Basic Information

Gene Symbol
topi
Assembly
GCA_030264675.1
Location
JARJDV010001709.1:62319-64895[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.00038 0.035 14.4 2.4 2 21 153 172 152 173 0.94
2 13 1.2e-07 1.1e-05 25.4 0.6 1 23 198 220 198 220 0.97
3 13 0.039 3.6 8.1 0.8 3 23 228 248 227 248 0.95
4 13 2.8 2.6e+02 2.3 0.1 2 12 267 277 266 286 0.79
5 13 0.0088 0.82 10.1 1.1 2 23 353 374 352 374 0.94
6 13 1 97 3.6 6.0 2 22 417 437 416 440 0.86
7 13 1.7 1.6e+02 3.0 0.5 1 23 577 600 577 600 0.94
8 13 0.0039 0.36 11.3 0.3 1 23 604 626 604 626 0.97
9 13 7.5e-06 0.0007 19.8 5.4 1 23 632 654 632 654 0.98
10 13 0.015 1.4 9.4 0.2 1 23 660 685 660 685 0.96
11 13 0.075 7 7.2 2.9 1 23 691 713 691 713 0.86
12 13 1.8e-06 0.00017 21.8 1.5 1 23 719 741 719 741 0.98
13 13 2.6e-06 0.00025 21.2 0.9 1 23 747 770 747 770 0.98

