAAGAATATAATGTCCTCGATTGGTTTCACAACTGCTAGTGGTAAATCAATTAATGTGTCAGAAAGGGCTTTATCACAAGCAACGACATTATTTGCAAATGATTTTGAGGACACAGATAGACAACTTGCAGTTAAAAATGAAGTACTAACAGAAGAATTGCTTTCCAAAAGAAGGGTAGAGAATACGGAGAATGTAATGTCCTCGATTGGTTTCACAACTGCTAGTGGTAATTCAATTAATGTGTCCGAAAAGGCTTTATCACACGCAACGCAGTTATTTGCAAATGATTTTGAGGACGCAGATAGAGACCTTCCAGTTGAAAATGTATTACCAGAAGTATTGCTTTCCAAAAGAAGGGTAGAGAATACGGAGAATGTAATGTCCTCGATTGGTTTCACAACTGCTAATGGTAATTCAATTAATGTGTCCGAAAAGGCTTTATCACAAGCAACGCAGTTATTTGCAAATGATTTTGAGGACACAGATAAATTCAATGAAATGGATATAACTGTTAGACAGATTGATAAACCTGAAATGCAAGTAGAAAACATTAGGTTCCAAACTGCGACCGGCCGAGGCGTTACAAAGGAGGCTTTATTAAAAGCAAAATCATTAGTCAGCAAAgtatcagaaaattttggaagcAGTCCTGCATTAACAAAGTCCGTGCAGAAACGTAAAATCAAGGATTTAGATGACGATGTACCATTAAAGAAACAAGTAACATCTAATCACTTTAAGAAGTTGCGATTTAGTAATGGGTTTGAAAGTCAAAGAAATACCAGCaaggatttaaaaaataatgcaaaCAATGAAAATCAAACAGCGCCTTCAACGACAACCGAGGTTTCAATTGCGAATAATACCGTGGATAAATCGATTGATAATATTTATAGAACTGAAAGAAGCAGACAGAATAATGATACAGATAATTCcttaatttcaaatgaaattgtaGCAAGTACAGTGGCACTTTTAGCCGACGAAAATAGTTCAGGCATTGTCGATCACTGGCCTTCTCCTGTACAGAGTATAGAAACCAACGATGGTGCAAATGTACCATCCAGTCCTGTAATAGGAGGGCACTTTATTCCTAGAAAACAAAAGAGTGGTCGAAAGAAAAGTATAAATGCTTTACAAACTACAGAACACAAATCTGTCTGTAAACATGATTTAAAAAGATTGAATCTTAATTATGAAAGTTCAGATCAGTCTACAGGAAAGAAACATAAAAGTTTAACAGAAGAGCCAGAGCGTGTGGATACAGAAAAGAAATATGATACTTTGGTTACCACTGAATTTGGTGATAGTCAATTATTGATGGATTTTATTAATGAATCTGCTAATATATTAGAGAAGCGTTTAGAAGCTGCTTTGGAACAAGATAAACAAATTACTTTGAAAAAGAAATCTAAACCAAATCCAACAATCAGTAAACTATATTTTCACAGAAAGAGCAATCGTAATAATCGTGTATCTTGGAAAGAAATCAGTAAAGGAAATGTGCCTGTTCCATGTACATATAAAGAGCTTATCCAGCGAAAGTTACCACCTGAAATTTTGGACGTAACTGCTAATAATGCTATAACGTATAAATTTCGATGTGCAGATTTTTATGGACAAGACATTGTACAAGATAATATTGAGGGTATAAAATTAGAAGATGGAGGATGTCTGATTCTGGATGAAAATAGCTACGTGGGAATATCAGAAATTAAGCGGTCCTTCTTAGCGAGTCCAGGAGTGGATCCCGATTTGCTTTCTGCTGGGTGGGtggaaaatcattacaaatggaTTGTATGGAAGTTGGCATCAGTGGATAGAATAAAATTTGGATCTGAAATTTTATCGAGAGCATTGACTCCTGATAGAGTAATGAGGGAATTGAAATATCGTTACGATCGGGAAATTGATAGATCTGAGAGACCAgcattaagaaaaattttgGAGAAAGACGATGTTGCGTCTAAGAGAATGGTTTTATGTGTATCATCTATTATTGagTGCGATGATTCTGCTTCTACAAGCAAAAGTCCAAATCAATTGAAAATGCCATCAAAGCGACTAATATTAACAGATGGATGGTACAGTGTTCAGGCCTCTATTGATCAAGCAatgattaaaaatataatatccgGTAAATTAAAGGAGGGAACGAAACTAATGACATATGGGTCTGAATTGTTAAATTGTGACCAAGGATGCTCACCATTGGAAGTTCCGGAGAATGTATGCTTAAGAATACACACAAATTCTACGAGAAGAGCAAGGTGGGATACAAAATTAGGATATGTAGTACCTTTAGGACCGATGTGTATAAAATTAAGGGACATTTGTTCGACTGGCGGTTTAATTGGGAAAATTAAAGTGTTGGTTGCACGTGTCTATCCAGTTTTGTATCACGAGAAAACTGTAGCGGGGGAGTCTATCGTTCGTAATGCGAGGTGCGAAGAGAAAGCTGACATCGCTTATAAGAAAGAACGTCAATCAAAAATAGAAGCATTCTATGCGGAATCCGAGGCGTATTTCTCCGAAGACGGGAGAAAAAACAATACGAAGCCAGATAGCTTCGATTTAGCAGCAATTGAGTGGAATGAACATCGTGAAAAGTTGTCTAATAagAAATTTCATTCGAAACAAGAACAGCAGCAATTAATAAACAAATGTCGTATGGAAGAAGAACAGCTTAGGAAAAAATTAGAATCTCGATTACAGGCAAGTTTACCAAAGCCTCGGAATGTCACGCCCCTTTTAAAAGTTCGAGTAATCGAAGAAAATACAAGTGTCATTCTTTCTCATTGGTCTCCTAGCGAAGAAGTTACGGATCTTTTCAAAGAAGGAAATTACATATCAATTTGTAATCTTACGCCCTCGTGTAGAAGAGGTAGTGAGCTGCAATTAACTGCAGGTCGAAGCGCAGTATTTAATCAAATCAATAATTCTAACATAATTTATCCGCGAAGATCATTTACACCGCTATGTGATGTAAACAAACCTACTTTTACTCCACCATATGGAGAATTTGATACAGTGGGAATTGTCGTCTCTATTGCGAATGAACCATACGGTATGAAAAATTTTCAAGCTGCGTATTTGGCATATCCCAATGCAAATTCTCAGTCTTCGTATTTGTCGGTGCTATTTTGGCAAGGAATATCTTCCCATGGGTATGCAGAAATTTTGACCGCGGGATCTTCGGTTGCTTGTAGCAATTTAGAATGGCGACGAGCCACATCGTGGAATATACAAATGTCATATTGCACAGAGAGAAGTGCTTTCACGCGAAATCCTCGTCAGAATCATCTTCAACAGCCATTCAACGATTTGAAACGTTTAATCACAGACACCGCCGAGTACGTAGCTATGTGCGGGGCAGAAATTTCTGAGGAAGCGCAAAAGAAGTCTACGACGAGAATGTCAGACCAATACACGCCAAATAAGATTCCGTCTAACGATAGCTTTCACTCAGATAAACAAATTGGTAATTGTCCGGTTCAAGAATTTTCAGGGAGAAGTTCAACGACAGCAAGGTCCGTTGCGATACAGAAACGGCTTGAAAAGCTACACTACTATGGGGAACCATCGGGCTTGTCCCCGATTGTGCTGAATAACAGTTCCAAGAGAGTGTCGTTAGATTTTCAGTCTCCCGTTCGCAAAGTGGATGCGAAACAATCGAAAGTTCATGTATCattaaattcaaaattttcacaGAATCCCACATGA
Protein Sequence
MVENTKNVMSSIGFTTAGGKSINVSEKALSQATQLFANDFEDRDRHLAVKNVPPEELLSEGRVENTKNIMSSIGFTTAGGKSINVSEKALSQATQLFANDFEDTDRHLAVKNVLSEVLLSKRKVENTKNVMSSIGFTTAGGKSINVSEKALSQASTLFANDFEDADRDLPIENVLPEVLLSKRRVQNKKNVMSSIGFTTAGGKSINVSEKALSQASTLFANDFEDTDRHLAVKNEVLTEELLSEGRVENTKNIMSSIGFTTASGKSINVSERALSQATTLFANDFEDTDRQLAVKNEVLTEELLSKRRVENTENVMSSIGFTTASGNSINVSEKALSHATQLFANDFEDADRDLPVENVLPEVLLSKRRVENTENVMSSIGFTTANGNSINVSEKALSQATQLFANDFEDTDKFNEMDITVRQIDKPEMQVENIRFQTATGRGVTKEALLKAKSLVSKVSENFGSSPALTKSVQKRKIKDLDDDVPLKKQVTSNHFKKLRFSNGFESQRNTSKDLKNNANNENQTAPSTTTEVSIANNTVDKSIDNIYRTERSRQNNDTDNSLISNEIVASTVALLADENSSGIVDHWPSPVQSIETNDGANVPSSPVIGGHFIPRKQKSGRKKSINALQTTEHKSVCKHDLKRLNLNYESSDQSTGKKHKSLTEEPERVDTEKKYDTLVTTEFGDSQLLMDFINESANILEKRLEAALEQDKQITLKKKSKPNPTISKLYFHRKSNRNNRVSWKEISKGNVPVPCTYKELIQRKLPPEILDVTANNAITYKFRCADFYGQDIVQDNIEGIKLEDGGCLILDENSYVGISEIKRSFLASPGVDPDLLSAGWVENHYKWIVWKLASVDRIKFGSEILSRALTPDRVMRELKYRYDREIDRSERPALRKILEKDDVASKRMVLCVSSIIECDDSASTSKSPNQLKMPSKRLILTDGWYSVQASIDQAMIKNIISGKLKEGTKLMTYGSELLNCDQGCSPLEVPENVCLRIHTNSTRRARWDTKLGYVVPLGPMCIKLRDICSTGGLIGKIKVLVARVYPVLYHEKTVAGESIVRNARCEEKADIAYKKERQSKIEAFYAESEAYFSEDGRKNNTKPDSFDLAAIEWNEHREKLSNKKFHSKQEQQQLINKCRMEEEQLRKKLESRLQASLPKPRNVTPLLKVRVIEENTSVILSHWSPSEEVTDLFKEGNYISICNLTPSCRRGSELQLTAGRSAVFNQINNSNIIYPRRSFTPLCDVNKPTFTPPYGEFDTVGIVVSIANEPYGMKNFQAAYLAYPNANSQSSYLSVLFWQGISSHGYAEILTAGSSVACSNLEWRRATSWNIQMSYCTERSAFTRNPRQNHLQQPFNDLKRLITDTAEYVAMCGAEISEEAQKKSTTRMSDQYTPNKIPSNDSFHSDKQIGNCPVQEFSGRSSTTARSVAIQKRLEKLHYYGEPSGLSPIVLNNSSKRVSLDFQSPVRKVDAKQSKVHVSLNSKFSQNPT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-