Basic Information

Transcription Factor Domain

TF Family: AF-4
Domain: AF-4 domain
PFAM: PF05110
TF Group: Unclassified Structure
Description: This family consists of AF4 (Proto-oncogene AF4) and FMR2 (Fragile X syndrome) nuclear proteins. These proteins have been linked to human diseases such as acute lymphoblastic leukaemia and mental disabilities [1]. The family also contains a Drosophila AF4 protein homologue Lilliputian which contains an AT-hook domain. Lilliputian represents a novel pair-rule gene that acts in cytoskeleton regulation, segmentation and morphogenesis in Drosophila [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 7.6e-07 0.012 14.7 14.1 4 120 7 123 5 129 0.69

2 3 1 1.6e+04 -7.4 12.3 256 291 106 138 85 144 0.61

3 3 6.5e-07 0.011 14.9 1.1 317 395 197 273 176 287 0.73

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	7.6e-07	0.012	14.7	14.1	4	120	7	123	5	129	0.69
2	3	1	1.6e+04	-7.4	12.3	256	291	106	138	85	144	0.61
3	3	6.5e-07	0.011	14.9	1.1	317	395	197	273	176	287	0.73

Coding Sequence: ATGGAACGTGGCAGtGTGGAAAGGGACCGCCTTCGGGAGCGGGATCGGCTCGCTCGAGCTCAGATGTCATCCCAGAGCGCCGAGCCGGAAACCTCACGACCGCTCTTCAGCGATCCGGTGCGGGTGAATCCGTCCTCCACGGATCCTTTGTCGCAGGAGATCCAGAGCCAGTTGGGCGACTTCCAAAAGGTGAAGCTGTACCTTGACTCGAAGCTCATCGGACCAGATGGCGGTAACGCGACGACCAAGGCTCAGGGCGAATTCAAAAAGCCGCAACTGAACGGCAGCAGTGGCAGCGCCtgtggcggcggaggcagtagtagtagtagcagcagtagcagtgGCAACCGGCCGCCGTCGCACCATCAATCGTCGTCGAACGTGCGCGGCGGCTATGTCAAGCCCATGGACGGCAAGCCGCCACACGAAGGCCGCGGCTCCTTCTCTGGCCAGCCGGTCAAGCACGGCAACGCCATCACGAGTCACAGGTCGAACGGCATGTTGCCGGCGAAGggtccaccgccgccgacgtcaGCATCGTCTACCTCACCTGTGGCTTCCAATGCGTCCGCCAATCGTCCGCACAACCTAGCCGCCGGTCGCGCCGCCTCCGGCAGTTCGCTATCATCCGAACAGATCGGCGGGCCAGTCAGGGATAGTCAGTCGACGAGTCGAAGGGTTGAGCGAATTCTCAAAGAAATGATTGACGTCGGACCACCCTTATCAGCTATTGCAGCGACACCGCGTGTAGAACTGGACAGCAAGTATACGTTTAGCACACAAGACGTTGCAAagtTATCGGAACCGTCGATTGTTTCCAATGTCAACAGCAACAATTCAAAGAGTGAGTACTATTTTACTATTCGACCATCCTTTTGA
Protein Sequence: MERGSVERDRLRERDRLARAQMSSQSAEPETSRPLFSDPVRVNPSSTDPLSQEIQSQLGDFQKVKLYLDSKLIGPDGGNATTKAQGEFKKPQLNGSSGSACGGGGSSSSSSSSSGNRPPSHHQSSSNVRGGYVKPMDGKPPHEGRGSFSGQPVKHGNAITSHRSNGMLPAKGPPPPTSASSTSPVASNASANRPHNLAAGRAASGSSLSSEQIGGPVRDSQSTSRRVERILKEMIDVGPPLSAIAATPRVELDSKYTFSTQDVAKLSEPSIVSNVNSNNSKSEYYFTIRPSF

Sequence clustering based on sequence similarity using MMseqs2