Basic Information

Insect: Anastrepha fraterculus
Gene Symbol: MBD-R2
Assembly: GCA_037575425.1
Location: JAYXIM010045293.1:292175-296012[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 4.3e-21 3.9e-17 62.9 0.1 4 76 408 478 405 479 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	4.3e-21	3.9e-17	62.9	0.1	4	76	408	478	405	479	0.93

Sequence Information

Coding Sequence: ATGGGTCGCCGCTGTTGTATTGCCGGTTGTAGCTCTACTTCCCGATTACCAGAACATCATGGTGTCACATATCATTCGTTTCCTTTGGATCCAAGCATACGGTCCGTTTGGCTACGCAATACGAGACTTAGTGCCGAACGGCAAATAACTAAAAGTGTACTTGTGTGTTCGAGACACTTTCGTCGAGTAGACTTCCAGCCACAGCGCAGCGGAAAGTATTTACTAAAACAACGGGTGTTTCCTACTGTATTTCCATGGGGTAAGGTCGATCCTACTCAGGTGGAGTCTGATTTAGAAGATTTGAAAACTACTGCTTTACCTACGAGTACAACCAATCAAATAAGTGAAGATGCTACGAAAGCTACAGTAGAAGCAAAGGTTGCTCAGATAATGGCTGAAACAGCAGTGCGTAACGCTGTAAAAGCATGTATAGTTAAGGACGACAGTGAAACTGCTTCAGCTGCCACAACGCCGGTTTCTGCATCTCCAGCTGCAGTAAAATTTGAGCCGGTAACATCGTTTAATTCTGGCACACGACTTGAAGCGCAGGATTTCGATGGTGTTTGGCATGCAGCCCGTGTTGTCGAGGTGGATAACGATGATCGTGAGGTACTAATAAAATTCGAACGTTCGGGTAAAATGAAATCAGTGGTTGTTGGTACAGAAGAATGGATTCCCATGAATTCGACACGCTTGcggcaaaaaatttcaacaaagccAATACTAGTTTTTGAGTTAGAAGAAAAATGTATGGCACGTTGGTCAGGCCCAAGGAAATTTCCAGgtactgtaaaaaaaatcatcggAAATGACATATACGAAGTTCTATTTGATGACGGCTATGTGAAGAATGTACGTGCATTGCATATGAGCAAAGTTCTGCCTGTGGACGCTGAATCACAACCACCTATTTCCTCAACGACTCTTCCTATTCCCAGTAAAACACAGACACCAACCAACAATTCACAAGAATCTTCATgtgtaaaatcaaaaaaagtcgaATCTCCTTTACCAATACCAACTAGTTCGTCCACTTCTAAGAAACGAACTCCATCGGGCGCTCGAAAGGATTGGCCTTTACTCGATTTGGCAAAACTGGACTTaactACATTAAATTTACCAGAAATACCACACGATGGCGAATGGACATGCCATTGGGTTAATGATCAACCAATTGGACGAGAGGGCTTTCTCATTGTCGGTGAACATCGAAAACCAACAGTAATCGTAGAGGATTGGCGTTTACCACCGGGTTGGGTAAAACATATGTATCAGCGTTCCAATGTGTTAGGAAAATGGGATGTCATATTAGTGACACCAGGTGGAAAACGTTTTCGATCAAAATCGGATCTAAAAGTTTTTCTCGAGGAGCAAGGTCAGATGTACAACCCAGACGTATATGATTTTAGTATTCATCGTCGGCGTGCTAAGGATATAAATGCATATGTTTTTACTCCTGACTACACGCCACAGCAGACACCAAAACCCAAACCTCTGGACACTACAATTGCTGCCATGGATGCGGCTTGTGTGAAAGAAGCGACGACTGTACTTTCTGTTAGTAATTCACAGTATATTGAAACACCAGTGGCCACTCCAGTGCCGCCAGCCGAACTTATGACTCCAACGTTACCCACAGATGACTTACCCACACCTGTTAAAGAGGAACTAGCTGGAAATCTTGATAATGCAACCGCCTCTTCTTCTCGTTCGGCAGATGCACACTTTCCTGCTGAAGATGGTTATGCTTACATAGGTGGACTAAAAGTAGAAATAATCGAAAACCTTTTCCGATGCCCTCAAGAGGGTTGCCTGAAGAATTTCCGCAAAGAAGATCATTTACAAATTCATGTAAAGCATTACCATCAGGACTTAATAAAACTGTTAGGCACGTGTCCGAAGATGCTTGAGCTGGCAGAAAAGCGCACACATACTAAACCCGACCAGCATGAGCCGGCGCCACGTAATCAAATTCCCAATCAGCAATTCTTTGCTAAACTTCATCAACAAGATTTGCTTCAAACTCGAGCACATCGGCGCAGCGGTGGTATAACTGCAGTAACGACAGGCAGTGCCTCTCAAGCTGTAGTGTCTTCTCCCGAAATGAAAAGTGAAACTGAGATCAAGAACGAATCAGATGCTGATCTAGAAATGTCACATATATCTGTCGGCCTCAATGATACTTCGCTTAATAGCTCTGCCCAAAATAGTCAAAATAGTACAATGATGGATATTTCCGGCGCCACAGTCTCATCTGTGGACGAAAATTTGGCCGATATATCGGCAACATCAGCCAAGCGCTCGCGTATGTCACAGAGCAAGCGTTCTCTCGGCTCACGTAAAAGCAATCGCCAGCGTACAACGCGTCGTTACTTAACAGCTGCTCAGGCCACATCAGGTGGATCGCTGCTACCAGTGGTAACCGCTGACAGTAGCTTTGGTGTGTCGGAATTTGAAGAGACACGACACTCCTTCAACGCAACTCCCGATGCTAAAATTGCCGATCTGGGaaagaaacataaattaacgGGTGCCCCAGTTACACCGATGAGCAGTCTAGATTCACCTGTAACTGCCGATTCAGGATCATCATCGTTTCCACCATTATTGGCACCAGGATCTAATGAAACTGAACCTACGGCGGGAACAACTGTTAACCAACCTCAGTACATAAAAGAAAACGGTGAAATCATAAAGATAGTTAGCATGCGCCAGGAAGAAATAATCAATTGTCTGTGCTCATATGGCGAGGAAGACGGCCTCATGATACAATGTGAACTGTGCTTATGTTGGCAACATGGCATTTGCAATGGCATCGATAAAGAAGTTGATGTGCCTGATAAATATGTGTGCTACATTTGCCGCAATCCACAACGCGGTCGGGAGTCAATGCGTTTTAAACACGATCAAGATTGGTTGTATGATGGAAAACTACCGGTGGCGAATTATCACATTGCAAACCCCAATCTACAGAAGCGTttcgattttctcaaaaaatcgcACGTCCTTACTGGTAATTTAGTAGAGCTAAGGCGTTTTATGCATTCACTGCGTATCAAAATGAACATCGTCAACAATCGCTGCCATCCAAAGTTGTACTTGTGGGCTAAAAAGTGGGAGGAAGATTTAGTGTCACAACTTTCCAAGGCAAATATAAAACCCGAGCAAGATATTAAAATCGAAGATATAGATGTTGAAATAAAAGTGTTGGATCAAAAAGAAAAGACGACTCCATCAACACCGcctgcaaagaaaataaaatcggAACCTACCACACCGTCACAACCCATTCCAAATATACCGCAACCGGAAGCACCCATCGATCCAGTCGAATGTCAGCATCGATTAATGGAACACATAAAGATACAGCAAAGTTTAGTACTGAATCGTTTAGACGATATTGAGAATGAAATGGACGAACTGGAATGTCAAGACGATCTTTTCGATTTAAAAGACGGCGATTTTAAGAGTACGAAAGAAGTTTTGTCTACTTTCATTAAAGAGTTGGACGTAATGAAGCAGCTGGCTAAACTAAATACTTTGGAGAGTACTAAACAATCTGTAAAAAACACATTGGCagttaaataa
Protein Sequence: MGRRCCIAGCSSTSRLPEHHGVTYHSFPLDPSIRSVWLRNTRLSAERQITKSVLVCSRHFRRVDFQPQRSGKYLLKQRVFPTVFPWGKVDPTQVESDLEDLKTTALPTSTTNQISEDATKATVEAKVAQIMAETAVRNAVKACIVKDDSETASAATTPVSASPAAVKFEPVTSFNSGTRLEAQDFDGVWHAARVVEVDNDDREVLIKFERSGKMKSVVVGTEEWIPMNSTRLRQKISTKPILVFELEEKCMARWSGPRKFPGTVKKIIGNDIYEVLFDDGYVKNVRALHMSKVLPVDAESQPPISSTTLPIPSKTQTPTNNSQESSCVKSKKVESPLPIPTSSSTSKKRTPSGARKDWPLLDLAKLDLTTLNLPEIPHDGEWTCHWVNDQPIGREGFLIVGEHRKPTVIVEDWRLPPGWVKHMYQRSNVLGKWDVILVTPGGKRFRSKSDLKVFLEEQGQMYNPDVYDFSIHRRRAKDINAYVFTPDYTPQQTPKPKPLDTTIAAMDAACVKEATTVLSVSNSQYIETPVATPVPPAELMTPTLPTDDLPTPVKEELAGNLDNATASSSRSADAHFPAEDGYAYIGGLKVEIIENLFRCPQEGCLKNFRKEDHLQIHVKHYHQDLIKLLGTCPKMLELAEKRTHTKPDQHEPAPRNQIPNQQFFAKLHQQDLLQTRAHRRSGGITAVTTGSASQAVVSSPEMKSETEIKNESDADLEMSHISVGLNDTSLNSSAQNSQNSTMMDISGATVSSVDENLADISATSAKRSRMSQSKRSLGSRKSNRQRTTRRYLTAAQATSGGSLLPVVTADSSFGVSEFEETRHSFNATPDAKIADLGKKHKLTGAPVTPMSSLDSPVTADSGSSSFPPLLAPGSNETEPTAGTTVNQPQYIKENGEIIKIVSMRQEEIINCLCSYGEEDGLMIQCELCLCWQHGICNGIDKEVDVPDKYVCYICRNPQRGRESMRFKHDQDWLYDGKLPVANYHIANPNLQKRFDFLKKSHVLTGNLVELRRFMHSLRIKMNIVNNRCHPKLYLWAKKWEEDLVSQLSKANIKPEQDIKIEDIDVEIKVLDQKEKTTPSTPPAKKIKSEPTTPSQPIPNIPQPEAPIDPVECQHRLMEHIKIQQSLVLNRLDDIENEMDELECQDDLFDLKDGDFKSTKEVLSTFIKELDVMKQLAKLNTLESTKQSVKNTLAVK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00091341;
90% Identity: iTF_00082178;
80% Identity: iTF_00081295;