Sequence Information

Coding Sequence
ATGAATCGCAACGAAAACTTTTCCTATTTGAAAATACACAAATTGTTTCCGGACTCTTCGATCAAATCGATGAGACTTAAATTTGAGTGCCGCTCACATCGAGTTCTGAGCAAGATTCCCATATATGTGGACGTGGAGccaatttatgataaattcatGAGGGAAACCCATCCagccaaatttaatttcggcTTAAATTTTAACTTGAGCGGTTCGGAGGTTCGTGTTATTAGATTAGGAAAAGTTGAGGATCTCAACCCTGTTAATTGTACAACAGAAATTCGTACGATGCATAATGATCTCAATGACACATCTAATGCAGTTACGATTTCACAAACCATAACTGATAATGCCCACAATACAAGCTATAAATCGTTGCCAGACGGTATAGAAAAGATTAAGAATCTGACCAGCACAAACCGGGAGTCAAAGGTTCCCAATATCCCAATGATGATTCGTTGTCAAAATTGCGATACAAATTTCCCCACCAAGTACCAATTTCAGCGGCACCAATGCGAATTCAATGCCGAAAAGGTGGTGTTAAAGCCAAATATCGACGTTCGAGATGTGGATAAAGGcatgcgaatgaaatatgattgCGGTACATGTGGAAAGCAATTTGTGAGCAAAAGTAATCTGGAGCGGCATCTCAATAGTCATAATAATGGTAATGCTAATATTTGCGAATTCTGCAGCAAACAGTTTGTTAGCGAAAACCGTTTACGCATTCATAAGGAGAACCATTGCAAAAAGGCTGGGGACATTAGTAAATTCTACCGAAGTGATGTCACCGTTTGGAGGTGTGCTAAATGTTATCAAGTCTTTTCGTCCGACGAATTTGCACTTACTCATGTCAACGAATGTTCGGATGTTGTGTCAGATCCAATCGCAATCAaaaacgcaaatgaaaatatctcatCAGTCTTGTCGTTTAAGGATGGTGTTATGACATCGGTAAGCATGGACCTCCCTGAGGAAGATGTAGAAAATTCAGTTGattatgaaaacaaacaaggGTGTGTGCTGGTCGAAAAGGTTCGGACAGAGTTGTTGCTGCAGTGTGAGTTCTGCAACCGAACATACGCCAATAAAAAATCGTTGGTGTTTCATCAGGATATGCACaatactgaaattaattataattgtataatGTGTAATGCTACCTTCGAATCGTACGTACTTGCAGCAAAGCACTGGCTCACTGAATGTGCAAATGAAGCAAATCTGTTTTACTTACCGAAGTTGATTTACTGCAAATGCTGTGATCGCACATTCAAATCACATGAATTGCTTTATATGcacaaaatgaagaagaagcactACACACCAAAAAAGCATCACAACTTAAATAACGATGCACAGGTTCCGTCCGAATCCCAATTACCCGCTCACGAAACAAATTCAGACATAGCGATTAATCAAGACTGTGATGCGAATAAGGATACTAtgattaaattgattgaagGGGTCCTGTGTTCAATTAATCATAAtcttaatgatgatgaaacacAGTTAAGTCTATTGGGCTCAGAATCAAGCTCCAAACATGACGAAATCAGTGGCAACAACGATGTACTTGGATCTCAAGATTCCAAAAGTTTGCCGAATGTTGGTGATGTGGAACTGACCGAAGAAAATACTGGTAAGAAGAGACGCGGTCGAAAACGCAAACATCCAATACAATCCAAAACGAAACGACCATGTCCCGGTGTTACACCGGGATACAAGTTCCAATGTGAACGGTGCATCAGTGTCTTCGATTCTGTTATTGATCTTGAGGTTCACCGCCACAAGGATCACCCAGCAAATTACAAATGCGAAGAATGTGAGCAAGTCGTTCATAGTTCCAAGGCGTTGATAATTCACAGCAGAGCGCATCAAAGTCTCAAACCATATGTGTGCGAAATTTGCAAACGATGCTACTCTCAGACGTCTCATTTATGGCAACATATGAGGTTTCATCAAGGCATTAAACCATTTGCATGTCCACATGAAGGATGTGAAGCTAGATATACGATTCGTCCAGATCTTAAAGACCACATTCGAAAGGTGCACACCCGTGAACGACCCTTTAAGTGTTCCGTTTGCGATAAGTGCTTTCTAACTGGTTCAGTTTATTATCAGCATAGATTAATCCATACAAATGATCGAAGATACGCATGTGATatTTGCCATAAACGATTCTTCCGTGCAGATGCGTTGAATAATCATCGTCGAATTCACACTGATGAACGACCCTATCCCTGTAATGTGTGCGGTCGCAATTTTAGACAAAAAGGAGATCGTAATAAACATGTGAGGACTCAGCATCCTGCCTATGCATGA
Protein Sequence
MNRNENFSYLKIHKLFPDSSIKSMRLKFECRSHRVLSKIPIYVDVEPIYDKFMRETHPAKFNFGLNFNLSGSEVRVIRLGKVEDLNPVNCTTEIRTMHNDLNDTSNAVTISQTITDNAHNTSYKSLPDGIEKIKNLTSTNRESKVPNIPMMIRCQNCDTNFPTKYQFQRHQCEFNAEKVVLKPNIDVRDVDKGMRMKYDCGTCGKQFVSKSNLERHLNSHNNGNANICEFCSKQFVSENRLRIHKENHCKKAGDISKFYRSDVTVWRCAKCYQVFSSDEFALTHVNECSDVVSDPIAIKNANENISSVLSFKDGVMTSVSMDLPEEDVENSVDYENKQGCVLVEKVRTELLLQCEFCNRTYANKKSLVFHQDMHNTEINYNCIMCNATFESYVLAAKHWLTECANEANLFYLPKLIYCKCCDRTFKSHELLYMHKMKKKHYTPKKHHNLNNDAQVPSESQLPAHETNSDIAINQDCDANKDTMIKLIEGVLCSINHNLNDDETQLSLLGSESSSKHDEISGNNDVLGSQDSKSLPNVGDVELTEENTGKKRRGRKRKHPIQSKTKRPCPGVTPGYKFQCERCISVFDSVIDLEVHRHKDHPANYKCEECEQVVHSSKALIIHSRAHQSLKPYVCEICKRCYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCSVCDKCFLTGSVYYQHRLIHTNDRRYACDICHKRFFRADALNNHRRIHTDERPYPCNVCGRNFRQKGDRNKHVRTQHPAYA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00049445;
90% Identity
-
80% Identity
-