Afra015566.1
Basic Information
- Insect
- Anastrepha fraterculus
- Gene Symbol
- Runx1
- Assembly
- GCA_037575425.1
- Location
- JAYXIM010020139.1:11985-12521[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2e-52 1.5e-48 164.9 0.0 3 94 80 171 78 176 0.96
Sequence Information
- Coding Sequence
- ATGCATCTCACCACAACGACCAATACCGTCGCCGCCAACAATGCGGGCGCGACCcagagcagcaacaacaatgcaaacAATTCCAGTTCAAATAATAATGGCGGTAGTAATAATACTACAACAAatggcaacaacagcaacaccaatGAACAGAACACACCGCCAACAGCGGCTCAACTGCTGAATGAAGCCTACACGAAGATGACCTCAGATATATTGGCGGAACGGACATTAGGCGATTTTCTCACAGAACACCCAGGCGAGCTGATACGTACCAGCAGTCCGCTTTTCGTTTGCACAGTACTGCCGCCACATTGGCGTTCCAATAAGACTCTGCCGGTCGCCTTCAAAGTCGTCTCACTGGGCGACATAATGGACGGCACTATGGTGACGGTGCGCGCTGGCAATGACGAGAACTACTGCGCTGAACTGAGGAATTGCACGGCCGTTATGAAGAATCAGGTggcaaaattcaatgatctaaGGTTCGTGGGACGCAGCGGCAGAGGTGAGTTGGAATTGACGAGATGTTGTTAG
- Protein Sequence
- MHLTTTTNTVAANNAGATQSSNNNANNSSSNNNGGSNNTTTNGNNSNTNEQNTPPTAAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGELELTRCC
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00966938;
- 90% Identity
- iTF_00080972; iTF_00082706; iTF_00081919; iTF_00189713; iTF_00189715; iTF_00192587; iTF_01045245; iTF_00090942;
- 80% Identity
- iTF_00080972; iTF_00082706;