Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 2.6e-29 7.9e-27 96.2 0.3 3 108 17 120 15 122 0.94

2 4 0.19 58 6.5 0.1 79 107 123 151 118 154 0.85

3 4 8.4e-29 2.6e-26 94.6 0.6 1 109 181 287 181 288 0.95

4 4 0.6 1.8e+02 4.9 0.1 81 108 291 318 285 320 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	2.6e-29	7.9e-27	96.2	0.3	3	108	17	120	15	122	0.94
2	4	0.19	58	6.5	0.1	79	107	123	151	118	154	0.85
3	4	8.4e-29	2.6e-26	94.6	0.6	1	109	181	287	181	288	0.95
4	4	0.6	1.8e+02	4.9	0.1	81	108	291	318	285	320	0.85

Coding Sequence: atgagtgaATCTGAAGCAACTAATAAAGAAGTGAATGTGATTAGTGaaaatctcaTGGAAAATGACAAATTCAGTGATGTATCTCTGACTGTCGGTGAGCAAATATTTCCTGCCCACAAATGTATACTAGCAAACAGAAGTCCTGTTTTTTCAGCAATGTTTGAACATGacatgaaagaaaataaaagcaatACTGTTATTATTGAAGATGTTAAACCTGCTATAGTTCAAGaagttttaagatttatttatgttggaaaagttgataaaattgaaagtatagCTGTTGATCTTTATAAGGCTGCAGATAAATATTTACTAGATGAATTAGAGGATTTGTGTGTGGAATCTTTACATGATACAATATCGATTGAAAATGCGATCGAATATCTGAAACTGGCTAATCATTACAATCTTCATAGTTTGaagcaaaaagttttaaactttATAGGTAAAAACCCAAAAGAGATCGTCGATTCACTAGAATTCAAGAAATTAGGGATTATGAAACCCGACCTCATGCTTAAAGAATTTGATTCTTTAGAGAAACTGATGAAAAATGACGAATTCAGTGACGTTTCTTTAACCGTCGGTGGACAAATTTTTCAGGCGCACAAATGTATATTAGCAAACAAAAGTCCTGTTTTCGCAGCAATGTTTAAACACAacatgaaagaaaaagaaagtaacACTGTTATTATTGAAGACGTTGAGATTGATGTATTCGAGGAAATTTTACGATTCGTTTATATCGGTGAAGTTGAGTGTATTGAAGAGGTAGCGGTTAACCTATTCATTGCCGCAGATAAATATTCGTTAGAGGGCTTAAAAGTTCTGTGcgttgaatatttaaaagatagtaTATCAGTTGATGATGCAGTTAAATATCTTGAACTATCTGATCTCTATCATCTTGATGAAttgcaacaaaaaattttagactTTATGGCTGAACATCCAAAAGAAATCATCGATTTACCAGAATTGAAGCAGGCTGGAAGTATGAAACCTGAACTACTGCTTAAGGTTCTTCGTGCATTGGCACTGGAAATGGAGacgtaa
Protein Sequence: MSESEATNKEVNVISENLMENDKFSDVSLTVGEQIFPAHKCILANRSPVFSAMFEHDMKENKSNTVIIEDVKPAIVQEVLRFIYVGKVDKIESIAVDLYKAADKYLLDELEDLCVESLHDTISIENAIEYLKLANHYNLHSLKQKVLNFIGKNPKEIVDSLEFKKLGIMKPDLMLKEFDSLEKLMKNDEFSDVSLTVGGQIFQAHKCILANKSPVFAAMFKHNMKEKESNTVIIEDVEIDVFEEILRFVYIGEVECIEEVAVNLFIAADKYSLEGLKVLCVEYLKDSISVDDAVKYLELSDLYHLDELQQKILDFMAEHPKEIIDLPELKQAGSMKPELLLKVLRALALEMET*

Sequence clustering based on sequence similarity using MMseqs2